Antigenic breadth - a missing component of an effective vaccine against herpes
Please arrive 5 minutes before the talk begins to gain access to the building
The successful human papillomavirus (HPV) and hepatitis B virus (HBV) subunit vaccines contain single viral proteins that represent 22% and 12%, respectively, of the total antigens encoded by these simple viruses. The herpes simplex virus 2 (HSV-2) genome is 20 and 50 times larger, respectively. Thus, single protein subunit vaccines represent only 1% of HSV-2’s total antigenic breadth. The concept of antigenic breadth offers a unifying explanation for why HSV-2 glycoprotein D subunit vaccines have repeatedly failed in human clinical trials, and why live HSV-2 vaccines that encode 99% of HSV-2’s antigens are more effective in side-by-side tests. We believe that live HSV-2 vaccines represent an unexplored opportunity to stop the genital herpes epidemic.
Date: 13 June 2019, 12:00 (Thursday, 7th week, Trinity 2019)
Venue: Medawar Building, off South Parks Road OX1 3SY
Venue Details: Seminar room, South Parks Road, Oxford, OX1 3SY
Speakers: Speaker to be announced
Organiser: Suki Kenth (University of Oxford)
Organiser contact email address: suki.kenth@ndm.ox.ac.uk
Host: Craig Thompson (Department of Zoology)
Part of: Peter Medawar Building Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Suki Kenth