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Antigenic breadth - a missing component of an effective vaccine against herpes
Please arrive 5 minutes before the talk begins to gain access to the building
The successful human papillomavirus (HPV) and hepatitis B virus (HBV) subunit vaccines contain single viral proteins that represent 22% and 12%, respectively, of the total antigens encoded by these simple viruses. The herpes simplex virus 2 (HSV-2) genome is 20 and 50 times larger, respectively. Thus, single protein subunit vaccines represent only 1% of HSV-2’s total antigenic breadth. The concept of antigenic breadth offers a unifying explanation for why HSV-2 glycoprotein D subunit vaccines have repeatedly failed in human clinical trials, and why live HSV-2 vaccines that encode 99% of HSV-2’s antigens are more effective in side-by-side tests. We believe that live HSV-2 vaccines represent an unexplored opportunity to stop the genital herpes epidemic.
Date:
13 June 2019, 12:00
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Seminar room, South Parks Road, Oxford, OX1 3SY
Speakers:
Speaker to be announced
Organiser:
Suki Kenth (University of Oxford)
Organiser contact email address:
suki.kenth@ndm.ox.ac.uk
Host:
Craig Thompson (Department of Zoology)
Part of:
Peter Medawar Building Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Suki Kenth
