Research in the Elvassore laboratory combines engineering principles with basic biological science to rationally understand the mechanisms governing cell and tissue behavior. We developed reprogramming of human somatic cells to hiPSCs with high efficiency using microfluidics. We showed that nascent states of pluripotency, naïve and primed, have full developmental potential in three-dimension (3D), which enables the morphogenesis of functional organoids. We developed intravital 3D bioprinting technology to control, in space and time, the narrative design of 3D culture systems, acting on the ECM architecture. This intravital technology will also provide an unprecedented tool to control organoid shape in vivo, as well as to quantify mechanical forces at the tissue scale during vertebrate morphogenesis.