The Nuffield Department of Obstetrics & Gynaecology invites you to MitOX 2017 on Friday 1st December, 9:30am – 5:30pm. MitOX is a one day meeting on the role of mitochondria in Health and Disease.
AGENDA
09.00 Registration
SESSION 1 CHAIR: LISA HEATHER
09.30 Welcome by Karl Morten (Oxford)
09.35 Craig Lygate (Oxford) – Cardioprotection by mitochondrial creatine kinase
10.00 Andrew Murray (Cambridge) – Mitochondrial adaptations to high altitude in Himalayan Sherpas
10.25 Tom Nicoll (MRC Harwell) Cardiac arrhythmia resulting from an accumulation of branched chain amin acids in a mouse line with a mutation in Bcat2
10.40 Dunja Aksentijevic (Kings College, London) Causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy
11.05 Coffee
SESSION 2 CHAIR: KARL MORTEN (OXFORD)
11.30 Charles Affourtit (Plymouth) – Unravelling the unusual bioenergetics of pancreatic beta cells
11.55 Patrick Pollard tribute prize for work in Cancer Metabolism. Grahame Hardie (Dundee) – Biguanides, AMPK and cancer therapeutics
12.25 Jo Elson (Newcastle) – A novel approach for investigating mtDNA variation in the context of complex disease
12.40 Cara Tomas (Newcastle) & Jiaboa Xu (Oxford) – Metabolic biomarkers in ME/CFS
13.05 Lunch & Posters
SESSION 3 CHAIR: JO POULTON (OXFORD)
14.30 Joseph Bateman (Kings College) – Mitochondrial retrograde signalling in the nervous system
14.55 Heather Mortiboys (Sheffield) – Mitochondria in neurodegeneration; a realistic therapeutic target?
15.20 Rita Horvath (Newcastle) – Genes and disease mechanisms in mitochondrial translation deficiencies
15.45 Kenneth Pryde (Leicester) – Intra-mitochondrial proteolytic quality control selectively degrades complex I in depolarized mitochondria to constrain ROS production if mitophagy fails.
16.00 Tea/Coffee
SESSION 4 CHAIR: PAUL POTTER (MRC, HARWELL)
16.30 Ivan Gout (UCL) – Protein CoAlation: a novel post-translational modification in redox regulation
16.55 Iain Johnston (Birmingham)-Selfish replication and cell-level selection explain complex tissue specific mtDNA segregation patterns
17.10 Eszter Dombi (Oxford) – Increased mitophagy and mitochondrial DNA (mtDNA) turnover in defects of mtDNA maintenance associated with severe neurodegenerative disease: towards new therapies
17.25 Alex Zhdanov (Cork) New bridge connecting mitochondria and translation: PolGX recruits the mitochondrial p32 protein for ribosome biogenesis
17.40 Drinks & Poster Results and Prize Giving!
19.30 MitOX Dinner
