OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
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Unravelling virus replication-induced organelle remodelling by cellular cryo-electron tomography
Viruses developed various strategies to remodel infected cells to carry out genome replication and generate new progeny. While positive single-stranded RNA viruses hijack membranous organelles to form replication vesicles, many negative single-stranded RNA viruses use liquid organelles as a site of viral genome replication. We apply cellular cryo-electron tomography and correlative light and electron microscopy to study the replication and assembly of SARS-CoV-2 and Ebola viruses. We show that SARS-CoV-2 nsp3-4 are minimal components of the pore spanning double-membrane vesicles. In addition, we revealed Ebola virus nucleocapsid assembly inside membrane-less inclusion bodies using subtomogram averaging
Date:
24 November 2023, 14:00
Venue:
Medical Sciences Teaching Centre, off South Parks Road OX1 3PL
Venue Details:
Lecture Theatre
Speaker:
Dr Petr Chlanda (Schaller Research Group Department of Infectious Diseases - Virology Heidelberg University Hospital)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address:
melissa.wright@path.ox.ac.uk
Host:
Prof Ervin Fodor (Sir William Dunn School of Pathology)
Part of:
Dunn School of Pathology Departmental Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Melissa Wright
