OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
It is generally thought that the adult heart has too little endogenous ability to appreciably restore myocardium that is lost after ischemia or infarction. In contrast, the fetal and early neonatal heart have a very high capacity for cardiomyocyte proliferation and regeneration. Why and how the mammalian heart becomes essentially nonregenerative is one of the enduring mysteries of heart biology. Using genetic approaches, my lab has redefined natural heart regeneration as a variable trait subject to the combined influences of multiple polymorphic genes. With this perspective, a number of longstanding questions now become amenable to experimental evaluation. In this presentation, I will discuss genetic, cellular, and mechanistic insights that have been realized based on this new paradigm, and potential therapeutic strategies that could improve endogenous heart regeneration in all patients regardless of their genetic and cellular composition.
