• Type: Seminar Series
• Series organisers: Liz Rose (University of Oxford, Weatherall Institute of Molecular Medicine) , Anne Farmer (University of Oxford, NDM Experimental Medicine, RDM Investigative Medicine Division) , Linda Roberts (University of Oxford, Weatherall Institute of Molecular Medicine) , Kevin Clark (University of Oxford, Weatherall Institute of Molecular Medicine) , Penny Berry (University of Oxford, Department of Oncology, Weatherall Institute of Molecular Medicine) , Sarah Butler (MRC, Weatherall Institute of Molecular Medic one)
• Organising department: MRC Weatherall Institute of Molecular Medicine

Friday 6 March 2015 (7th Week, Hilary Term)

• 13:00 - Functions, mechanisms and therapeutic potential of chromatin looping
  Dr. Gerd Blobel (The Perelman School of Medicine, University of Pennsylvania, USA)

Thursday 9 April 2015 (-2nd Week, Trinity Term)

• 12:30 - Electron microscopy techniques for biomedical research: from the traditional to the cutting-edge
  Dr Errin Johnson (University of Oxford, Sir William Dunn School of Pathology)

Thursday 30 April 2015 (1st Week, Trinity Term)

• 12:30 - DNA double-strand break repair in immunity and tumour suppression
  Dr Ross Chapman (University of Oxford)

Friday 1 May 2015 (1st Week, Trinity Term)

• 13:00 - Career paths, work/life balance and quality/diversity (Athena Swan - Equality and Diversity Seminar)
  Athena Swan - Equality and Diversity Seminar
  Tudor Fulga (University of Oxford, Weatherall Institute of Molecular Medicine), Irene Roberts (University of Oxford, Weatherall Institute of Molecular Medicine), Professor Marella de Bruijn (University of Oxford, Weatherall Institute of Molecular Medicine)

Wednesday 27 May 2015 (5th Week, Trinity Term)

• 13:15 - Stem Cells, Clones and Cancer
  Dr Connie Eaves (Department of Medical Genetics, University of British Columbia)

Thursday 9 July 2015 (11th Week, Trinity Term)

• 12:30 - Title TBC
  TBA
• 12:30 - Benefits and pitfalls of using micro- and nanotechnology in biomedical research assays
  Professor Martin Dufva (DTU Nanotech)

Wednesday 15 July 2015 (12th Week, Trinity Term)

• 13:00 - Computational Genomics - Analysis and Training (CGAT)
  Dr. David Sims (MRC Functional Genomics Unit, University of Oxford), Dr Andreas Heger (MRC Functional Genomics Unit, University of Oxford)

Thursday 16 July 2015 (12th Week, Trinity Term)

• 14:30 - Forward genetic screens in haploid mammalian cells: looking beyond CRISPR/Cas9
  Dr Josep Forment (University of Cambridge)
• 14:30 - Forward genetic screens in haploid mammalian stem cells: looking beyond CRISPR/Cas9
  Dr Josep Forment (University of Cambridge)

Monday 20 July 2015 (13th Week, Trinity Term)

• 13:00 - Defining stem cell states and regulatory networks using single cell genomics
  Dr Bertie Göttgens (Dept of Haematology, Cambridge Inst for Medical Research)

Tuesday 21 July 2015 (13th Week, Trinity Term)

• 13:00 - Inferring clonal T cell fates from single-cell transcriptomes
  Dr. Mike Stubbington (EMBL - European Bioinformatics Institute, Cambridge)

Monday 27 July 2015 (14th Week, Trinity Term)

• 13:00 - Hematopoietic stem cell function in stress, disease and ageing
  Professor Emmanuelle Passegué (University of California, San Francisco)

Tuesday 4 August 2015 (15th Week, Trinity Term)

• 13:00 - Understanding estrogen receptor activity in breast cancer
  Dr Jason Carroll (Cancer Research UK, University of Cambridge)

Friday 14 August 2015 (16th Week, Trinity Term)

• 13:00 - Lgr5+ stem cells in epithelial homeostasis and cancer
  Professor Nicholas Barker (Institute of Medical Biology, Singapore)

Tuesday 25 August 2015 (18th Week, Trinity Term)

• 13:00 - Molecular investigations into -stem cell- ageing
  Professor Gerald de Haan (University Medical Center Groningen)

Tuesday 1 September 2015 (19th Week, Trinity Term)

• 13:00 - The dynamic epigenome - challenges and opportunities for healthy ageing
  Professor Peter Adams (Beatson Institute for Cancer Research & University of Glasgow)

Wednesday 9 September 2015 (20th Week, Trinity Term)

• 13:30 - Opposing Roles of Obesity on Hematopoietic Stem Cell Transplantation
  Dr William J Murphy (Dept of Internal Medicine-Division of Haematology/Oncology, University of California)

Thursday 10 September 2015 (20th Week, Trinity Term)

• 13:00 - Immunomodulatory Effects of Malaria Protein PfEMP1
  Natalia Sampaio (Walter and Eliza Hall Institute, Melbourne, Australia)

Tuesday 29 September 2015 (-1st Week, Michaelmas Term)

• 11:00 - Systems Immunology – Using an Holistic Approach to Understand the Molecular Mechanisms of Immunity
  Dr Helder Nakaya (Assistant Professor - Dept. of Clinical Analyses & Toxicology, University of Sao Paulo, Brazil and Adjunct Professor, Dept. of Pathology, Emory University School of Medicine)

Tuesday 20 October 2015 (2nd Week, Michaelmas Term)

• 11:00 - Exploiting replication stress to target histone H3K36me3-deficient cancers
  Dr Tim Humphrey (University of Oxford, Old Road Campus Research Building)

Thursday 5 November 2015 (4th Week, Michaelmas Term)

• 13:00 - Genetic and epigenetic roots of an autism spectrum disorder
  Professor Adrian Bird (Buchanan Chair of Genetics, University of Edinburgh)

Thursday 12 November 2015 (5th Week, Michaelmas Term)

• 12:00 - OIG Post Doc Day
  The event is directed at Post-docs working in immunology at Oxford, but everyone from the University is welcome. This time we have a very special set of guest speakers talking about: • Grant writing from a medical director’s perspective - Professor Alan Silman (Arthritis Research UK’s medical director for 8 years) • Career options for PhD holders: a patent attorney and a medical/scientific writer will be sharing their experiences • Techniques: genomics, CRISPR technology and imaging Registration is free and open to all: http://oig-post-doc-day.eventbrite.co.uk
  TBA

Tuesday 8 December 2015 (9th Week, Michaelmas Term)

• 11:00 - The identification and characterisastion of disease genes in craniosynostosis
  Viva Seminar
  Aimee Fenwick (Weatherall Institute of Molecular Medciine)

Monday 14 December 2015 (10th Week, Michaelmas Term)

• 13:00 - Stimulating fetal haemoglobin expression for sickle cell disease
  Dr Mitch Weiss (St Jude Children's Research Hospital, Memphis, USA)

Tuesday 15 December 2015 (10th Week, Michaelmas Term)

• 11:00 - Analysis of transcription factor binding at cis-regulatory elements during blood development and differentiation
  Viva Seminar
  Maria Suciu (MRC Molecular Haematology Unit, WIMM)

Friday 18 December 2015 (10th Week, Michaelmas Term)

• 10:30 - The Use of Dendritic Cells in Cancer Immunotherapy
  Professor Derek Hart (ANZAC Research Institute, Dendritic Cell Biology and Therapeutics Group, Concord, Australia)

Monday 21 December 2015 (11th Week, Michaelmas Term)

• 13:00 - Understanding regulation of zeta-globin transcription as the first step towards embryonic globin induction in pateints with severe alpha-thalassaemia
  Viva Seminar
  Duantida Songdej (MRC Molecular Haematology Unit, WIMM)

Wednesday 20 January 2016 (1st Week, Hilary Term)

• 12:30 - Identification of critical effectors of C/EBPalpha mutant AML - Novel molecular insights and targeting strategies
  Dr. Florian Grebien (CeMM Research Center for Molecular Medicine, Vienna, Austria)

Thursday 21 January 2016 (1st Week, Hilary Term)

• 11:30 - Unraveling the molecular and cellular mechanisms of fetal B cell lymphopoiesis to help understand childhood leukaemia
  Viva Seminar
  Joanna Green (Molecular Haematology Unit, WIMM)
• 12:30 - Protein ADP-ribosylation in regulation of genome stability
  Dr Ivan Ahel (Sir William Dunn School of Pathology, University of Oxford)

Friday 22 January 2016 (1st Week, Hilary Term)

• 10:15 - Unravelling haematopoietic stem cell dysfunction in isolated Del(5q) myelodysplastic syndromes
  Viva Seminar
  Laura Stenson (Molecular Haematology Unit, WIMM)

Thursday 28 January 2016 (2nd Week, Hilary Term)

• 13:30 - Genome-wide analyses reveal new insights into MLL fusion protein recruitment mechanisms
  Viva Seminar
  Jon Kerry (Molecular Haematology Unit, WIMM)

Friday 29 January 2016 (2nd Week, Hilary Term)

• 13:00 - Epigenetic dysfunction and its targeting in haematological malignancies
  Dr Brian Huntly (Cambridge Stem Cell Institute)

Friday 5 February 2016 (3rd Week, Hilary Term)

• 13:00 - How to be open about the use of animals in scientific research
  Carmel Turner (Chief Press Officer, Medical Research Council)

Tuesday 9 February 2016 (4th Week, Hilary Term)

• 13:00 - Lineage bias and restriction of haematopoietic stem and progenitor cells
  Viva Seminar
  Joana de Teixeira Carrelha (Molecular Haematology Unit, WIMM)

Monday 15 February 2016 (5th Week, Hilary Term)

• 14:30 - Investigating the regulatory consequences of genetics and age on primary immune cell gene expression, DNA methylation and function
  Dr Ben Fairfax (Oxford Cancer Centre, Churchill Hospital)

Thursday 18 February 2016 (5th Week, Hilary Term)

• 13:15 - The large scale features of chromatin 3D organisation
  Professor Mario Nicodemi (Universita' di Napoli "Federico II", Italy)

Friday 19 February 2016 (5th Week, Hilary Term)

• 11:30 - Statistical tools based on latent variable models to understand heterogeneity in single-cell gene expression data
  Dr. Florian Buettner (EMBL, European Bioinformatics Institute)

Wednesday 24 February 2016 (6th Week, Hilary Term)

• 15:00 - Single-Cell Systems Biology: The Now and The Next
  Dave Ruff (Visiting Senior Research Fellow & Principal Scientist at Fluidigm)

Thursday 25 February 2016 (6th Week, Hilary Term)

• 13:15 - Genetics and pathophysiology of coronal craniosynostosis revealed by Next-Generation DNA sequencing
  Viva Seminar
  Vikram Pramod Sharma (Weatherall Institute of Molecular Medicine)

Friday 26 February 2016 (6th Week, Hilary Term)

• 13:00 - The function and execution of RTEL1 activities at vertebrate telomeres
  Dr Simon Boulton (The Francis Crick Institute, London)

Friday 4 March 2016 (7th Week, Hilary Term)

• 13:00 - "Career paths, work/life balance and equality/diversity"
  Status: This talk is in preparation - details may change
  Professor Angela Vincent ((Neurosciences/WIMM), University of Oxford), Professor Katja Simon ((Kennedy Institute) University of Oxford), Professor Paresh Vyas ((MHU/WIMM))

Friday 11 March 2016 (8th Week, Hilary Term)

• 13:00 - Single-cell analysis of haematopoietic stem cell identity and behaviour
  Dr David Knapp (Terry Fox Laboratory, Vancouver)

Monday 14 March 2016 (9th Week, Hilary Term)

• 14:00 - Maintenance of spermatogenic stem cell pool by mitogen competition
  Professor Shosei Yoshida (Division of Germ Cell Biology, Okazaki, Japan)

Thursday 24 March 2016 (10th Week, Hilary Term)

• 12:30 - How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?
  Dr Puck Knipscheer (Hubrecht Institute, Utrecht, Netherlands)

Tuesday 5 April 2016 (-2nd Week, Trinity Term)

• 13:00 - DNA repair, NAD+ and mitophagy in neurodegeneration and ageing
  Dr Evandro Fang (National Institutes on Aging, Bethesda, MD, USA)

Wednesday 13 April 2016 (-1st Week, Trinity Term)

• 16:00 - Evolutionary tradeoffs and the geometry of gene expression space
  Professor Uri Alon (Weizmann Institute of Science)
• 17:15 - Love and fear in the lab - a guitar talk on the importance of emotions in science
  Professor Uri Alon (Weizmann Institute of Science)

Monday 25 April 2016 (1st Week, Trinity Term)

• 14:30 - Restriction of HIV-1 and HIV-2 infection in myeloid and lymphoid cells
  Lise Chauveau (Pasteur Institute)

Friday 29 April 2016 (1st Week, Trinity Term)

• 11:30 - DNA interstrand cross-link and mismatch repair
  Dr Jean Gautier (University of Columbia/Institut Curie)
• 13:00 - Noncoding RNA regulation of myeloid transcription factors, DNA methylation and leukaemia
  Daniel G Tenen (Cancer Science Institute, National University of Singapore)

Wednesday 4 May 2016 (2nd Week, Trinity Term)

• 13:00 - Crosstalk between RNA processing and chromatin remodelling as a modulator of genome integrity
  Dr Andres Aguilera (Department of Genetics, University of Seville, Spain)

Friday 27 May 2016 (5th Week, Trinity Term)

• 13:00 - HSC developmental diversity
  Professor Elaine Dzierzak (MRC Centre for Inflammation Research, University of Edinburgh)

Wednesday 15 June 2016 (8th Week, Trinity Term)

• 15:15 - A systems biology approach to identifying drug targets and predicting therapeutic outcomes in myelodysplasia and acute myeloid leukaemia
  Ass. Professor John Pimanda (Prince of Wales Clinical School, UNSW, Australia)

Wednesday 29 June 2016 (10th Week, Trinity Term)

• 13:30 - Development of the AGM region in the chick embryo
  Dr Tom Schultheiss (Dept of Genetics & Developmental Biology, Technion-Israel Inst of Technology, Haifa)

Friday 8 July 2016 (11th Week, Trinity Term)

• 13:00 - Management of Ph+ AML Current and Future
  Professor Oliver Ottman (Division of Cancer & Genetics, School of Medicine, Cardiff University)

Friday 9 September 2016 (20th Week, Trinity Term)

• 13:00 - Bioinformatics Tools and Pitfalls with single-cell Data
  Davis McCarthy (EMBL-EBI)

Monday 12 September 2016 (21st Week, Trinity Term)

• 13:00 - Characterising transcriptional heterogeneities during cellular differentiation
  Professor Fabian Theis (Institute of Computational Biology, Helmholtz Zentrum Muenchen, Germany)

Thursday 29 September 2016 (-1st Week, Michaelmas Term)

• 12:30 - Temporal regulation of genome replication
  Professor Conrad Nieduszynski (University of Oxford, Sir William Dunn School of Pathology)

Friday 14 October 2016 (1st Week, Michaelmas Term)

• 13:00 - Nuclear inositide pathways: Phospholipase C signalling and initiation of cancer
  Professor Lucio Cocco (Dept of Biomedical Sciences, University of Bologna, Italy)

Thursday 20 October 2016 (2nd Week, Michaelmas Term)

• 12:30 - Decoding the human antiviral gene expression code
  Dr Marios Agelopoulos (Biomedical Research Foundation, Athens)

Tuesday 25 October 2016 (3rd Week, Michaelmas Term)

• 12:00 - Molecular mechanisms regulating human pluripotent stem cell differentiation
  Dr Siim Pauklin (Wellcome Trust-MRC Stem Cell Institute, Cambridge)

Tuesday 8 November 2016 (5th Week, Michaelmas Term)

• 16:40 - Unlocking the diagnostic potential of circulating DNA
  Professor Dennis Lo (The Chinese University of Hong Kong )

Friday 11 November 2016 (5th Week, Michaelmas Term)

• 13:00 - Career paths, work/life balance and equaity/diversity
  Athena Swan - Equality and Diversity Seminar
  Dr Rui Monteiro, Dr. Lynn Quek & Professor Catherine Porcher (MRC WIMM, University of Oxford)

Thursday 1 December 2016 (8th Week, Michaelmas Term)

• 11:00 - New approaches to the investigation of the interactions between enhancers and promoters during haemopoiesis
  VIVA SEMINAR
  Dr James Davies (Prof Doug Higgs' Group, Molecular Haematology Unit, WIMM)

Friday 2 December 2016 (8th Week, Michaelmas Term)

• 13:00 - Long-distance interactions in gene expression control: function and regulation by the 3D genome's architecture
  Dr Francois Spitz (Dept of Developmental Biology & Stem Cells, Institute Pasteur, Paris, France)

Thursday 8 December 2016 (9th Week, Michaelmas Term)

• 14:00 - Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection
  Professor Petr Cejka (Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland)

Tuesday 20 December 2016 (11th Week, Michaelmas Term)

• 11:00 - Lineage commitment and chromatin dynamics
  Professor Frank Grosveld (Erasmus Medical Center, The Netherlands)
• 13:00 - The role of elements binding CTCF and Cohesin in directing tissue-specific enhancer activity
  VIVA SEMINAR
  Lars Hanssen (Prof Doug Higgs' Group, Molecular Haematology Unit, WIMM)

Thursday 12 January 2017 (0th Week, Hilary Term)

• 11:00 - Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium
  VIVA SEMINAR
  Christina Rode (Prof Marella de Bruijn's Group, MRC Molecular Haematology Unit, WIMM)

Wednesday 25 January 2017 (2nd Week, Hilary Term)

• 13:00 - Genetic and epigenetic determinants of blood cells and links to human disease
  Professor Nicole Soranzo (The Wellcome Trust Sanger Institute, Hinxton, Cambridge)

Thursday 26 January 2017 (2nd Week, Hilary Term)

• 14:00 - The role of homologous recombination proteins in vertebrate DNA replication
  Dr Vincenzo Costanzo (DNA metabolism laboratory, IFOM, Milan)

Thursday 2 March 2017 (7th Week, Hilary Term)

• 13:00 - Proteomic modeling of erythropoiesis
  Dr Marjorie Brand (Sprott Center for Stem Cell Research, University of Ottawa)

Tuesday 14 March 2017 (9th Week, Hilary Term)

• 11:00 - TBA
  TBA

Wednesday 22 March 2017 (10th Week, Hilary Term)

• 13:00 - LMO2 protein complexes driving haematopoietic cell fate and leukaemogenesis
  Dr Trang Hoang (Institute for Research in Immunology and Cancer (IRIC), Montreal, Canada)

Thursday 23 March 2017 (10th Week, Hilary Term)

• 11:15 - "A common functional role of SCL and LYL1 in red cell and platelet production”
  Prof David Curtis (Monash University, Australia)

Wednesday 26 April 2017 (1st Week, Trinity Term)

• 13:00 - Assessing the effect of single nucleotide variants on the expression of key human genes
  Professor Merlin Crossley (University of New South Wales, Sydney, Australia)

Thursday 27 April 2017 (1st Week, Trinity Term)

• 12:30 - Genomic instability and disease: opportunities for clinical translation
  Dr Gabriel Balmus (Gurdon Institute/Sanger Centre)

Friday 28 April 2017 (1st Week, Trinity Term)

• 11:00 - CHD7 in CHARGE: the implications of neural crest specific regulation of chromatin remodeller CHD7 in CHARGE syndrome
  VIVA SEMINAR
  Günes Taylor (MRC WIMM, University of Oxford)

Monday 8 May 2017 (3rd Week, Trinity Term)

• 15:30 - Pluripotent stem cells to model human hemato-lymphoid development
  Professor Dan Kaufman (Dept of Medicine, University of California, San Diego, USA)

Friday 26 May 2017 (5th Week, Trinity Term)

• 13:00 - "The role of histone demethylase LSD1/KDM1A in zebrafish haematopoiesis"
  Makoto Kobayashi (University of Tsukuba)

Thursday 22 June 2017 (9th Week, Trinity Term)

• 13:00 - Glioblastomas: A Tale of Stem Cells, Dedifferentiation and Transdifferentiation
  Inder Verma (The Salk Institute)

Wednesday 12 July 2017 (12th Week, Trinity Term)

• 10:30 - A new approach for single cell whole genome amplification
  TBA

Friday 14 July 2017 (12th Week, Trinity Term)

• 13:00 - Characterizing the molecular identity of dormant hematopoietic stem cells
  Dr Florian Buettner (EMBL)

Wednesday 26 July 2017 (14th Week, Trinity Term)

• 15:30 - A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR
  Dr Joseph Kwong (Chinese University of Hong Kong)

Wednesday 30 August 2017 (19th Week, Trinity Term)

• 12:30 - Identification of a targetable EGFR-associated tumor-initiating program in breast cancer using single cell genomics
  Please note that if you require further details, the contact is Sam Oats, not Penny Berry (aharris.lab@imm.ox.ac.uk).
  Prof Jiannis Ragoussis (McGill University and Génome Québec Innovation Centre)

Tuesday 19 September 2017 (-2nd Week, Michaelmas Term)

• 12:00 - The biology of ELTD1/ADGRL4: a novel regulator of tumour angiogenesis
  VIVA SEMINAR
  David Favara (Department of Molecular Oncology, MRC WIMM)

Friday 22 September 2017 (-2nd Week, Michaelmas Term)

• 13:00 - “Insights into Hematopoiesis and Aging from the Rhesus Macaque Model”
  Cynthia Dunbar (National Institutes of Health, Bethesda)

Monday 2 October 2017 (0th Week, Michaelmas Term)

• 16:00 - "Identifying the key function of MeCP2 via genetic manipulation in mice"
  TBA

Thursday 19 October 2017 (2nd Week, Michaelmas Term)

• 12:30 - IGF2BP1 promotes the immune escape in advanced stage ovarian cancer
  Dr Nadine Bley (University of Halle)

Friday 20 October 2017 (2nd Week, Michaelmas Term)

• 13:00 - “CRISPR-Cas Gene Editing: Defining Genome-wide Activity for Therapeutics”
  Shengdar Tsai (St. Jude Children’s Research Hospital)

Friday 27 October 2017 (3rd Week, Michaelmas Term)

• 13:00 - How LAB282 accelerates Oxford drug discovery
  Thomas Hank (Evotec)

Thursday 2 November 2017 (4th Week, Michaelmas Term)

• 10:00 - “Definition and Analysis of an MLL-AF4 Gene Regulatory Network”
  Ross Thorne (MRC Molecular Haematology Unit, University of Oxford)

Thursday 30 November 2017 (8th Week, Michaelmas Term)

• 12:30 - “Molecular Regulation and Function of GATA2 in the Programming of Haemogenic Endothelium”
  VIVA SEMINAR
  Tomasz Dobrzycki (University of Oxford)

Tuesday 5 December 2017 (9th Week, Michaelmas Term)

• 12:00 - Biotagging, a genetically encoded toolkit in the zebrafish, reveals novel non-coding RNA players during neural crest and myocardium development
  Vanessa Mae Ren CHONG (University of Oxford)

Thursday 14 December 2017 (10th Week, Michaelmas Term)

• 11:30 - Identification of Novel Runx1 Targets Involve in HSC Development
  Florian Bonkhofer (University of Oxford)

Wednesday 17 January 2018 (1st Week, Hilary Term)

• 11:00 - "Collaboration of Ezh2 and Runx1 Inactivating Mutations in Malignant Haematopoiesis”
  VIVA SEMINAR
  Chris Booth (MRC Weatherall Institute Molecular Medicine)
• 12:00 - "The role and impact of Del(5q) and TP53 mutations on haematopoietic stem and progenitor cells during progression of Myelodysplastic Syndromes to Acute Myeloid Leukaemia”
  VIVA SEMINAR
  Helen Doolittle (MRC Weatherall Institute Molecular Medicine)

Friday 26 January 2018 (2nd Week, Hilary Term)

• 11:30 - Next generation sequencing to identify new genetic causes of familial craniosynostosis
  Akiko Hashimoto (University of Oxford)

Friday 2 February 2018 (3rd Week, Hilary Term)

• 13:00 - "Is hard work enough to be successful?" A perspective from experiences in Government, Business and Health Care
  Millie Banerjee (NHS Blood Transfusion)

Thursday 22 February 2018 (6th Week, Hilary Term)

• 13:00 - 'The role of DOT1L in MLL-AF4 leukaemia’
  Viva Seminar
  Laura Godfrey (University of Oxford)

Thursday 8 March 2018 (8th Week, Hilary Term)

• 12:00 - “Regulating Pol II transcription for genome stability”
  Dr Taka Nojima (Sir William Dunn School of Pathology, University of Oxford)

Tuesday 13 March 2018 (9th Week, Hilary Term)

• 09:15 - Analysis of a gain-of-function mutation that produces a new transcriptional unit in the α-globin locus
  Viva Seminar
  Yavor Bozhilov (MRC Molecular Haematology Unit, MRC WIMM)

Tuesday 27 March 2018 (11th Week, Hilary Term)

• 13:00 - Single Cell Data Analysis Using Partek Flow
  Ivan Lukic (Partek Inc), Alison Hargreaves (Partek Inc)

Friday 13 April 2018 (-1st Week, Trinity Term)

• 12:00 - The Nature of Nurture
  Professor Augustine Kong (Big Data Institute, University of Oxford)

Thursday 19 April 2018 (0th Week, Trinity Term)

• 11:15 - Redirecting the cellular information flow with programmable dCas9-based chimeric receptors
  Viva Seminar
  Toni Baeumler (University of Oxford)
• 13:00 - “Immortal Hematopoietic Stem Cells and Their Epigenetic Regulation”
  Margaret (“Peggy”) Goodell (Baylor College of Medicine, in Houston, Texas)

Monday 23 April 2018 (1st Week, Trinity Term)

• 09:00 - Oxford Single Cell Symposium 2018
  Speakers so far confirmed are: Wolf Reik (Babraham Institute); Ido Amit (Weizmann Institute of Science)
  Various Speakers

Wednesday 25 April 2018 (1st Week, Trinity Term)

• 13:00 - Elucidating the molecular mechanisms underlying the endothelial to hematopoietic transition
  Viva Seminar
  Lucas Greder (University of Oxford)

Friday 18 May 2018 (4th Week, Trinity Term)

• 13:00 - "Career paths, work/life balance and equality/diversity"
  Anne Bridgeman (University of Oxford), Mira Kassouf (University of Oxford), Tiago Luis (University of Oxford)

Monday 2 July 2018 (11th Week, Trinity Term)

• 11:00 - Genome Editing of Stem Cells: Moving Towards the Clinic
  Dr. Matthew Porteus (Stanford University, School of Medicine)
• 15:00 - Migraine – a real headache for science patients and society
  Dr. Danny Bar Zohar (Novartis Pharma AG)

Wednesday 5 September 2018 (20th Week, Trinity Term)

• 13:00 - “Disentangling the interconnected roles between DNA repair, NAD+, and mitophagy in ageing and neurodegeneration”
  Dr. Evandro F. Fang (University of Oslo )

Monday 10 September 2018 (21st Week, Trinity Term)

• 11:30 - “Elevation of D133p53b isoform expression - a mechanism for wild type p53 to cause cancer”
  Professor Antony Braithwaite (School of Medicine, University of Otago)
• 13:45 - "The three-dimensional regulatory landscapes of the globin genes”
  TBA

Monday 15 October 2018 (2nd Week, Michaelmas Term)

• 13:00 - THIS SEMINAR HAS NOW BEEN CANCELLED - Mechanisms controlling homeostasis in mammalian epidermis
  THIS SEMINAR HAS NOW BEEN CANCELLED 2018 Craig Jordan Lecture
  Professor Fiona Watt (Centre for Stem Cells & Regenerative Medicine, King's College London)

Friday 9 November 2018 (5th Week, Michaelmas Term)

• 13:00 - CANCELLED - Inspiring the young generation of scientists - Equality and Diversity Seminar
  Professor Marianne Bronner (California Institute of Technology)

Wednesday 21 November 2018 (7th Week, Michaelmas Term)

• 09:15 - “How does leukaemia disrupt hematopoiesis?” Viva Seminar
  Viva Seminar
  TBA

Thursday 6 December 2018 (9th Week, Michaelmas Term)

• 12:00 - VIVA -Modelling Arterial and Haemogenic Endothelium Development from Mouse and Human Pluripotent Stem Cells
  JUAN RUIZ VILLALOBOS (University of Oxford)

Monday 10 December 2018 (10th Week, Michaelmas Term)

• 11:30 - VIVA - “Fine tuning gene expression levels in mammalian cells with engineered microRNA target sites”
  Yale Michaels (University of Oxford)
• 14:30 - VIVA - “Cancer cell killing using engineered antibody fragments”
  Jennifer Chambers (University of Oxford)

Thursday 13 December 2018 (10th Week, Michaelmas Term)

• 09:30 - VIVA "Characterising early human lympho-myeloid harmatopoetic progenitors and their relationship with acute myeloid leukaemia stem cells"
  Zahra Aboukhalil (University of Oxford)
• 12:00 - VIVA - "Acquired Alpha Thalassaemia in Myelodysplastic Syndrome"
  Pak Leng Cheong (University of Oxford)
• 13:30 - VIVA - ‘The molecular and cellular basis for oncogene collaboration in acute myeloid leukaemia’
  Cristina Di Genua (University of Oxford)

Friday 14 December 2018 (10th Week, Michaelmas Term)

• 13:00 - CAREER SEMINAR “A story of development and differentiation – from red blood cells to career moves”
  Dr Maria Suciu (Genomics plc)

Tuesday 18 December 2018 (11th Week, Michaelmas Term)

• 13:00 - VIVA - "Evaluating selfish spermatogonial selection and its role in human disease"
  Hannah Ralph (University of Oxford)

Tuesday 8 January 2019 (0th Week, Hilary Term)

• 13:00 - VIVA - "Role of the chromatin remodeler ATRX in the regulation of gene expression"
  Julia Truch (University of Oxford)

Friday 15 February 2019 (5th Week, Hilary Term)

• 13:00 - "Living with uncertainty: The joy of being wrong”
  TBA

Thursday 7 March 2019 (8th Week, Hilary Term)

• 16:00 - A Human Liver Cell Atlas: Revealing Adult Liver Progenitors by Single-Cell RNA-sequencing
  If you would like to speak to Dominic before his talk contact edward.morrissey@imm.ox.ac.uk
  TBA

Friday 15 March 2019 (9th Week, Hilary Term)

• 13:00 - TBA - Equality and Diversity seminar
  Jo Pisani (PwC Strategy)

Wednesday 20 March 2019 (10th Week, Hilary Term)

• 13:30 - “How to Write a Histone Code”
  Professor David Shechter (Albert Einstein College of Medicine)

Thursday 28 March 2019 (11th Week, Hilary Term)

• 16:00 - Organisation and turnover of developmental regulatory elements in Metazoan genomes
  If you would like to speak to Prof. Lenhard, please contact supat.thongjuea@imm.ox.ac.uk
  Prof. Boris Lenhard (Imperial College London)

Friday 12 April 2019 (-2nd Week, Trinity Term)

• 13:00 - "Challenges to understanding the lateral organization and mobility of plasma membrane components"
  Prof. Ken Jacobson (UNC Chapel Hill )

Tuesday 14 May 2019 (3rd Week, Trinity Term)

• 14:00 - "Editing the human genome with programmable and tunable zinc finger nucleases"
  Adrian Woolfson (Sangamo), Ed Rebar (Sangamo)

Monday 20 May 2019 (4th Week, Trinity Term)

• 13:00 - "Pooled CRISPR/Cas9 genetic screening: methods, applications and an unexpected finding"
  If you would like to speak to Bernhard, please contact Philip philip.hublitz@ndcls.ox.ac.uk
  Dr Bernhard Schmierer (Karolinska Institute )

Thursday 30 May 2019 (5th Week, Trinity Term)

• 14:00 - cGAS STING signalling in cancer
  Dr Eileen Parkes (Health Sciences Bldg, Queens University Belfast)

Monday 29 July 2019 (14th Week, Trinity Term)

• 13:00 - “Stem cells for studying dendritic cell development and leukaemia”
  TBA

Monday 12 August 2019 (16th Week, Trinity Term)

• 12:30 - "Mechanism of improved human hematopoietic stem cell engraftment in NSGW41 mice"
  Dr Susann Rahmig (Leibniz Institute on Aging - Fritz Lipmann Institute)

Thursday 15 August 2019 (16th Week, Trinity Term)

• 11:00 - "The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signalling"
  Antoine David (INSERM Unité 976, Université Pari)

Friday 27 September 2019 (-2nd Week, Michaelmas Term)

• 13:00 - “Ribosomopathies: Biology, Diagnosis and New Treatment Directions”
  Anu Narla (Lucile Packard Children's Hospital Stanford, CA,)

Thursday 31 October 2019 (3rd Week, Michaelmas Term)

• 11:30 - VIVA - How do Gata1 and cohesin gene mutations contribute to the development of myeloid leukaemia?
  Catherine Garnett (University of Oxford)

Monday 11 November 2019 (5th Week, Michaelmas Term)

• 11:00 - VIVA - “Functional Dissection of a Single Enhancer at the Mouse a-Globin Locus”
  Helena Francis (University of Oxford)

Monday 18 November 2019 (6th Week, Michaelmas Term)

• 16:00 - “Clonal hematopoiesis in human aging and disease”.
  Siddhartha Jaiswal (Stanford University, USA)

Thursday 21 November 2019 (6th Week, Michaelmas Term)

• 13:30 - The regulation of zeta-globin
  VIVA SEMINAR
  Dr. Andrew King (MRC Weatherall Institute of Molecular Medicine)

Friday 22 November 2019 (6th Week, Michaelmas Term)

• 13:00 - “Ontogeny of hematopoiesis: making blood before a blood stem cell”
  James Palis, M.D (University of Rochester Medical Center)

Thursday 28 November 2019 (7th Week, Michaelmas Term)

• 14:00 - “Long-term ex vivo expansion of functional hematopoietic stem cells”
  TBA

Wednesday 4 December 2019 (8th Week, Michaelmas Term)

• 13:00 - Genetic screening to investigate treatment resistance in MLL-rearranged leukaemia
  VIVA SEMINAR
  Maximilian Jamilly (University of Oxford)

Monday 16 December 2019 (10th Week, Michaelmas Term)

• 11:00 - Investigating the mechanisms and elements responsible for regulatory domain formation during gene regulation
  VIVA SEMINAR
  Caroline Harrold (University of Oxford)
• 13:30 - Human fetal B-lymphopoiesis and acute lymphoblastic leukaemia: the impact of trisomy 21
  VIVA SEMINAR
  Ms Sorcha O'Byrne (University of Oxford)

Wednesday 8 January 2020 (-1st Week, Hilary Term)

• 09:45 - Elucidating the cis-regulatory logic of Runx1 during developmental haematopoiesis
  VIVA SEMINAR
  Dominic Owens (University of Oxford)

Monday 3 February 2020 (3rd Week, Hilary Term)

• 11:30 - Genetic modelling of human erythroleukemia
  Alexandre Fagnan (Institut Gustave Roussy)

Friday 14 February 2020 (4th Week, Hilary Term)

• 13:00 - 9 useful ideas for women (and men) who work
  Diversity and Inclusion Seminar
  Kathryn Bishop (Said Business School)

Monday 17 February 2020 (5th Week, Hilary Term)

• 13:00 - Method development for the generation and selection of precise genomic edits in human cells
  Viva Seminar
  Alice Lightowlers (University of Oxford)

Thursday 20 February 2020 (5th Week, Hilary Term)

• 11:00 - G-quadruplex structures in neurobiology and neuropharmacology
  Dr Norifumi Shioda (Dept of Genomic Neurology, Kumamoto University, Japan)

Monday 30 March 2020 (11th Week, Hilary Term)

• 10:00 - “The HUSH epigenetic repressor complex – defending the genome from retroelement attack”
  Status: This talk has been cancelled
  Profressor Paul Lehner (Cambridge Institute for Medical Research)
• 13:00 - Genetic and molecular basis of myeloid neoplasms at single cell resolution
  VIVA SEMINAR
  Alba Rodriguez-Meira (University of Oxford)

Monday 6 September 2021 (20th Week, Trinity Term)

• 12:00 - Optimising CRISPR for targeting of primary haematopoietic stem cells
  Viva Seminar
  Lucy Field

Wednesday 8 September 2021 (20th Week, Trinity Term)

• 11:30 - Applying single cell-based technologies to the characterisation of human haematopoietic stem cell heterogeneity
  VIVA SEMINAR
  Merve Aksoz (University of Oxford)

Thursday 30 September 2021 (-1st Week, Michaelmas Term)

• 13:00 - The dynamics of somatic mosaicism in hematopoiesis
  Prof Thomas Höfer (DKFZ)

Monday 21 November 2022 (7th Week, Michaelmas Term)

• 11:00 - Immune marrow failure: New approaches in the research laboratory and clinic
  Neal Young (NIH)

Thursday 15 December 2022 (10th Week, Michaelmas Term)

• 12:30 - Mitochondrial metabolism in self-renewing hematopoietic stem cells.
  Prof Toshio Suda (CSI Singapore)

Monday 19 December 2022 (11th Week, Michaelmas Term)

• 11:00 - The role of chromatin regulators in subverting haematopoietic stem and progenitor function
  Status: This talk has been cancelled
  Prof Brian Huntly (University of Cambridge)

Thursday 2 February 2023 (3rd Week, Hilary Term)

• 12:30 - Mitochondrial metabolism in self-renewing hematopoietic stem cells
  Prof Toshio Suda (Cancer Science Institute of Singapore)

Thursday 9 February 2023 (4th Week, Hilary Term)

• 12:30 - Probing genome, nucleosome and transcriptome dynamics with acute protein depletion
  Elzo de Wit (Netherlands Cancer Institute)

Thursday 22 June 2023 (9th Week, Trinity Term)

• 11:00 - Lister Prize Presentation James Davies - Using base pair mapping of chromatin structure to interrogate genome function
  Dr James Davies (MRC Weatherall Institute of Molecular Medicine)

Friday 22 September 2023 (-2nd Week, Michaelmas Term)

• 15:30 - TBC
  Dr Jef Boeke (NYU Langone Medical Center)

Tuesday 19 December 2023 (11th Week, Michaelmas Term)

• 13:00 - "Synergistic insulation of regulatory domains by developmental genes and clusters of CTCF sites ".
  Álvaro Rada-Iglesias (Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), CSIC/University of Cantabria)

Monday 29 April 2024 (2nd Week, Trinity Term)

• 12:30 - Prostaglandin E2 hampers tumour-infiltrating lymphocyte expansion by collapsing interleukin-2 signalling and mitochondrial function
  Dr Matteo Morotti (CHUV, Lausanne)