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BEGIN:VEVENT
SUMMARY:Reaching the target for neglected tropical diseases - Dr Deirdre H
 ollingsworth (University of Warwick)
DTSTART;VALUE=DATE-TIME:20170403T120000
DTEND;VALUE=DATE-TIME:20170403T130000
UID:https://talks.ox.ac.uk/talks/id/3ab63c6e-6bcc-420e-ac39-cde6479319be/
DESCRIPTION:Several neglected tropical diseases are targeted for ‘elimin
 ation as a public health problem’ by 2020\, reducing the burden amongst 
 the poorest populations in the world\, the ‘bottom billion’. As 2020 a
 pproaches there is a drive to use new tools and adapt existing strategies 
 to achieve the goals in as many countries as possible. Alongside these eff
 orts there also needs to be an assessment of whether true elimination is f
 easible and\, if not\, what strategies could be used to ‘hold the line
 ’.   Using the example of lymphatic filariasis\, a mosquito-borne helmin
 th which can cause debilitating symptoms such as elephantiasis\, we will d
 iscuss the use of multiple models and\, more recently\, geo-spatial data\,
  to inform control strategies at the international policy level through to
  endemic country level.\nSpeakers:\nDr Deirdre Hollingsworth (University o
 f Warwick)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar room B )\, Head
 ington OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/3ab63c6e-6bcc-420e-ac39-cde6479319be/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Reaching the target for neglected tropical diseases - Dr 
 Deirdre Hollingsworth (University of Warwick)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Lexogen seminar highlighting the benefits of QuantSeq 3' mRNA-Seq 
 library prepartion for Next Generation Sequencing - Professor Jernej Ule (
 Professor of Molecular Neuroscience\, The Francis Crick Institute\, Depart
 ment of Molecular Neuroscience\, UCL Institute of Neurology\, London)\, As
 sociate Professor André Furger (Chromosomal and RNA Biology\, Department 
 of Biochemistry University of Oxford)
DTSTART;VALUE=DATE-TIME:20170405T130000
DTEND;VALUE=DATE-TIME:20170405T140000
UID:https://talks.ox.ac.uk/talks/id/a1ce3470-2f11-4c4d-b531-39e2f7876336/
DESCRIPTION:Lexogen in association with the Oxford Genomics Centre invites
  you to a lunchtime seminar highlighting the benefits of QuantSeq 3' mRNA-
 Seq library preparation for Next Generation Sequencing.\n\nSpeakers:\n\nPr
 ofessor Jernej Ule\n‘High-resolution RNA maps demonstrate common princip
 les of splicing and polyadenylation regulation by TDP-43’.\n\nAssociate 
 Professor André Furger\n‘The role of alternative cleavage and polyadeny
 lation in gene regulation’.\nSpeakers:\nProfessor Jernej Ule (Professor 
 of Molecular Neuroscience\, The Francis Crick Institute\, Department of Mo
 lecular Neuroscience\, UCL Institute of Neurology\, London)\, Associate Pr
 ofessor André Furger (Chromosomal and RNA Biology\, Department of Biochem
 istry University of Oxford)
LOCATION:Wellcome Trust Centre for Human Genetics (Roosevelt Drive Oxford\
 , OX3 7BN\, Seminar room A & B)\, Headington OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/a1ce3470-2f11-4c4d-b531-39e2f7876336/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Lexogen seminar highlighting the benefits of QuantSeq 3' 
 mRNA-Seq library prepartion for Next Generation Sequencing - Professor Jer
 nej Ule (Professor of Molecular Neuroscience\, The Francis Crick Institute
 \, Department of Molecular Neuroscience\, UCL Institute of Neurology\, Lon
 don)\, Associate Professor André Furger (Chromosomal and RNA Biology\, De
 partment of Biochemistry University of Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Personalised Medicine in Practice: Advances in Reproductive Scien
 ce    - Prof Thierry Voet (Associate Professor at the University of Leuv
 en\, Belgium & Associate Faculty Member\, Wellcome Trust Sanger Institute)
 \, Prof Cecilia Lindgren (University of Oxford)\, Dr. John Perry (Universi
 ty of Cambridge)\, prof. Joris Vermeesch (University of Leuven)\, Prof. Me
 linda Mills (University of Oxford)\, Prof. Michael Parker (University of O
 xford)\, Dr. Patricia Diaz-Gimeno (Valencia)\, Dr. Reedik Magi (University
  of  Tartu)\, Prof. Stephen Franks (Imperial College London)
DTSTART;VALUE=DATE-TIME:20170307T090000Z
DTEND;VALUE=DATE-TIME:20170308T173000Z
UID:https://talks.ox.ac.uk/talks/id/22576cb3-5a8e-400c-a23a-3106dd135a1e/
DESCRIPTION:Two days of national and international speakers focussing on m
 ethodology development and discoveries in the field of reproductive scien
 ce\nTopics to cover: - preimplantation genetic screening\n- biomarkers in 
 reproductive health: extra-cellular vesicles\n- integrated genomics in rep
 roductive traits\n- model systems in reproductive health ethics\n\nSpeaker
 s:\n Various Speakers
LOCATION:St Anne's College (Tsuzuki lecture theatre)\, Woodstock Road OX2 
 6HS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/22576cb3-5a8e-400c-a23a-3106dd135a1e/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Personalised Medicine in Practice: Advances in Reproduct
 ive Science    - Prof Thierry Voet (Associate Professor at the Universit
 y of Leuven\, Belgium & Associate Faculty Member\, Wellcome Trust Sanger I
 nstitute)\, Prof Cecilia Lindgren (University of Oxford)\, Dr. John Perry 
 (University of Cambridge)\, prof. Joris Vermeesch (University of Leuven)\,
  Prof. Melinda Mills (University of Oxford)\, Prof. Michael Parker (Univer
 sity of Oxford)\, Dr. Patricia Diaz-Gimeno (Valencia)\, Dr. Reedik Magi (U
 niversity of  Tartu)\, Prof. Stephen Franks (Imperial College London)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:The Africa Health Research Institute- a new multidisciplinary HIV 
 and TB centre in South Africa - Prof. Deenan Pillay (Africa Centre for Pop
 ulation Health)
DTSTART;VALUE=DATE-TIME:20170220T123000Z
DTEND;VALUE=DATE-TIME:20170220T133000Z
UID:https://talks.ox.ac.uk/talks/id/aee6f05a-5763-4fc8-aefb-aa52920de10e/
DESCRIPTION:The KwaZulu-Natal Research Institute for TB-HIV (K-RITH) and A
 frica Centre for Population Health have joined to form an exciting new int
 erdisciplinary research institute\, called the Africa Health Research Inst
 itute. They aim to become a source of fundamental discoveries into the sus
 ceptibility\, transmission and cure of HIV and TB and related diseases. Pr
 of Pillay will describe this new centre and opportunities for collaboratio
 n.\nSpeakers:\nProf. Deenan Pillay (Africa Centre for Population Health)
LOCATION:Wellcome Trust Centre for Human Genetics (Room B )\, Headington O
 X3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/aee6f05a-5763-4fc8-aefb-aa52920de10e/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:The Africa Health Research Institute- a new multidiscipli
 nary HIV and TB centre in South Africa - Prof. Deenan Pillay (Africa Centr
 e for Population Health)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Learning from the uncertain: modelling and forecasting infectious 
 disease dynamics  - Dr Sebastian Funk (London School of Hygiene & Tropical
  Medicine)
DTSTART;VALUE=DATE-TIME:20170110T130000Z
DTEND;VALUE=DATE-TIME:20170110T140000Z
UID:https://talks.ox.ac.uk/talks/id/495f9609-baeb-40f9-b243-50f4d5c93627/
DESCRIPTION:Forecasting the course of an outbreak can inform public health
  planning and decision making. Accurate forecasts\, however\, are hampered
  by uncertainty about changes in human behaviour\, pathogen genetics and e
 nvironmental factors that are difficult to capture in real time. I will pr
 esent a flexible framework based on Bayesian semi-mechanistic models that 
 can be used to incorporate these uncertainties. I will show how we used th
 is to produce regional forecasts during the West African Ebola epidemic of
  2014-16\, before discussing the applicability of our approach to a wider 
 class of problems. I will conclude with an outlook on the potential for an
 d challenges in using mathematical models to integrate different data sour
 ces for understanding and predicting the behaviour of infectious diseases.
 \n\nSpeakers:\nDr Sebastian Funk (London School of Hygiene & Tropical Medi
 cine)
LOCATION:Wellcome Trust Centre for Human Genetics (Room B)\, Headington OX
 3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/495f9609-baeb-40f9-b243-50f4d5c93627/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Learning from the uncertain: modelling and forecasting in
 fectious disease dynamics  - Dr Sebastian Funk (London School of Hygiene &
  Tropical Medicine)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:New mathematical models for estimating generalised HIV epidemics i
 n sub-Saharan Africa - Dr Jeff Eaton (Imperial College London)
DTSTART;VALUE=DATE-TIME:20170109T130000Z
DTEND;VALUE=DATE-TIME:20170109T140000Z
UID:https://talks.ox.ac.uk/talks/id/aa32298f-8367-48ac-ac60-aa73294ddc8d/
DESCRIPTION:Estimates of HIV epidemic trends in sub-Saharan Africa are gen
 erated by fitting a simple dynamic epidemic model to national data sources
  about HIV prevalence in a Bayesian framework\, to provide inference about
  population-wide trends in HIV prevalence\, new infections\, treatment nee
 d and coverage\, and other policy indicators.  In this talk I will (1) dis
 cuss motivating observations for revisiting the interpretation of widely r
 elied upon data sources for estimating HIV epidemic trends\, (2) describe 
 a new integrated demographic projection and HIV epidemic model for improvi
 ng HIV epidemic trends and projections in sub-Saharan Africa\, and (3) inv
 estigate the impact of accounting for biases on inferred HIV epidemic inci
 dence trends in sub-Saharan Africa. Finally\, I will discuss future opport
 unities\, challenges\, and considerations for combing next generation surv
 ey data and routine health facility data to generate more granular and rea
 l-time HIV estimates. \nSpeakers:\nDr Jeff Eaton (Imperial College London)
LOCATION:Wellcome Trust Centre for Human Genetics (Room A )\, Headington O
 X3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/aa32298f-8367-48ac-ac60-aa73294ddc8d/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:New mathematical models for estimating generalised HIV ep
 idemics in sub-Saharan Africa - Dr Jeff Eaton (Imperial College London)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Metabolomic and proteomic aberrations in diabetes: cause or conseq
 uence? - Associate Professor Tove Fall (Uppsala University)
DTSTART;VALUE=DATE-TIME:20170118T140000Z
DTEND;VALUE=DATE-TIME:20170118T150000Z
UID:https://talks.ox.ac.uk/talks/id/2fcfd89d-29d5-4c35-acd7-f7fec086fee0/
DESCRIPTION:Recent technical developments have enabled large-scale molecul
 ar analyses of biological samples\, such as the assessment of plasma metab
 olomics and proteomics. Some of these compounds have been found to be eith
 er increased or decreased in individuals with diabetes and pre-diabetes\, 
 but it is unclear whether these aberrations are part of the pathogenesis. 
 We and others have applied bi-directional Mendelian Randomization methods 
 in population-based cohorts and public genetic association data of metabol
 omics and glycemic traits to try to disentangle the causal directions. Giv
 en the vast effects of insulin on the metabolism\, it is not surprising to
  find genetic evidence that several of these aberrations are secondary to 
 insulin resistance. In many cases\, however\, especially for lipid metabol
 ites\, it has been difficult to find specific genetic instruments to asses
 s causality.\n\n\nSpeakers:\nAssociate Professor Tove Fall (Uppsala Univer
 sity)
LOCATION:Wellcome Trust Centre for Human Genetics (Room K )\, Headington O
 X3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/2fcfd89d-29d5-4c35-acd7-f7fec086fee0/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Metabolomic and proteomic aberrations in diabetes: cause 
 or consequence? - Associate Professor Tove Fall (Uppsala University)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Connecting genetic risk to disease endpoints through the human blo
 od plasma proteome - Prof. Dr. Karsten Suhre (Weill Cornell Medical Colleg
 e\, Qatar )
DTSTART;VALUE=DATE-TIME:20161201T140000Z
DTEND;VALUE=DATE-TIME:20161201T150000Z
UID:https://talks.ox.ac.uk/talks/id/30409e4c-74b8-4881-b858-260c8a807ba2/
DESCRIPTION:Genome-wide association studies (GWAS) with intermediate pheno
 types\, like changes in metabolite and protein levels\, provide functional
  evidence for mapping disease associations and translating them into clini
 cal applications. However\, although hundreds of genetic risk variants hav
 e been associated with complex disorders\, the underlying molecular pathwa
 ys often remain elusive. Associations with intermediate traits across mult
 iple chromosome locations are key in establishing functional links between
  GWAS-identified risk-variants and disease endpoints. Here\, we describe a
  GWAS performed with a highly multiplexed aptamer-based affinity proteomic
 s platform. We quantified associations between protein level changes and g
 ene variants in a German cohort and replicated this GWAS in an Arab/Asian 
 cohort. We identified many independent\, SNP-protein associations\, which 
 represent novel\, inter-chromosomal links\, related to autoimmune disorder
 s\, Alzheimer's disease\, cardiovascular disease\, cancer\, and many other
  disease endpoints. We integrated this information into a genome-proteome 
 network\, and created an interactive web-tool for interrogations. Our resu
 lts provide a basis for new approaches to pharmaceutical and diagnostic ap
 plications.\nSpeakers:\nProf. Dr. Karsten Suhre (Weill Cornell Medical Col
 lege\, Qatar )
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A&B)\, Headington
  OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/30409e4c-74b8-4881-b858-260c8a807ba2/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Connecting genetic risk to disease endpoints through the 
 human blood plasma proteome - Prof. Dr. Karsten Suhre (Weill Cornell Medic
 al College\, Qatar )
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Silicon Biosystems Seminar: DEPArray™ Digital Sorting to Resolve
  Heterogeneity on Low Input and Low Cellularity FFPE Tumors and Circulatin
 g Tumor Cells - Raimo Tanzi (Silicon Biosystems)
DTSTART;VALUE=DATE-TIME:20161117T120000Z
DTEND;VALUE=DATE-TIME:20161117T130000Z
UID:https://talks.ox.ac.uk/talks/id/1b920ef2-c870-4f1a-aa3d-2d9708c5fc59/
DESCRIPTION:DEPArray™ is the only sorting technology capable of isolatin
 g\, through a semiconductor controlled microfluidic chip\, 100% pure singl
 e or pooled cells. Single Circulating Tumor Cells can be isolated from enr
 iched blood\, pools of pure Tumor\, EMT\, TILs and Stromal cells can be is
 olated  from disaggregated FFPE tissue blocks\, as well as live cells can 
 be isolated from fresh tumor tissue.\n\nNGS Results show how interpretatio
 n of underlying genetic alterations becomes far clearer on samples transfo
 rmed into collections of pure or single cells\, not only improving the det
 ection of Somatic Mutations\, but enabling highly informative Copy Number 
 Aberration analysis on the pure cell populations.\n\nDuring the seminar we
  will present the principles of operation of the technology\, testing and 
 validation of the accuracy of the method with NGS panels and Whole Exome S
 equencing\, applications in the area of single CTC genetic analysis and FF
 PE tumor tissues.\n\nSpeakers:\nRaimo Tanzi (Silicon Biosystems)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Rooms A & B)\, 
 Headington OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/1b920ef2-c870-4f1a-aa3d-2d9708c5fc59/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Silicon Biosystems Seminar: DEPArray™ Digital Sorting t
 o Resolve Heterogeneity on Low Input and Low Cellularity FFPE Tumors and C
 irculating Tumor Cells - Raimo Tanzi (Silicon Biosystems)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Affymetrix Seminar - Claire Bloor (Affymetrix)\, Geoff Scopes (Aff
 ymetrix)
DTSTART;VALUE=DATE-TIME:20160928T130000
DTEND;VALUE=DATE-TIME:20160928T140000
UID:https://talks.ox.ac.uk/talks/id/1dce433c-ff05-4ecb-afa5-279711f3dd74/
DESCRIPTION:Please join us for an informative Affymetrix seminar presented
  by Claire Bloor and Geoff Scopes.\n\nClaire Bloor: Axiom Genotyping Speci
 alist\n\nMicrobial profiling made simple –detect viruses\, bacteria\, pr
 otozoa\, fungi and archaea in a single assay\nAffymetrix\, now part of The
 rmo Fisher will describe a how their new Axiom Microbiome Array can stream
 line your microbial profiling with species and strain level detection. The
  array has comprehensive coverage of five domains: archaea\, bacteria\, fu
 ngi\, protozoa and viruses (DNA and RNA viruses). The array has been desig
 ned with the Lawrence Livermore National Laboratory on a scalable platform
  with straightforward\, easy to use software.\n \n\nGeoff Scopes: Field Ap
 plications Specialist\n\nClariom™ assays: Next-generation transcriptome 
 profiling tools\nUnderstand it now:\nThe Clariom array-based approach gene
 rates Transcriptome results that are easy to analyze and interpret.\nWith 
 Clariom assays\, you won’t have to wait on answers. They are the ideal t
 ool for clinical and pre-clinical human disease research as well as large-
 cohort and biobank studies.\nTrust it now:\nWith comprehensive content der
 ived from the largest number of public databases\, trust that your discove
 ries are real and key biomarkers won’t be missed.\nClariom assays push t
 he boundaries of transcriptome analysis so you can push the boundaries of 
 your insights into human health.\nSpeakers:\nClaire Bloor (Affymetrix)\, G
 eoff Scopes (Affymetrix)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Rooms A & B\, U
 niversity of Oxford Roosevelt Drive\, Oxford\, OX3 7BN )\, Headington OX3 
 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/1dce433c-ff05-4ecb-afa5-279711f3dd74/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Affymetrix Seminar - Claire Bloor (Affymetrix)\, Geoff Sc
 opes (Affymetrix)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:CPM-WTCHG Biotech Career Workshop - Dr David Ruff (University of O
 xford SRF (visiting) )\, Dr Jon Sherlock (ThermoFisher)\, Dr Chris Spencer
  (University of Oxford)\, Dr Alice Barkell (Immunocore)
DTSTART;VALUE=DATE-TIME:20160629T111500
DTEND;VALUE=DATE-TIME:20160629T123000
UID:https://talks.ox.ac.uk/talks/id/227310e5-495a-4869-807a-685bb4d147b9/
DESCRIPTION:To inform young scientists about potential routes to becoming 
 independent researchers and the variety of career options available. This 
 workshop will focus on biotech careers. Speakers will briefly share the ch
 allenges and the rewards they have experienced in navigating their career 
 paths\, followed by Q & A. \nSpeakers:\nDr David Ruff (University of Oxfor
 d SRF (visiting) )\, Dr Jon Sherlock (ThermoFisher)\, Dr Chris Spencer (Un
 iversity of Oxford)\, Dr Alice Barkell (Immunocore)
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A & B)\, Headingt
 on OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/227310e5-495a-4869-807a-685bb4d147b9/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:CPM-WTCHG Biotech Career Workshop - Dr David Ruff (Univer
 sity of Oxford SRF (visiting) )\, Dr Jon Sherlock (ThermoFisher)\, Dr Chri
 s Spencer (University of Oxford)\, Dr Alice Barkell (Immunocore)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Counting on Illumina transition: Why RNASeq compared to Gene Expre
 ssion Arrays? - Scott Brouilette (Illumina)
DTSTART;VALUE=DATE-TIME:20160907T123000
DTEND;VALUE=DATE-TIME:20160907T133000
UID:https://talks.ox.ac.uk/talks/id/0c6b59ec-e8ce-4ebd-86d2-c6d7778d863a/
DESCRIPTION:Seminar - “Counting on Illumina: Transition”\nThe switch f
 rom expression arrays continues to gather pace. Since the seminal publicat
 ion describing the\napplication of NGS technology to gene expression analy
 sis in 2008 (Mortazavi 2008\, Nat. Methods) the\ncommunity has continued t
 o develop innovative methods to study RNA biology\, including single-cell 
 and\nribosomal profiling. But arguably the most powerful benefit of RNA-se
 q is its unbiased nature…\nKey Benefits or RNA-Seq:\n• Unbiased survey
  of transcription with the ability to identify novel\ntranscripts & isofor
 ms\n• Single-base resolution defines transcriptional boundaries & can re
 veal\nunderlying sequence variation\n• None of the background hybridisat
 ion issues with promiscuous probebinding\nwhen using arrays\n• A larger 
 dynamic range (typically 5-6 logs versus 3-4 for microarrays)\nDespite the
  advances in methodology and the benefits described above it has become ap
 parent there are\nstill some aspects of the technique that remain unclear.
  Therefore in this seminar we will review the\nprinciples of RNA-seq and d
 iscuss some key aspects of experimental design before deconstructing a\nnu
 mber of myths (using extensive and recent peer-reviewed data) including:\n
 Myth 1: “You need 200M reads to get meaningful data”\nFact 2: There ar
 e indeed experimental designs that may require 200M reads or more\, but to
 \nget data comparable to a generic 3’-array 10-20M single-end (SE) reads
  of 50bp\ncan suffice.\nMyth 2: “RNA-seq lacks reproducibly”\nFact 2: 
 This claim is likely linked to Myth 1\, as increasing read depth is often 
 viewed as the\nbest approach to improve statistical output. However both t
 echnical and biological\nreplicates are highly reproducible\, with sample 
 size a major influence.\nMyth 3: “Data analysis is too complex”\nFact 
 3: Data analysis pipelines differ from array-based methods\,\nbut Illumina
 ’s BaseSpace Sequence Hub offers cloud-based\nstorage & analysis with a 
 host of informatics tools wrapped\ninto a simple\, graphical user interfac
 e. Data can also be\nanalysed in R-studio via Illumina’s BaseMount tool\
 , or\ndownloaded for entry into in-house pipelines.\nSo please join us as 
 we take an end-to-end deep dive into this key application:\n• Overview o
 f NGS & Illumina Technology\n• Principles of RNA-Seq\, including experim
 ental design\n• Extensive Library Preparation options for RNA-Seq\n• D
 ata Analysis using BaseSpace Sequencing Hub\n\nSpeakers:\nScott Brouilette
  (Illumina)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Rooms A & B )\,
  Headington OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/0c6b59ec-e8ce-4ebd-86d2-c6d7778d863a/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Counting on Illumina transition: Why RNASeq compared to G
 ene Expression Arrays? - Scott Brouilette (Illumina)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Opportunities for Scaling Up Genetic Analysis - Prof Ben Neale (AT
 GU/MGH\, Broad Institute or Harvard and MIT)
DTSTART;VALUE=DATE-TIME:20160527T130000
DTEND;VALUE=DATE-TIME:20160527T140000
UID:https://talks.ox.ac.uk/talks/id/9b0c9bd1-270b-4e23-a27e-627074d50093/
DESCRIPTION:\nSpeakers:\nProf Ben Neale (ATGU/MGH\, Broad Institute or Har
 vard and MIT)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Rooms A & B)\, 
 Headington OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/9b0c9bd1-270b-4e23-a27e-627074d50093/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Opportunities for Scaling Up Genetic Analysis - Prof Ben 
 Neale (ATGU/MGH\, Broad Institute or Harvard and MIT)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Women in Science Series - Gayle Peterson (Saïd Business School)
DTSTART;VALUE=DATE-TIME:20160720T120000
DTEND;VALUE=DATE-TIME:20160720T130000
UID:https://talks.ox.ac.uk/talks/id/96b7e612-b054-4f42-9bb2-8a3310050d86/
DESCRIPTION:\nStatus: This talk has been cancelled\nMs Peterson is an Asso
 ciate Fellow of the Said Business School and Senior Managing Director for 
 pfc social impact advisors. Ms Peterson is focused on women and children a
 nd is examining how to connect the top trillion in resources with the bott
 om billion around the world who live in poverty in a way that is ethical a
 nd effective. Currently\, she is researching\, writing and putting togethe
 r an executive education curriculum about these issues to share best and n
 ext business practices with business and philanthropic executives to give 
 them the tools they need to create scalable and sustainable change.\nSpeak
 ers:\nGayle Peterson (Saïd Business School)
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A & B)\, Headingt
 on OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/96b7e612-b054-4f42-9bb2-8a3310050d86/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Women in Science Series - Gayle Peterson (Saïd Business 
 School)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:The Institute Josep Carreras: Research on Hematologic Neoplasms (H
 N) - Prof Evarist Feliu (Jose Carreras Institute)
DTSTART;VALUE=DATE-TIME:20160503T150000
DTEND;VALUE=DATE-TIME:20160503T160000
UID:https://talks.ox.ac.uk/talks/id/6077ac6e-2923-4e33-8097-709a83e6026f/
DESCRIPTION:The Institut Josep Carreras (IJC) promote the development of q
 uality research\, competitive and excellence as well as postgraduate train
 ing of high quality in the field of Hematologic Neoplasms (HN). This is on
 e of the few global centers exclusively dedicated to research on the HN. I
 JC Research Campus ICO-Hospital Germans Trias i Pujol (ICO-GTP)\, abbrevia
 ted GRIJC-ICO-GTP\, is a multidisciplinary group with different lines of r
 esearch related to the study of leukemias and other hematological malignan
 cies. \nSpeakers:\nProf Evarist Feliu (Jose Carreras Institute)
LOCATION:Wellcome Trust Centre for Human Genetics (Meeting Room A)\, Headi
 ngton OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/6077ac6e-2923-4e33-8097-709a83e6026f/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:The Institute Josep Carreras: Research on Hematologic Neo
 plasms (HN) - Prof Evarist Feliu (Jose Carreras Institute)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Imaging genomics of functional brain networks - Dr Jonas Richiardi
  (Standford University and University of Geneva)
DTSTART;VALUE=DATE-TIME:20160420T140000
DTEND;VALUE=DATE-TIME:20160420T150000
UID:https://talks.ox.ac.uk/talks/id/6e9bfa94-1804-4482-9028-8c68d6ecc8a6/
DESCRIPTION:During rest\, brain activity is intrinsically synchronized bet
 ween different brain regions\, forming networks of coherent activity. Thes
 e 'resting-state' functional networks (FNs)\, consisting of multiple regio
 ns widely distributed across lobes and hemispheres\, appear to be a fundam
 ental theme of neural organization in mammalian brains.\n\nPrevious work h
 as mostly focused on polymorphisms in candidate genes\, or used a twin stu
 dy approach to demonstrate heritability of aspects of resting-state connec
 tivity. The recent availability of high spatial resolution post-mortem bra
 in gene expression datasets\, together with several large-scale imaging ge
 netics datasets\, which contain joint in-vivo functional brain imaging dat
 a and genotype data for several hundred subjects\, opens intriguing data a
 nalysis avenues.\n\nUsing novel cross-modal graph-based statistics\, we sh
 ow that functional brain networks defined with resting-state fMRI can be r
 ecapitulated using measures of correlated gene expression\, and that the r
 elationship is not driven by gross tissue types. The set of genes we ident
 ify is significantly enriched for certain types of ion channels and synaps
 e-related genes. We validate results by showing that polymorphisms in this
  set significantly correlate with alterations of in-vivo resting-state fun
 ctional connectivity in a group of 259 adolescents. We further validate re
 sults on another species by showing that our list of genes is significantl
 y associated with neuronal connectivity in the mouse brain.  These results
  provide convergent\, multimodal evidence that resting-state functional ne
 tworks emerge from the orchestrated activity of dozens of genes linked to 
 ion channel activity and synaptic function.\nSpeakers:\nDr Jonas Richiardi
  (Standford University and University of Geneva)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Room A)\, Headi
 ngton OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/6e9bfa94-1804-4482-9028-8c68d6ecc8a6/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Imaging genomics of functional brain networks - Dr Jonas 
 Richiardi (Standford University and University of Geneva)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Super Cool NGS Things & Funky Clinical Stuff
DTSTART;VALUE=DATE-TIME:20160713T090000
DTEND;VALUE=DATE-TIME:20160713T170000
UID:https://talks.ox.ac.uk/talks/id/a604afb2-ce8c-401e-80f5-f38461b67e17/
DESCRIPTION:The 7th Oxford Genomics Forum is a 1-day event which takes pla
 ce on the Wednesday 13th July at the University of Oxford’s Old Road Cam
 pus.\n\nThis year the Forum is held in partnership between the Oxford Geno
 mics Centre and Biotexcel as a new platform to bring together genomic rese
 archers from diverse areas to discuss the latest advances\, technologies\,
  tools and directions in Genomics.  This new platform will evolve into a f
 ull 2-day event in 2017 so join us this year and be part of the community 
 as we take the popular forum to a new level.\n\nThe scientific theme of th
 e forum will cover the following areas:\n\nTechnological advancement in Si
 ngle Cell\nGenomic Medicine\nEpigenetics\nGene Regulation\nPathogenic Orga
 nisms\nCancer\nData analysis and handling\nThe Forum will consist of 3 key
 note talks given by opinion leaders who will then chair sessions of short 
 talks by key figures in those areas.  There will also be plenty of opportu
 nities for delegates to brainstorm ideas and discuss topics that are makin
 g the genomic headlines.\n\nA Panel Debate and a networking discussion wil
 l allow our experts and attendees to interact and ponder over topical issu
 es and bottlenecks such as how NGS labs are coping with the data deluge.\n
 \nWHO SHOULD ATTEND THIS NGS EVENT?\n\nAll NGS users\, researchers and stu
 dents in genomics\nBioinformaticians\nNHS & Private Labs\, Biotech Compani
 es\, CRO’s\, Service Providers\n   … and all those interested in the l
 atest developments of:\n\nBioinformatics\nBiomarkers\nComputational Biolog
 y\nData Analysis\nData interpretation\nDNA Sequencing\nGenetics/Genomics\n
 Infectious and Inherited Diseases\nInformatics\nMolecular and Cell Biology
 \nMolecular Diagnostics\nNext Generation Sequencing
LOCATION:Main Lecture theatre
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/a604afb2-ce8c-401e-80f5-f38461b67e17/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Super Cool NGS Things & Funky Clinical Stuff
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:WTCHG Post Doc Career Workshop - Dr Ross Chapman (University of Ox
 ford)\, Ellie Tzima (University of Oxford)\, Tzviya Zeev-Ben-Mordehai (Div
 ision of Structural Biology\, Oxford University)\, Dr Zamin Iqbal (Univers
 ity of Oxford)
DTSTART;VALUE=DATE-TIME:20160208T100000Z
DTEND;VALUE=DATE-TIME:20160208T113000Z
UID:https://talks.ox.ac.uk/talks/id/fcf4cf56-fbe0-4662-8da4-4559d9194200/
DESCRIPTION:\nStatus: This talk is in preparation - details may change\nTh
 e panel\, Dr Ross Chapman\, Dr Zam Iqbal\, Dr Ellie Tzima and Dr Tzviya Ze
 ev-Ben-Mordehai\,  will each give a short presentation sharing the challen
 ges and rewards they have experienced on the road to setting up their grou
 ps. After the presentations\, the floor will be opened to a Q & A session\
 , and followed by coffee\, tea and biscuits for informal chat with panelli
 sts.\n \nPlease advise Donna (brcpa@well.ox.ac.uk)\, if you would like to 
 attend (for catering purposes).\n \nEveryone welcome.  \nSpeakers:\nDr Ros
 s Chapman (University of Oxford)\, Ellie Tzima (University of Oxford)\, Tz
 viya Zeev-Ben-Mordehai (Division of Structural Biology\, Oxford University
 )\, Dr Zamin Iqbal (University of Oxford)
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A & B)\, Headingt
 on OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/fcf4cf56-fbe0-4662-8da4-4559d9194200/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:WTCHG Post Doc Career Workshop - Dr Ross Chapman (Univers
 ity of Oxford)\, Ellie Tzima (University of Oxford)\, Tzviya Zeev-Ben-Mord
 ehai (Division of Structural Biology\, Oxford University)\, Dr Zamin Iqbal
  (University of Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Running and Reading in Real Time - Looking at Squiggles on the Oxf
 ord Nanopore MinION
DTSTART;VALUE=DATE-TIME:20160122T120000Z
DTEND;VALUE=DATE-TIME:20160122T130000Z
UID:https://talks.ox.ac.uk/talks/id/67171425-8d2a-458f-8d59-e229572265c5/
DESCRIPTION:The utility of the Oxford nanopore MinION sequencer is becomin
 g clear. However\, to fully exploit its potential requires a shift in thou
 ght in both experimental design and analysis. The conventional model of se
 quence\, map and analysis leading to final result has been replaced by ins
 tant access to sequence data before the completion of a sequencing run. In
  the extreme case of the ONT MinION it is possible to analyse squiggle dat
 a before a read has even completed. We have developed a platform of tools\
 , minoTour\, to analyse MinION data in real time and extend it to exploit 
 both ‘Run Until’ and\, in future\, ‘Read Until’. Run until allows 
 the sequencer to switch off after achieving a specific goal\, such as dept
 h of coverage. Read until allows individual reads to be rejected from the 
 pore and free that pore to sequence an alternative preferred read. We have
  developed method for run and read until in a number of different scenario
 s including selective small genome sequencing on barcode normalization. Li
 mitations and challenges to implementing read until will be discussed alon
 g with the challenge of Fast Mode whereby speed of processing will be of v
 ital importance. Finally we demonstrate how methodologies for analysing sq
 uiggles may help to reduce the reliance on base calling in the field.
LOCATION:Wellcome Trust Centre for Human Genetics (Room B)\, Headington OX
 3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/67171425-8d2a-458f-8d59-e229572265c5/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Running and Reading in Real Time - Looking at Squiggles o
 n the Oxford Nanopore MinION
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:The Biomark™ HD System\, a Platform for Reliable Production-Scal
 e Throughput and Exquisite Single-Cell Sensitivity - Nick Jordan (Fluidigm
 )
DTSTART;VALUE=DATE-TIME:20151123T133000Z
DTEND;VALUE=DATE-TIME:20151123T143000Z
UID:https://talks.ox.ac.uk/talks/id/624c6825-9b79-41d6-8e5b-1f8569e96f01/
DESCRIPTION:Discover the BioMark™ HD System and its family of IFCs (inte
 grated fluidic circuits)\, offering flexible throughput\, from dozens up t
 o thousands of sample vs target combinations per run. \nWe will present it
 s use in multiple PCR applications\, including Gene Expression\, Genotypin
 g\, digital PCR and Copy Number Variation (CNV). \nWe will also discuss th
 e use of the Access Array Platform and it’s function in the preparation 
 of sequencing libraries for most current NGS platforms.\n\nIn conjunction 
 with this seminar the High Throughput Genomics lab at the Welcome Trust Ce
 ntre for Human Genetics and the Fluidigm Field Application Specialist will
  organise a training day on how to run a Gene expression project on the 96
 .96 IFC on the 24th of November 2015 with only limited place available so 
 if you are interested in running your own project in the future and learni
 ng on how to use the Biomark HD system\, please contact Dr Christine Blanc
 her to book a space as soon as possible by emailing: christin@well.ox.ac.u
 k\n\n\nThanks a lot and kind regards\,\n\nChristine\n\nDr Christine Blanch
 er\nHigh Throughput Arrays Manager\nHigh Throughput Genomics - Oxford Geno
 mic Centre \nWellcome Trust Centre for Human Genetics \nOxford University 
 \nRoosevelt Drive Oxford\nOX3 7BN\nTel: 01865 287632\nFax: 01865287587\nEm
 ail: christin@well.ox.ac.uk\nhttp://www.well.ox.ac.uk/ogc/home\n\nSpeakers
 :\nNick Jordan (Fluidigm)
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A and B)\, Headin
 gton OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/624c6825-9b79-41d6-8e5b-1f8569e96f01/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:The Biomark™ HD System\, a Platform for Reliable Produc
 tion-Scale Throughput and Exquisite Single-Cell Sensitivity - Nick Jordan 
 (Fluidigm)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Earliest Cortical Circuits - Prof Zoltan Molnar (Department of Phy
 siology\, Anatomy and Genetics\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20151125T130000Z
DTEND;VALUE=DATE-TIME:20151125T140000Z
UID:https://talks.ox.ac.uk/talks/id/ecd6539f-7881-4855-aefa-bea14fa10316/
DESCRIPTION:\nSpeakers:\nProf Zoltan Molnar (Department of Physiology\, An
 atomy and Genetics\, University of Oxford)
LOCATION:Richard Doll Building (Lecture Theatre)\, Old Road Campus OX3 7LF
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/ecd6539f-7881-4855-aefa-bea14fa10316/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Earliest Cortical Circuits - Prof Zoltan Molnar (Departme
 nt of Physiology\, Anatomy and Genetics\, University of Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:10xGenomics seminar: Long Range Applications with Short Read Seque
 ncing - Rob Tarbox (10xGenomics)
DTSTART;VALUE=DATE-TIME:20151116T150000Z
DTEND;VALUE=DATE-TIME:20151116T160000Z
UID:https://talks.ox.ac.uk/talks/id/63f19941-a330-40db-8989-81269c74faab/
DESCRIPTION:Dear all\,\n \nThe Oxford Genomics Centre would like to invite
  you to a seminar by 10xGenomics titled: Long Range Applications with Shor
 t Read Sequencing. The seminar will take place on Monday 16th November 201
 5 at 3.00pm in Room A at the Wellcome Trust Centre for Human Genetics. Spa
 ces are limited therefore it is highly recommended to register using the f
 ollowing link: https://www.eventbrite.co.uk/e/10xgenomics-long-range-appli
 cations-with-short-read-sequencing-tickets-19511043055 where you will find
  some information about the speaker Rob Tarbox. We are still awaiting an a
 bstract and the registration page will be updated as soon as we receive it
 .\n\nSpeakers:\nRob Tarbox (10xGenomics)
LOCATION:Wellcome Trust Centre for Human Genetics (Room B)\, Headington OX
 3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/63f19941-a330-40db-8989-81269c74faab/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:10xGenomics seminar: Long Range Applications with Short R
 ead Sequencing - Rob Tarbox (10xGenomics)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:A novel nanowell system based on SmartChip™ technology for the i
 solation and processing of 1000s of single cells - Dr Maithreyan Srinivasa
 n (Wafergen)
DTSTART;VALUE=DATE-TIME:20150922T143000
DTEND;VALUE=DATE-TIME:20150922T153000
UID:https://talks.ox.ac.uk/talks/id/42bfc9e5-c6a8-47d5-909b-bb75455e17cf/
DESCRIPTION:: Advances in Next-Generation Sequencing have increased our ab
 ility to work with small/precious samples and grow our understanding of ba
 sic biological principles.  Such biological insights are typically derived
  from data “averaged” over bulk cell and tissue samples.  However\, si
 ngle cell analyses suggest that cell-specific transcriptome differences ma
 y have profound functional consequences.  While technologies to isolate an
 d process hundreds of single cells have made progress\, advancements in si
 ngle cell biology require new technologies that can enhance and automate t
 he isolation and processing of tens of thousands of individual cells in a 
 selective and flexible manner.  \n                To satisfy this need\, w
 e have engineered a single-cell system (SCS) to accommodate a number of do
 wnstream applications including RNA-seq.  The WaferGen SCS includes a 5184
  nanowell array based on SmartChip™ technology\, imaging station\, multi
 -sample nano-dispenser (for accurate dispense of cells and reagents into n
 anowells) and an image-analysis software that can identify 1000s of single
 -cell containing wells in an automated fashion.  Using Poisson dispense me
 thod\, the WaferGen SCIS can routinely isolate up to ~1800 viable single c
 ells. Analysis of acquired chip images by proprietary software quickly eva
 luates cell staining to assess cell viability.  The image analysis softwar
 e is then used to select viable isolated cells for further processing.  We
 ll locations of selected cell are then uploaded to the dispenser to add re
 agents into wells of interest. This unique selective processing of individ
 ual cell-containing wells can dramatically help to minimize data analysis 
 noise from wells containing multiple cells.\n                The new Wafer
 Gen SCS moves the science of single-cell analysis forward by offering:  Po
 wer – up to 1800 viable cells/chip across the broadest range of cell typ
 es per sample (5-100um)\, Control – ability to selectively process ONLY 
 single-cell containing wells and Insight - process up to 8 samples per chi
 p. We present data that demonstrate the reproducible dispensing of individ
 ual cells/nuclei using preprinted oligonucleotide-barcodes and processing 
 of  the cells for RNA-seq.\n\nSpeakers:\nDr Maithreyan Srinivasan (Waferge
 n)
LOCATION:Wellcome Trust Centre for Human Genetics (Room A)\, Headington OX
 3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/42bfc9e5-c6a8-47d5-909b-bb75455e17cf/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:A novel nanowell system based on SmartChip™ technology 
 for the isolation and processing of 1000s of single cells - Dr Maithreyan 
 Srinivasan (Wafergen)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Women in Science - Prof Dame Carol Robinson (Dr Lee's Professor of
  Chemistry\, Physical and Theoretical Chemistry\, Oxford)
DTSTART;VALUE=DATE-TIME:20150930T120000
DTEND;VALUE=DATE-TIME:20150930T130000
UID:https://talks.ox.ac.uk/talks/id/f02f07fb-a63a-4459-b44e-00bf58109694/
DESCRIPTION:The aim of these sessions is for the speaker to share their ow
 n experience of a career in science & how they have balanced this career w
 ith lifestyle\, and for them to provide advice to scientists. \n\nProfesso
 r Robinson is the first female Professor of Chemistry at the University of
  Oxford and was previously the first female Professor of Chemistry at the 
 University of Cambridge.  She is renowned for pioneering the use of mass s
 pectrometry as an analytical tool and for her ground-breaking research  in
 to the 3D structure of proteins.\nSpeakers:\nProf Dame Carol Robinson (Dr 
 Lee's Professor of Chemistry\, Physical and Theoretical Chemistry\, Oxford
 )
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A & B)\, Headingt
 on OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f02f07fb-a63a-4459-b44e-00bf58109694/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Women in Science - Prof Dame Carol Robinson (Dr Lee's Pro
 fessor of Chemistry\, Physical and Theoretical Chemistry\, Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Women in Science - Prof Alison Noble (Dept of Engineering\, Oxford
 )
DTSTART;VALUE=DATE-TIME:20150701T120000
DTEND;VALUE=DATE-TIME:20150701T130000
UID:https://talks.ox.ac.uk/talks/id/fcc0e464-72fd-4131-8622-68e17e2e0050/
DESCRIPTION:The aim of these sessions is for the speaker to share their ow
 n experience of a career in science & how they have balanced this career w
 ith lifestyle\, and for them to provide advice to scientists. \n\nProfesso
 r Alison Noble OBE FREng is the Technikos Professor of Biomedical\nEnginee
 ring in the Oxford University Department of Engineering Science\, Director
  of the Institute for Biomedical Engineering (IBME)\, and a Fellow of St H
 ilda’s College\, Oxford. She is a Fellow of the UK IET\, a Fellow of the
  MICCAI Society\, and a Fellow of the Royal Academy of Engineering. She is
  also the current President of the MICCAI Society which is the internation
 al society in her field. She serves on numerous UK funding agency grant aw
 arding and advisory panels\, and a number of committees of the Royal Acade
 my of Engineering and Royal Society.  She was awarded an OBE for services 
 to Science and Engineering in the Queen’s Birthday Honours list in June 
 2013.\n\nProfessor Noble is a founding director of the Biomedical Image An
 alysis (BioMedIA)\nLaboratory based at the Oxford IBME\; a multi-disciplin
 ary research group working in the area of biomedical imaging and image ana
 lysis\, an important sub-discipline of modern biomedical engineering. She 
 heads a large research activity in cardiovascular image analysis\, women
 ’s health imaging (obstetrics and perinatal care) and microscopy image a
 nalysis. She is also Chief Technology Officer of Intelligent Ultrasound Lt
 d\, a spin-out company from her laboratory. Throughout her career she has 
 combined research with training early career researchers\, playing an infl
 uential role in setting up biomedical engineering education programmes at 
 the undergraduate and postgraduate level at Oxford\, and personally having
  supervised or co-supervised 49 PhD students to successful completion to-d
 ate.\nSpeakers:\nProf Alison Noble (Dept of Engineering\, Oxford)
LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A & B)\, Headingt
 on OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/fcc0e464-72fd-4131-8622-68e17e2e0050/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Women in Science - Prof Alison Noble (Dept of Engineering
 \, Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Biomarker Development for Immuno-Oncology and Cancer immunotherapy
 : Simultaneous Digital Counting of Nucleic-Acids and Proteins at 800-Plex 
 - Dr Joseph Beechem (Nanostring Technologies Inc)
DTSTART;VALUE=DATE-TIME:20150608T120000
DTEND;VALUE=DATE-TIME:20150608T130000
UID:https://talks.ox.ac.uk/talks/id/fd93b596-771c-464a-90dd-b78a91fce2e4/
DESCRIPTION:Both the ENCODE and TCGA projects highlighted the value of qua
 ntifying multiple biomarker classes (DNA\, RNA\, and protein) from cancer 
 tumor samples. In the case of cancer immunotherapy\, the importance of mea
 suring non-DNA markers (e.g.\, mRNA and proteins) becomes crucial since ce
 ll signaling\, tumor microenvironment\, and protein-protein interactions d
 ominate over pure SNP-based (DNA) driver mutations in determining therapeu
 tic response. Combining multiple data types together into a single correla
 ted analysis\, however\, is adversely effected by the drastically differen
 t methodologies utilized for measurement. For example\, the fluorescence s
 ignal intensity obtained from a camera imaging a protein array (e.g.\, RPP
 A) is very difficult to correlate directly with an RNA sequencing count of
  a clonally amplified\, cDNA-converted\, mRNA molecule. New developments i
 n multiple biomarker-class optical barcode counting significantly reduce t
 his problem. Recent developments using NanoString Technology has shown how
  optical barcode technology can be utilized for multiplexed digital counti
 ng of proteins and be combined with simultaneous digital counting of nucle
 ic acids on a single platform. \nSpeakers:\nDr Joseph Beechem (Nanostring 
 Technologies Inc)
LOCATION:Wellcome Trust Centre for Human Genetics (Room A and B)\, Heading
 ton OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/fd93b596-771c-464a-90dd-b78a91fce2e4/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Biomarker Development for Immuno-Oncology and Cancer immu
 notherapy: Simultaneous Digital Counting of Nucleic-Acids and Proteins at 
 800-Plex - Dr Joseph Beechem (Nanostring Technologies Inc)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Routine molecular subgrouping of medulloblastoma: Bridging the div
 ide between research and the clinic using low-cost DNA methylomics - Dr Ed
  Schwalbe (Newcastle Cancer Centre)
DTSTART;VALUE=DATE-TIME:20150610T123000
DTEND;VALUE=DATE-TIME:20150610T133000
UID:https://talks.ox.ac.uk/talks/id/26b57b8a-97fd-4403-9f45-b33da0567c41/
DESCRIPTION:Background: DNA-methylation patterns allow the subclassificati
 on of medulloblastoma\, the most common childhood malignant brain tumour\,
  into four molecular subgroups (WNT\, SHH\, MBGrp3 and MBGrp4).  These sub
 groups have distinct molecular and clinico-pathological features\, and the
 ir distinction is now informing future treatments and risk-stratification.
  Whilst microarrays to assign subgroup are suitable for research purposes\
 , they are limited by expense\, platform-specificity\, sample quality requ
 irements and practicality. Here\, we aimed to develop a low-cost\, array-i
 ndependent\, robust subgrouping assay suitable for routine quality-control
 led subclassification\, including scant and poor-quality samples.  \nMetho
 ds:\nA minimal\, multiply-redundant\, 17-locus methylation signature was d
 erived to assign subgroup\, using Illumina 450k DNA-methylation array data
  and subgroup calls from 253 medulloblastomas. A cross-validated machine-l
 earning classifier was developed to assign subgroup using these loci. We n
 ext investigated whether bisulfite treatment of DNA could induce methylati
 on-dependent SNPs suitable for multiplexed interrogation of methylation st
 atus\, using an adaptation of Sequenom's iPlex assay. Multiplexed primer-m
 ixes were designed and quantitation validated using molar-ratios of bisulf
 ite-treated methylated:unmethylated DNA. Subsequently\, the assay was run 
 on 101 DNA extracts from fresh-frozen\, FFPE and cytospin (<30\,000 nuclei
 ) tumour material\, representing all subgroups. Subgroup assignments by Se
 quenom assay were compared to gold standard 450k array calls.\nResults:\nV
 alidation using molar-ratios of methylated:unmethylated DNA demonstrated c
 lose concordance between methylation-ratios and Sequenom methylation estim
 ates at all loci. Subsequently\, 95/103 (92%) medulloblastomas tested were
  assigned with high confidence to the same subgroup by both Sequenom and 4
 50k assays. \nConclusions:\nMedulloblastomas can be routinely subgrouped u
 sing minimal DNA-methylation signatures. The assay is suitable for reliabl
 e\, robust subgroup assignation from poor-quality\, degraded samples using
  100ng of DNA. The assay's low-cost\, rapidity (3 days from extraction to 
 result) and application to single samples demonstrate its potential for ro
 utine use. This first demonstration of multiplexed\, methylation-based Seq
 uenom subtyping holds rich promise for future molecular subclassification 
 and prognostication across diverse tumour types.\n\nSchwalbe\, E.C.1\, Hic
 ks\, D. 1 \, Rafiee\, G. 1\,Gohlke\, H. 2\, Enshaei\, A. 1\, Potluri\, S. 
 1\, Matthiesen\, J. 1\, Mather\, M. 1\, Chaston\, R.3\, Crosier\, S. 1\, S
 mith\, A.J. 1\, Williamson\, D. 1\, Bailey\, S. 1\, Clifford\, S.C. 1\n\n1
 Northern Institute for Cancer Research\, Newcastle University\, Newcastle 
 upon Tyne\, U.K.\n2Agena BioSciences\, Hamburg\, Germany\n3NewGene\, Newca
 stle upon Tyne\, U.K.\nSpeakers:\nDr Ed Schwalbe (Newcastle Cancer Centre)
LOCATION:Wellcome Trust Centre for Human Genetics (Room B)\, Headington OX
 3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/26b57b8a-97fd-4403-9f45-b33da0567c41/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Routine molecular subgrouping of medulloblastoma: Bridgin
 g the divide between research and the clinic using low-cost DNA methylomic
 s - Dr Ed Schwalbe (Newcastle Cancer Centre)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:'Embryonic Stem Cells: Capture of the Ground State' - Prof. Austin
  Smith (Principal Investigator – Stem Cell Potency\, Wellcome Trust Cent
 re – Medical Research Council\, Cambridge Stem Cell Institute\, Universi
 ty of Cambridge)
DTSTART;VALUE=DATE-TIME:20150220T120000Z
DTEND;VALUE=DATE-TIME:20150220T131500Z
UID:https://talks.ox.ac.uk/talks/id/44f10062-2a43-40f7-9d15-209d3cfe4a8c/
DESCRIPTION:Pluripotency\, the capacity to generate all cell types of the 
 body\, lies at the foundation of development in mammals. In 1981 scientist
 s discovered that pluripotency could be maintained in the laboratory in ce
 lls called embryonic stem cells. Study of these unique cells over the past
  30 years has uncovered the molecular machinery that governs pluripotency.
  These studies have also highlighted significant differences between ES ce
 lls from rodents and from humans. So what makes an authentic embryonic ste
 m cell?\n\nhttp://www.stemcells.cam.ac.uk/researchers/principal-investigat
 ors/pressor-austin-smith\nSpeakers:\nProf. Austin Smith (Principal Investi
 gator – Stem Cell Potency\, Wellcome Trust Centre – Medical Research C
 ouncil\, Cambridge Stem Cell Institute\, University of Cambridge)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Rooms A/B)\, He
 adington OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/44f10062-2a43-40f7-9d15-209d3cfe4a8c/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:'Embryonic Stem Cells: Capture of the Ground State' - Pro
 f. Austin Smith (Principal Investigator – Stem Cell Potency\, Wellcome T
 rust Centre – Medical Research Council\, Cambridge Stem Cell Institute\,
  University of Cambridge)
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