BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:A rate-limiting process: T cell activation from a single-cell pers
 pective   - Dr Arianne Richard (University of Cambridge)
DTSTART;VALUE=DATE-TIME:20200907T140000
DTEND;VALUE=DATE-TIME:20200907T150000
UID:https://talks.ox.ac.uk/talks/id/ad087344-6e79-4766-a049-b52c1bf64a4f/
DESCRIPTION:Cytotoxic T lymphocytes (CTLs) are critical for defense agains
 t intracellular pathogens and cancer. CTL differentiation begins when a na
 ïve CD8+ T cell recognizes a peptide-MHC ligand complex through its T cel
 l receptor (TCR)\, triggering a cascade of activation events. The interact
 ion of the TCR with a particular peptide-MHC complex is exquisitely sensit
 ive\, such that single amino acid changes in the presented peptide can dra
 matically alter the activation of responding T cells. Multiple mechanisms 
 have been proposed to underlie this phenomenon\, but these cannot be disti
 nguished through snapshot measurements in bulk cellular populations. In th
 is talk\, I will describe how we address this using multidimensional measu
 rements (single-cell RNAseq and mass cytometry) of molecular activation ev
 ents in individual cells over time.\nSpeakers:\nDr Arianne Richard (Univer
 sity of Cambridge)
LOCATION:Kennedy Institute of Rheumatology (This seminar will be held usin
 g Zoom. Please register here:  https://zoom.us/meeting/register/tJYocuGupz
 gpGtQi_Iz7Yd_vTyQvP8eeUbAc )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/ad087344-6e79-4766-a049-b52c1bf64a4f/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:A rate-limiting process: T cell activation from a single-
 cell perspective   - Dr Arianne Richard (University of Cambridge)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR