BEGIN:VCALENDAR VERSION:2.0 PRODID:talks.ox.ac.uk BEGIN:VEVENT SUMMARY:The structures and mechanisms that maintain ciliary proteostasis - Prof Alan Brown (Harvard Medical School) DTSTART;VALUE=DATE-TIME:20250916T140000 DTEND;VALUE=DATE-TIME:20250916T150000 UID:https://talks.ox.ac.uk/talks/id/b1127cd4-a56f-47fe-be9a-da2cbdd1988d/ DESCRIPTION:Alan Brown is an Associate Professor of Biological Chemistry a nd Molecular Pharmacology at Harvard Medical School. He obtained his PhD i n 2010 from the University of Cambridge before doing postdocs with Dr. Mat thew Higgins and Dr. Venki Ramakrishnan. He started his lab in 2017 and wa s named a Pew Scholar in 2019. His laboratory uses structural and cell bio logical techniques to study cilia and flagella\, with a particular emphasi s on elucidating the mechanisms of ciliary motility\, intraflagellar trans port\, and the regulation of the ciliary proteome.\nSpeakers:\nProf Alan B rown (Harvard Medical School) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/b1127cd4-a56f-47fe-be9a-da2cbdd1988d/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The structures and mechanisms that maintain ciliary prote ostasis - Prof Alan Brown (Harvard Medical School) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Mechanisms of co-translational folding and assembly of proteins - Prof Bernd Bukau (University of Heidelberg) DTSTART;VALUE=DATE-TIME:20250411T140000 DTEND;VALUE=DATE-TIME:20250411T150000 UID:https://talks.ox.ac.uk/talks/id/e93fa8a7-3577-4d92-ae05-998faca2aa88/ DESCRIPTION:\nSpeakers:\nProf Bernd Bukau (University of Heidelberg) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/e93fa8a7-3577-4d92-ae05-998faca2aa88/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Mechanisms of co-translational folding and assembly of pr oteins - Prof Bernd Bukau (University of Heidelberg) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Characterising human proteome diversity in health and disease - Pr of Angus Lamond (University of Dundee) DTSTART;VALUE=DATE-TIME:20241004T140000 DTEND;VALUE=DATE-TIME:20241004T150000 UID:https://talks.ox.ac.uk/talks/id/310f7539-1f14-4c72-83f3-77f815452bfb/ DESCRIPTION:Professor Angus I. Lamond FRS FRSE FMed Sci is an RNA biochemi st and molecular cell biologist working at the University of Dundee\, Scho ol of Life Sciences. Angus has a PhD from the University of Cambridge\, wh ere he worked on the regulation of bacterial transcription at the L.M.B. A s a postdoctoral fellow with Phillip Sharp in the Center for Cancer Resear ch at M.I.T.\, Angus began working on RNA processing and the mechanism of pre-mRNA splicing in human cells. As a group leader at the European Molecu lar Biology Laboratory in Heidelberg\, Angus continued working on biochemi cal mechanisms involved in RNA processing and alternative splicing\, which led on to him studying the functional organisation of subnuclear bodies i n mammalian cells\, aiming to understand how nuclear structure coordinates the processing of pre-mRNAs and pre-rRNAs. While at EMBL\, he was introdu ced by Matthias Mann to the analysis of proteins using mass spectrometry a nd in collaboration with the Mann group pioneered the proteomic analysis o f RNA processing complexes and nuclear bodies. Since moving to the Univers ity of Dundee\, the Lamond group have continued to study mechanisms involv ed in alternative splicing and human disease\, using a combination of meth ods spanning quantitative proteomics\, microscopy and in vitro biochemical assays. The Lamond group also study the impact of human genetic diversity at the protein level and how this affects cellular phenotypes and disease mechanisms.\nSpeakers:\nProf Angus Lamond (University of Dundee) LOCATION:Sir William Dunn School of Pathology (EPA Seminar room )\, South Parks Road OX1 3RE TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/310f7539-1f14-4c72-83f3-77f815452bfb/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Characterising human proteome diversity in health and dis ease - Prof Angus Lamond (University of Dundee) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Rare Disease Patient-Led Functional Genomics- A Tale of Tubulins - Dr Pleasantine Mill (University of Edinburgh) DTSTART;VALUE=DATE-TIME:20240607T140000 DTEND;VALUE=DATE-TIME:20240607T150000 UID:https://talks.ox.ac.uk/talks/id/8eed3b76-1eaa-4926-a9fa-6a31634becb4/ DESCRIPTION:Prof Pleasantine Mill is an MRC Investigator at the MRC Human Genetics Unit at the University Edinburgh\, UK where she leads a programme to understand genetic disease and disease mechanisms arising from dysfunc tion of mammalian cilia\, called the ciliopathies. With 20 years of expert ise in developmental genetics and cell biology\, her work spans from forwa rd genetics screens through to candidate discovery in human disease geneti cs. Her lab focuses on phenotype-driven projects which disrupt cilia struc ture and/or function to undercover underlying genetic changes\, understand disease mechanisms and move towards much needed therapeutics for rare dis eases. Her novel in vivo work can be summed up as ‘cell biology on an or ganismal scale’. Her lab harnesses quantitative imaging across biologica l scales (from light microscopy through to electron microscopy) to underst and how different types of mammalian cilia are assembled and maintained\, and how they are disrupted by disease-causing mutations. Her work is funde d by the UK Medical Research Council\, NIHR\, LifeArc and the European Res earch Council\nSpeakers:\nDr Pleasantine Mill (University of Edinburgh) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/8eed3b76-1eaa-4926-a9fa-6a31634becb4/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Rare Disease Patient-Led Functional Genomics- A Tale of T ubulins - Dr Pleasantine Mill (University of Edinburgh) TRIGGER:-PT1H END:VALARM END:VEVENT END:VCALENDAR