BEGIN:VCALENDAR VERSION:2.0 PRODID:talks.ox.ac.uk BEGIN:VEVENT SUMMARY:BRC3 Gastroenterology and Mucosal Immunity Theme Seminars - Alison Simmons\, Graham Ogg DTSTART;VALUE=DATE-TIME:20170621T120000 DTEND;VALUE=DATE-TIME:20170621T130000 UID:https://talks.ox.ac.uk/talks/id/b217f817-c0ff-47b9-8afe-4e2bd6c7b6fa/ DESCRIPTION:\nSpeakers:\nAlison Simmons\, Graham Ogg LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/b217f817-c0ff-47b9-8afe-4e2bd6c7b6fa/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:BRC3 Gastroenterology and Mucosal Immunity Theme Seminars - Alison Simmons\, Graham Ogg TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Role of DNA damage signaling machinery in innate immune regulation - Professor Nelson Gekara (Department of Molecular Biology\, Umeå Unive rsity) DTSTART;VALUE=DATE-TIME:20160913T110000 DTEND;VALUE=DATE-TIME:20160913T120000 UID:https://talks.ox.ac.uk/talks/id/6173e959-43e7-4f88-813b-27a83bd85c2f/ DESCRIPTION:\nSpeakers:\nProfessor Nelson Gekara (Department of Molecular Biology\, Umeå University) LOCATION:MRC Weatherall Institute of Molecular Medicine (WIMM Seminar room )\, Headington OX3 9DS TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/6173e959-43e7-4f88-813b-27a83bd85c2f/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Role of DNA damage signaling machinery in innate immune r egulation - Professor Nelson Gekara (Department of Molecular Biology\, Ume å University) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:The Role of TL1A/DR3 in Intestinal Inflammation - Dr Fabio Comine lli (Professor\, Departments of Medicine and Pathology\, Director of the C WRU/UH Digestive Health Centre\, USA) DTSTART;VALUE=DATE-TIME:20160120T133000Z DTEND;VALUE=DATE-TIME:20160120T143000Z UID:https://talks.ox.ac.uk/talks/id/15812356-63b9-4f27-878b-dc506908790a/ DESCRIPTION:Biography \nFabio Cominelli\, MD\, PhD\, is Professor of Medic ine and Pathology\, Chief of the Division of Gastroenterology and Liver Di sease\, and Director of the Digestive Health Research Institute at Case We stern Reserve University (CWRU) and University Hospitals of Cleveland. He is also the inaugural awardee of the Hermann Menges Jr Chair in Internal Medicine and Associate Dean for Program Development. Dr. Cominelli is the Principal Investigator (PI) and Director of a National Institutes of Heal th (NIH) Program Project Grant\, studying the role of innate immunity in e xperimental Crohn’s disease\, and two R01 grants focused on the role of cytokines and commensal flora in the pathogenesis of intestinal inflammati on. He is also the PI of a T32 Training grant in Digestive Disease Scienc es at CWRU\, as well as the PI and Director of the Cleveland NIH Digestive Diseases Research Core Center. \nHis research interest in the area of exp erimental inflammatory bowel disease and intestinal cytokines dates back 2 8 years to his fellowship in Gastroenterology research under Dr. Robert Zi pser at Harbor UCLA Medical Center. These two general areas of research h ave remained the focus of his investigation ever since. In recognition of his research accomplishments\, Dr. Cominelli was the recipient of the 200 2 Outstanding Investigator Award from the American Federation for Medical Research for his studies establishing that targeted neutralization of a sp ecific cytokine was effective for the treatment of experimental IBD. Dr. Cominelli has over 25 years of experience and continuous NIH funding in cy tokine biology and many seminal discoveries in this field of investigation . His group was the first to report that specific blockade of a single pr o-inflammatory cytokine\, i.e. interleukin-1 (IL-1)\, was effective in red ucing disease severity in an animal model of experimentally-induced coliti s and that an imbalance between intestinal pro- and anti-inflammatory cyto kines represents a pathogenic mechanism of auto-inflammatory diseases\, in cluding IBD. This concept has now gained considerable attention through re ports of severe inflammatory disease in infants with homozygous germ-line mutations in the IL-1 gene family. These and other studies have formed th e foundation for clinical trials using anti-cytokine therapy (e.g. anti-TN Fα therapy) as well as administration of anti-inflammatory cytokines\, (e .g. IL-1 receptor antagonist) in patients with auto-inflammatory diseases. Dr. Cominelli has published more than 150 articles and has extensive expe rience as a journal reviewer. He has been an Associate Editor and an Edit orial Board Member for several Journals including the Journal of Immunolog y\, Gastroenterology\, Digestive and Liver Disease\, The American Journal of Physiology and others. He is currently an Academic Editor for PLoS One and Associate Editor for Translational Research. Dr. Cominelli has been also an outstanding mentor and has trained more than 120 individuals many of them being independent investigators or academic leaders in Gastroenter ology. \n \nDr. Cominelli is also a highly respected clinician with strong expertise in clinical program development for the diagnosis and treatment of patients with digestive diseases. He has been named “American Top D octor” in Gastroenterology by Castle Connonly Medical Ltd (2001-2016)\, “Best Doctor” in Gastroenterology\, by the Cleveland Magazine (2009-20 16)\, “Best Doctor in Gastroenterology (top 1%)”\, by US News & World Report (2012-2016) and “Super Doctor in Gastroenterology” by Key Profe ssional Media (2012-2016).\n\n\nSpeakers:\nDr Fabio Cominelli (Professor\, Departments of Medicine and Pathology\, Director of the CWRU/UH Digestive Health Centre\, USA) LOCATION:Lecture Theatre 1\, Academic Corridor\, Level 3\, John Radcliffe Hospital TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/15812356-63b9-4f27-878b-dc506908790a/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The Role of TL1A/DR3 in Intestinal Inflammation - Dr Fab io Cominelli (Professor\, Departments of Medicine and Pathology\, Director of the CWRU/UH Digestive Health Centre\, USA) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:ER Stress and Autophagy Conspiring in the Crohn's Disease Epitheli um - Prof Arthur Kaser (Head\, Div of Gastroenterology and Hepatology\, Ca mbridge University Hospitals) DTSTART;VALUE=DATE-TIME:20151111T133000Z DTEND;VALUE=DATE-TIME:20151111T143000Z UID:https://talks.ox.ac.uk/talks/id/8a620ac6-d39b-45db-91d0-f9b80c582d9a/ DESCRIPTION:\nSpeakers:\nProf Arthur Kaser (Head\, Div of Gastroenterology and Hepatology\, Cambridge University Hospitals) LOCATION:MRC Weatherall Institute of Molecular Medicine (Seminar Room)\, H eadington OX3 9DS TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/8a620ac6-d39b-45db-91d0-f9b80c582d9a/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:ER Stress and Autophagy Conspiring in the Crohn's Disease Epithelium - Prof Arthur Kaser (Head\, Div of Gastroenterology and Hepato logy\, Cambridge University Hospitals) TRIGGER:-PT1H END:VALARM END:VEVENT END:VCALENDAR