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SUMMARY:Proteolysis-mediated regulation of red blood cell maturation - Dr 
 Arno Alpi (University of Edinburgh)
DTSTART;VALUE=DATE-TIME:20250902T130000
DTEND;VALUE=DATE-TIME:20250902T140000
UID:https://talks.ox.ac.uk/talks/id/c49a0ab9-5764-44f1-a2a9-d753a05215d8/
DESCRIPTION:Biography – Arno Alpi received his PhD at the Max-Planck Ins
 titute of Biochemistry and the Ludwig-Maximilian University of Munich\, fo
 llowed by a Postdoctoral study at the MRC-LMB\, Cambridge with Prof KJ Pat
 el\, where Arno got interested in ubiquitin-mediated cell signalling in DN
 A damage response and the chromosome instability syndrome\, Fanconi Anaemi
 a. He then headed labs at the MRC-PPU\, University of Dundee\, and the Max
 -Planck Institute of Biochemistry\, Munich\, before moving back to Scotlan
 d in spring 2024 to join the Institute of Cell Biology at the University o
 f Edinburgh. His current research interests focus on haematopoiesis and on
  how the ubiquitin system\, in particular the multiprotein CTLH E3 ligase\
 , modulates metabolism and gene regulation in red blood cell development.\
 n\nRecent publications – \n•	Gottemukkala KV\, Chrustowicz J\, Sherpa 
 D\, Sepic S\, Vu DT\, Karayel Ö\, Papadopoulou EC\, Gross A\, Schorpp K\,
  von Gronau S\, Hadian K\, Murray PJ\, Mann M\, Schulman BA\, Alpi AF (202
 4) “Non-canonical substrate recognition by the human WDR26-CTLH E3 ligas
 e regulates prodrug metabolism” Mol Cell. 2024 May 16\;84(10):1948-1963.
 e11.doi:10.1016/j.molcel.2024.04.014.\n\n•	Sherpa D\, Müller J\, Karaye
 l Ö\, Chrustowicz J\, Xu P\, Yao Y\, Gottemukkala KV\, Baumann C\, Gross 
 A\,Czarnezki O\, Zhang W\, Gu J\, Nilvebrant J\, Weiss MJ\, Sidhu SS\, Mur
 ray PJ\, Mann M\, Schulman BA\, Alpi AF (2022) “Modular UBE2H-CTLH E2-E3
  complexes regulate erythroid maturation” eLife 2022\;11:e77937\n\n•	K
 arayel O\, Xu P\, Bludau I\, Bhoopalan SV\, Yao Y\, Freitas Colaco AR\, De
 lgado AS\, Schulman BA#\, Alpi AF#\, Weiss MJ#\, Mann M#. (2020) “Integr
 ative proteomics reveals principles of dynamic phospho-signaling networks 
 in human erythropoiesis” (#Co-corresponding authorship). Mol Syst Biol. 
 (EMBO Press) 16(12):e9813. doi: 10.15252/msb.20209813.\nSpeakers:\nDr Arno
  Alpi (University of Edinburgh)
LOCATION:MRC Weatherall Institute of Molecular Medicine (WIMM Seminar Room
 )\, Headington OX3 9DS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/c49a0ab9-5764-44f1-a2a9-d753a05215d8/
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DESCRIPTION:Talk:Proteolysis-mediated regulation of red blood cell maturat
 ion - Dr Arno Alpi (University of Edinburgh)
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