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SUMMARY:Understanding macrophage functional heterogeneity in the injured l
 iver - Professor Charlotte Scott (VIB-UGent Center for Inflammation Resear
 ch)
DTSTART;VALUE=DATE-TIME:20231124T150000Z
DTEND;VALUE=DATE-TIME:20231124T160000Z
UID:https://talks.ox.ac.uk/talks/id/07c3ac3a-8ae2-4755-b446-9a0b48ee3099/
DESCRIPTION:A transient and spatially-restricted subset of resident Kupffe
 r Cells induced by lipid uptake.\n\nAnna Bujko*\, Federico F. De Ponti*\, 
 Zhuangzhuang Liu\, Paul Collins\, Tinne Thoné\, Liesbet Martens\, Bavo Va
 nneste & Charlotte L. Scott.\n\n*These authors contributed equally\n\nMyel
 oid Cell Biology in Tissue Damage and Inflammation\, VIB-UGent Center for 
 Inflammation Research\, Belgium\n\nIn recent years the plasticity of tissu
 e-resident macrophages (ms) has been questioned. Fitting with the idea 
 that resident ms may not be as plastic as once thought\, we have recent
 ly demonstrated that liver-resident Kupffer cells (KCs) do not display any
  overt activation in the context of fatty liver disease. However\, this ha
 s been challenged using different models of NAFLD and whether this holds t
 rue in other inflammatory contexts has also not been assessed. To investig
 ate this\, we employed a combination of spatial proteogenomics techniques 
 to assess hepatic m heterogeneity over time during non-alcoholic fatty 
 liver disease (NAFLD)\, acetaminophen-induced liver injury (AILI) and chro
 nic fibrosis. Consistent with previous reports\, we observed a significant
  infiltration of monocyte-derived ms in these models\, that were lost u
 pon return to homeostasis. Further examination of the KC pool revealed the
  emergence of a subpopulation of resident KCs present only in the in vivo 
 digested samples. This subset of KCs expressed a selection of genes previo
 usly associated with recruited lipid-associated macrophages (LAMs) includi
 ng Trem2 and Cd36. These LAM-like KCs were uniquely positioned around dama
 ged tissue likely explaining the difficulties in isolating these cells. Fu
 rther analysis of the LAM-like KC phenotype did not reveal any increased a
 ctivation in terms of pro or anti-inflammatory cytokine expression. Fittin
 g with the LAM-like signature\, we found that lipid uptake\, primarily thr
 ough efferocytosis is important for the generation of this phenotype. We a
 re currently investigating the relevance of the different macrophage subse
 ts in disease progression. \nSpeakers:\nProfessor Charlotte Scott (VIB-UGe
 nt Center for Inflammation Research)
LOCATION:IMS-Tetsuya Nakamura Building (Seminar Rooms)\, Roosevelt Dr\, He
 adington OX3 7TY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/07c3ac3a-8ae2-4755-b446-9a0b48ee3099/
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DESCRIPTION:Talk:Understanding macrophage functional heterogeneity in the 
 injured liver - Professor Charlotte Scott (VIB-UGent Center for Inflammati
 on Research)
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