BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:AMPK phosphorylation of FNIP1 dictates the kinetics of lysosome an
 d mitochondrial biogenesis - Dr Nazma Malik (Salk Institute)
DTSTART;VALUE=DATE-TIME:20230803T150000
DTEND;VALUE=DATE-TIME:20230803T160000
UID:https://talks.ox.ac.uk/talks/id/3f009131-2941-4450-ae59-310395779272/
DESCRIPTION:Cells respond to mitochondrial poisons with rapid activation o
 f the adenosine monophosphate-activated protein kinase (AMPK)\, causing ac
 ute metabolic changes through phosphorylation and prolonged adaptation of 
 metabolism through transcriptional effects. Transcription factor EB (TFEB)
  is a major effector of AMPK that increases expression of lysosome genes i
 n response to energetic stress\, but how AMPK activates TFEB remains unres
 olved. We demonstrate that AMPK directly phosphorylates five conserved ser
 ine residues in folliculin-interacting protein 1 (FNIP1)\, suppressing the
  function of the folliculin (FLCN)-FNIP1 complex. FNIP1 phosphorylation is
  required for AMPK to induce nuclear translocation of TFEB and TFEB-depend
 ent increases of peroxisome proliferator-activated receptor gamma coactiva
 tor 1-alpha (PGC1α) and estrogen-related receptor alpha (ERRα) messenger
  RNAs. Thus\, mitochondrial damage triggers AMPK-FNIP1-dependent nuclear t
 ranslocation of TFEB\, inducing sequential waves of lysosomal and mitochon
 drial biogenesis. \nSpeakers:\nDr Nazma Malik (Salk Institute)
LOCATION:Online - email hod-pa@dpag.ox.ac.uk for the details
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/3f009131-2941-4450-ae59-310395779272/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:AMPK phosphorylation of FNIP1 dictates the kinetics of ly
 sosome and mitochondrial biogenesis - Dr Nazma Malik (Salk Institute)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR