BEGIN:VCALENDAR VERSION:2.0 PRODID:talks.ox.ac.uk BEGIN:VEVENT SUMMARY:Lunchtime Lab Talks: Mentzer & Beagrie Groups - TBC DTSTART;VALUE=DATE-TIME:20260624T123000 DTEND;VALUE=DATE-TIME:20260624T133000 UID:https://talks.ox.ac.uk/talks/id/eb8caf6d-bab6-4307-ab05-a45e2ed637be/ DESCRIPTION:TBC\nSpeakers:\n Various Speakers LOCATION:Rooms A&B or join on MS Teams: https://teams.microsoft.com/l/meet up-join/19%3ameeting_MDgyOTQ0NDMtZTQxYy00YmNhLWI4ZDgtNDJhMDQ3ZWUyZWZh%40th read.v2/0?context=%7b%22Tid%22%3a%22cc95de1b-97f5-4f93-b4ba-fe68b852cf91%2 2%2c%22Oid%22%3a%22faee8eaf-f9bf-478e-9151-5bbfc3b39a0f%22%7d TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/eb8caf6d-bab6-4307-ab05-a45e2ed637be/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Lunchtime Lab Talks: Mentzer & Beagrie Groups - TBC TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Lunchtime Lab Talks: Mentzer & Fowler Groups DTSTART;VALUE=DATE-TIME:20260211T123000Z DTEND;VALUE=DATE-TIME:20260211T133000Z UID:https://talks.ox.ac.uk/talks/id/05596dba-6f36-4269-b1b4-295bb16d2758/ DESCRIPTION:Mentzer Group \nSpeaker(s): TBC\nTitle(s): TBC\n\nFowler Group \nSpeaker(s): Luigi Celauro\, Jack Williams & Sybille Marchese\nTitle: Sub cellular\, spatial 'omics of tauopathies: which tau species to target and where?\n\nSpeakers:\n Various Speakers LOCATION:Wellcome Trust Centre for Human Genetics (Rooms A&B or join on MS Teams: https://teams.microsoft.com/l/meetup-join/19%3ameeting_ZGY5N2MxNGU tMGNlNy00ZGQ0LTlhNDQtY2M2OGQwMDNkOTY3%40thread.v2/0?context=%7b%22Tid%22%3 a%22cc95de1b-97f5-4f93-b4ba-fe68b852cf91%22%2c%22Oid%22%3a%22faee8eaf-f9bf -478e-9151-5bbfc3b39a0f%22%7d)\, Headington OX3 7BN TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/05596dba-6f36-4269-b1b4-295bb16d2758/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Lunchtime Lab Talks: Mentzer & Fowler Groups TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Medical Grand Rounds - Week 2: Infectious Diseases. Theme: Antimi crobial Resistance - Dr Alex Mentzer\, Dr Bernadette Young\, Dr Mehreen Da too\, Dr Charles Woodrow DTSTART;VALUE=DATE-TIME:20240118T130000Z DTEND;VALUE=DATE-TIME:20240118T140000Z UID:https://talks.ox.ac.uk/talks/id/72d92d17-f0cc-4333-8840-18418b6cafa3/ DESCRIPTION:Lesson of the week\, clinical cases and research.\nAll clinica l and academic staff and students welcome.\nCoffee and Tea will be served. \nSpeakers:\nDr Alex Mentzer\, Dr Bernadette Young\, Dr Mehreen Datoo\, Dr Charles Woodrow LOCATION:John Radcliffe Hospital (Lecture Theatre 1\, Academic Street)\, H eadington OX3 9DU TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/72d92d17-f0cc-4333-8840-18418b6cafa3/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Medical Grand Rounds - Week 2: Infectious Diseases. Them e: Antimicrobial Resistance - Dr Alex Mentzer\, Dr Bernadette Young\, Dr M ehreen Datoo\, Dr Charles Woodrow TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Realising the benefit to healthcare through population-wide applic ation of polygenic risk scores - Prof Gil McVean (Genomics PLC) DTSTART;VALUE=DATE-TIME:20230306T093000Z DTEND;VALUE=DATE-TIME:20230306T110000Z UID:https://talks.ox.ac.uk/talks/id/50db5ed8-485f-4fa0-959d-6d5096e6d98d/ DESCRIPTION:\nSpeakers:\nProf Gil McVean (Genomics PLC) LOCATION:Wellcome Trust Centre for Human Genetics (Room A/B)\, Headington OX3 7BN TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/50db5ed8-485f-4fa0-959d-6d5096e6d98d/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Realising the benefit to healthcare through population-wi de application of polygenic risk scores - Prof Gil McVean (Genomics PLC) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Simple scaling laws control the architectures of human complex tra its - Professor Jonathan Pritchard (Stanford University) DTSTART;VALUE=DATE-TIME:20221020T100000 DTEND;VALUE=DATE-TIME:20221020T110000 UID:https://talks.ox.ac.uk/talks/id/1865693c-a1aa-45b1-88f1-4438f39f82e9/ DESCRIPTION:Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely\, including in terms of the n umbers\, effect sizes\, and allele frequencies of significant hits. Howeve r\, at present we lack a principled way of understanding the similarities and differences among traits. In this talk I describe a model that combine s mutation\, drift\, and stabilizing selection at individual sites with a genome-scale model of phenotypic variation. In this model\, the architectu re of a trait arises from the distribution of selection coefficients of mu tations and from two scaling parameters. We fit the model for 95 diverse\, highly polygenic quantitative traits from the UK Biobank. Surprisingly\, we infer similar distributions of selection coefficients across all these traits. This shared distribution implies that differences in architecture s of highly polygenic traits arise mainly from two scaling parameters: the mutational target size and heritability per site\, which vary by orders o f magnitude across traits. When these two scale factors are accounted for\ , the architectures of all 95 traits are nearly identical. This is joint w ork with Yuval Simons\, Hakhamanesh Mostafavi\, Courtney Smith and Guy Sel la.\nSpeakers:\nProfessor Jonathan Pritchard (Stanford University) LOCATION:Richard Doll Building (Richard Doll Lecture Theatre / To join rem otely please put yourself on mute and use the following Teams link: https: //teams.microsoft.com/dl/launcher/launcher.html?url=%2F_%23%2Fl%2Fmeetup-j oin%2F19%3Ameeting_YTU1MTljZDMtNGY1OS00MTAzLTlkYzgtNDA3MzY3YzVmNTVh%40thre ad.v2%2F0%3Fcontext%3D%257b%2522Tid%2522%253a%2522cc95de1b-97f5-4f93-b4ba- fe68b852cf91%2522%252c%2522Oid%2522%253a%2522faee8eaf-f9bf-478e-9151-5bbfc 3b39a0f%2522%257d%26anon%3Dtrue&type=meetup-join&deeplinkId=6a2aea20-754b- 4ba7-b9a8-38977c362952&directDl=true&msLaunch=true&enableMobilePage=true&s uppressPrompt=true)\, Old Road Campus OX3 7LF TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/1865693c-a1aa-45b1-88f1-4438f39f82e9/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Simple scaling laws control the architectures of human co mplex traits - Professor Jonathan Pritchard (Stanford University) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY: Horton Hospital / Rheumatology - Dr Lorraine O’Neill\, Dr Alex Mentzer\, Dr Ian Arnold\, Dr Neil Stewart DTSTART;VALUE=DATE-TIME:20190124T130000Z DTEND;VALUE=DATE-TIME:20190124T140000Z UID:https://talks.ox.ac.uk/talks/id/941537b6-5e9e-46e4-b4dd-ab0c7fa4fa6a/ DESCRIPTION:Horton Hospital: "Stroke: The Heart of the Matter"\, Dr Alex M entzer\, Dr Ian Arnold and Dr Neil Stewart --\nRheumatology: "A Wolf in Sh eep's Clothing"\, Dr Lorraine O’Neill --\nChair: Prof Chris Conlon\nSpea kers:\nDr Lorraine O’Neill\, Dr Alex Mentzer\, Dr Ian Arnold\, Dr Neil S tewart LOCATION:Venue to be announced TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/941537b6-5e9e-46e4-b4dd-ab0c7fa4fa6a/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk: Horton Hospital / Rheumatology - Dr Lorraine O’Neill\, Dr Alex Mentzer\, Dr Ian Arnold\, Dr Neil Stewart TRIGGER:-PT1H END:VALARM END:VEVENT END:VCALENDAR