BEGIN:VCALENDAR VERSION:2.0 PRODID:talks.ox.ac.uk BEGIN:VEVENT SUMMARY:Title TBC DTSTART;VALUE=DATE-TIME:20260529T140000 DTEND;VALUE=DATE-TIME:20260529T150000 UID:https://talks.ox.ac.uk/talks/id/0a5b3325-d6d8-4414-bee3-3ff0849028c9/ DESCRIPTION:\nSpeakers:\nProf Clare Bryant (University of Cambridge) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/0a5b3325-d6d8-4414-bee3-3ff0849028c9/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Title TBC TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:From Blood To Bench: Broad Spectrum Bacterial Vaccine Targets Via Functional Antibody Discovery - Prof Fadil Bidmos (Imperial College\, Lond on) DTSTART;VALUE=DATE-TIME:20251114T130000Z DTEND;VALUE=DATE-TIME:20251114T140000Z UID:https://talks.ox.ac.uk/talks/id/5fcbcb11-cb98-4812-9982-31e26990fca2/ DESCRIPTION:Dr Fadil Bidmos is an MRC Senior (Non-Clinical) Fellow and Ass ociate Professor of Bacterial Vaccinology at Imperial College London. His research focuses on Reverse Vaccinology 2.0 approaches for the discovery o f novel bacterial vaccine antigens\, with a particular emphasis on paediat ric diseases such as bacterial meningitis\, and on antimicrobial-resistant pathogens including Neisseria gonorrhoeae and Klebsiella pneumoniae. He i s also developing complementary vaccine design and delivery platforms\, in cluding early-stage work on protein–glycan conjugation and synthetic-cel l-based delivery systems.\nSpeakers:\nProf Fadil Bidmos (Imperial College\ , London) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/5fcbcb11-cb98-4812-9982-31e26990fca2/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:From Blood To Bench: Broad Spectrum Bacterial Vaccine Tar gets Via Functional Antibody Discovery - Prof Fadil Bidmos (Imperial Colle ge\, London) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Neonatal Stem Cells derived From Umbilical Cord Tissue for Regener ative and Longevity Medicine - Prof Thang Phan (Yong Loo Lin School of Med icine\; National University of Singapore) DTSTART;VALUE=DATE-TIME:20250723T130000 DTEND;VALUE=DATE-TIME:20250723T140000 UID:https://talks.ox.ac.uk/talks/id/539fd584-5aaa-41d4-a603-193038e927d5/ DESCRIPTION:Bringing stem cell therapy research from lab to bedside and ma rket faces many challenges ranging from ethical and religious controversia l\, healthcare regulation\, high standard bio-manufacturing to patient aff ordability or insurance reimbursement. Taking all these points into consid eration\, it appears that stem cells derived from human umbilical cord mem brane tissue namely Cord Lining Epithelial Stem Cells (CL-EpiSC) and Cord Lining Mesenchymal Stem Cells (CLMSC) are the ideal source of stem cells t hat can make translational stem cell therapy happen in reality. Every mont h\, tens of thousands of umbilical cord tissue units are collected and cry opreserved in the US\, EU and Asia together with cord blood for future use as the source of autologous and allogenic stem cell transplant . With reg ards of allogenic stem cell therapy\, freely donated umbilical cord tissue samples are easily and inexpensively collected and qualified in the Color ado Cord Blood Bank. With billions of stem cells isolated from a single co rd membrane tissue at low passages in FDA-licensed GMP Stem Cell Facility in Colorado and Roslin Cell Therapy in Scotland\, the cost of Cord Lining Epithelial Stem Cells (CL-EpiSC) and Cord Lining Mesenchymal Stem Cells (C LMSC) products can be potentially lower and make more affordable to health care receivers.\n \nTranslational stem cell therapy is an expensive game a nd highly capital intensive. To keep it sustainable and make it profitable is another big challenge. Over 30 mins of presentation and discussion\, t he author will share with audience his story to make CellResearch Corp bec ome a most successful stem cell biotech company in Singapore and the regio n.\n \n \nA graduate of the Military Medical University\, Hanoi\, Vietnam in 1991\, Dr Phan has had a strong interest in wound healing since the ear liest days of his medical and scientific career. His interest led him to h ands-on experience during his four-year surgical residency in Hanoi at the National Burns Centre and at the Department of Trauma Surgery\, Military Hospital 103. \n\nDr. Phan's commitment and excellence in laboratory resea rch was proven when he spent two years at the prestigious Wound Healing In stitute and Department of Dermatology in Oxford\, England. \nHe arrived in Singapore in 1997 to join the Department of Plastic Surgery at the Singap ore General Hospital. In 1998\, he met Dr Ivor Lim\, and together they est ablished the Wound Healing and Stem Cell Research Group focusing on skin a nd keloid scar biology. The Wound Healing and Stem Cell Research Group was the first group in the world to explore the role of epithelial-mesenchyma l interactions in keloid pathogenesis and is recognised today as one of th e world leading groups in keloid and scar biology research. \nPrior to tak ing up his faculty position at the Department of Surgery\, Yong Loo Lin Sc hool of Medicine at the National University of Singapore\, Dr. Phan comple ted two years of post-doctoral research at the Stanford University Institu te for Stem Cell Research and Regenerative Medicine\nAs a successful acade mic researcher and entrepreneur\, Dr. Phan is author of more than 80 publi cations in international peer-reviewed journals\, two book chapters\, has more than 80 granted patents and founder of multiple successful biotech an d healthcare companies in Singapore and Vietnam. His recent innovative res earch work is the discovery of a novel source of stem cells from the umbil ical cord lining membrane with translational potential for regenerative me dicine\, tissue engineering and cell-based therapy.\n\nSpeakers:\nProf Tha ng Phan (Yong Loo Lin School of Medicine\; National University of Singapor e) LOCATION:Sir William Dunn School of Pathology (EPA Seminar room )\, South Parks Road OX1 3RE TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/539fd584-5aaa-41d4-a603-193038e927d5/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Neonatal Stem Cells derived From Umbilical Cord Tissue fo r Regenerative and Longevity Medicine - Prof Thang Phan (Yong Loo Lin Scho ol of Medicine\; National University of Singapore) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Pathogenesis of Enterococcus faecalis biofilm-associated infection - Prof Kimberly A. Kline (University of Geneva) DTSTART;VALUE=DATE-TIME:20250523T130000 DTEND;VALUE=DATE-TIME:20250523T140000 UID:https://talks.ox.ac.uk/talks/id/12ed9f40-134c-4345-a8cc-0da93a3ad06b/ DESCRIPTION:Kimberly Kline is a Professor in the Department of Microbiolog y and Molecular Medicine at the University of Geneva in Switzerland. From 2011-2022\, she was a Professor in the School of Biological Sciences at NT U Singapore and a Principal Investigator at SCELSE. Kimberly received a Ma ster’s in Public Health and a PhD in Microbiology and Immunology from No rthwestern University where she studied Type IV pilus antigenic variation in Neisseria gonorrhoeae. She completed postdoctoral training at Washingto n University in St. Louis and at the Karolinska Institute in Stockholm Swe den where she began investigating the pathogenic mechanisms of Enterococcu s faecalis. Kimberly has received multiple awards for her contributions to the field of microbiology\, including a NIH K99 Career Development Award in 2011\, the Singapore National Research Foundation Fellowship in 2011\, the ICAAC Young Investigator Award from the American Society of Microbiolo gy in 2014\, the Nanyang Education Award in 2017\, and election to the Ame rican Academy of Microbiology in 2025. Current research interests of her g roup include the pathogenic mechanisms of polymicrobial biofilm-associated infections\, including catheter-associated urinary tract infections\, wou nd infections\, and infective endocarditis. Given the intrinsic phenotypic resistance of biofilms to antimicrobials\, her team seeks to exploit thei r fundamental discoveries to identify new therapeutic intervention points for these difficult-to-treat infections.\nSpeakers:\nProf Kimberly A. Klin e (University of Geneva) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/12ed9f40-134c-4345-a8cc-0da93a3ad06b/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Pathogenesis of Enterococcus faecalis biofilm-associated infection - Prof Kimberly A. Kline (University of Geneva) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Eco-evolutionary design rules for phage therapy - Prof Michael Bro ckhurst (University of Manchester) DTSTART;VALUE=DATE-TIME:20241009T110000 DTEND;VALUE=DATE-TIME:20241009T120000 UID:https://talks.ox.ac.uk/talks/id/aaa1c979-df93-4573-9df5-3b5359597786/ DESCRIPTION:\nSpeakers:\nProf Michael Brockhurst (University of Manchester ) LOCATION:Sir William Dunn School of Pathology (EPA Seminar Room)\, South P arks Road OX1 3RE TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/aaa1c979-df93-4573-9df5-3b5359597786/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Eco-evolutionary design rules for phage therapy - Prof Mi chael Brockhurst (University of Manchester) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:From dendritic cells to inflammatory bowel disease - Prof Simon Mi lling (University of Glasgow) DTSTART;VALUE=DATE-TIME:20240913T140000 DTEND;VALUE=DATE-TIME:20240913T150000 UID:https://talks.ox.ac.uk/talks/id/1e07e721-ed5f-42e1-a81b-d310e6f7c2dc/ DESCRIPTION:Simon Milling is a Professor of Immunology and Deputy Head of the Centre for Immunobiology at the School of Infection & Immunity at the University of Glasgow. He received his PhD from Imperial College London\, where he studied antigen presentation to human T cell clones under Profes sor Robert Lechler and Dr Sara Brett. He then worked as a postdoctoral res earcher in Philadelphia and Oxford before joining the University of Glasgo w as a lecturer in 2007. He became a professor at the university in 2017 a nd became the Deputy Head of Immunology in 2020. \nHis research focuses on the biology of antigen-presenting cells in the intestine and skin\, and o n how these cells respond to infectious or inflammatory stimuli. He has a translational focus on inflammatory bowel disease\, spondyloarthropathies\ , and autoimmune alopecia The aim of this work is to understand the vital roles that antigen-presenting cells play\, both in the induction and polar isation of adaptive immune responses against pathogens and in the patholog y of inflammatory and autoimmune diseases\nSpeakers:\nProf Simon Milling ( University of Glasgow) LOCATION:EPA Seminar room TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/1e07e721-ed5f-42e1-a81b-d310e6f7c2dc/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:From dendritic cells to inflammatory bowel disease - Prof Simon Milling (University of Glasgow) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:The Type VI secretion system of Serratia marcescens and bacterial arms races - Prof Sarah Coulthurst (University of Dundee) DTSTART;VALUE=DATE-TIME:20240510T130000 DTEND;VALUE=DATE-TIME:20240510T140000 UID:https://talks.ox.ac.uk/talks/id/c879f413-0b92-45cb-8554-0f0592c29672/ DESCRIPTION:Sarah is a Wellcome Senior Research Fellow and Professor of Mi crobial interactions based in the School of Life Sciences at the Universit y of Dundee. She is a molecular bacteriologist with long-standing interest s in protein secretion systems and inter-bacterial interactions\, both co- operative and competitive. Following PhD and postdoctoral work in the labs of George Salmond in Cambridge and Frank Sargent in Dundee\, Sarah establ ished her own group in 2009. Work in her lab is mainly focused on the Type VI secretion system\, a protein ‘nanoweapon’ used by many bacteria to deliver toxic effector proteins into neighbouring cells. Her group aim to understand how the Type VI secretion system effectively delivers effector s into bacterial and fungal competitors\, to determine the mode of action of the effectors\, and to understand the impact of the system and its secr eted effectors on targeted cells\, populations and communities. Sarah’s contributions have been recognised by the Microbiology Society Fleming Pri ze\, the SfAM W.H. Pierce Prize\, and the Royal Society of Edinburgh Patri ck Neill Medal.\nSpeakers:\nProf Sarah Coulthurst (University of Dundee) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/c879f413-0b92-45cb-8554-0f0592c29672/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The Type VI secretion system of Serratia marcescens and b acterial arms races - Prof Sarah Coulthurst (University of Dundee) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Transcriptomics in infectious diseases- Biomarkers & Biology - Pro f Mahdad Noursadeghi (UCL) DTSTART;VALUE=DATE-TIME:20231103T140000Z DTEND;VALUE=DATE-TIME:20231103T150000Z UID:https://talks.ox.ac.uk/talks/id/48f17764-ad5b-4ecd-ac06-4730a1e0d7f5/ DESCRIPTION:\nSpeakers:\nProf Mahdad Noursadeghi (UCL) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/48f17764-ad5b-4ecd-ac06-4730a1e0d7f5/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Transcriptomics in infectious diseases- Biomarkers & Biol ogy - Prof Mahdad Noursadeghi (UCL) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Transposons: from molecular mechanisms to the clinic - Prof David Grainger (University of Birmingham) DTSTART;VALUE=DATE-TIME:20230929T140000 DTEND;VALUE=DATE-TIME:20230929T150000 UID:https://talks.ox.ac.uk/talks/id/0232a1ea-e37c-4410-919e-1b2e224bf108/ DESCRIPTION:My work has focused on understanding how bacteria organise the ir genetic material and regulate its expression. As a post-graduate studen t\, in Steve Busby’s lab at the University of Birmingham\, I studied gen e regulation in E. coli. This work was very focused on individual chromoso mal loci. My post-doctoral work took a different direction using genome-sc ale approaches. In 2008\, I started my laboratory at the University of War wick. Rather than focusing on gene regulation\, I moved more towards the s tudy of chromosome folding. My group moved back to Birmingham in 2012 and our research expanded into different organisms\, particularly human pathog ens. Most recently\, we have started a new focus on Acinetobacter baumanni i\, the WHO’s pathogen of most concern. We have identified transposons a s a key source of phenotypic heterogeneity in A. baumannii populations. We are starting to understand the clinical relevance and underlying molecula r mechanisms\nSpeakers:\nProf David Grainger (University of Birmingham) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/0232a1ea-e37c-4410-919e-1b2e224bf108/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Transposons: from molecular mechanisms to the clinic - Pr of David Grainger (University of Birmingham) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Redefining mobility in bacterial genetics and its impact on infect ious disease - Prof Jose Penades (Imperial College\, London) DTSTART;VALUE=DATE-TIME:20230602T140000 DTEND;VALUE=DATE-TIME:20230602T150000 UID:https://talks.ox.ac.uk/talks/id/42b4ad95-328f-4ab7-8097-f02302ad19a7/ DESCRIPTION:José R Penadés is Professor of Microbiology and Director Cen tre for bacterial Resistance Biology\, at Imperial College London. Researc h in Penadés lab has focused for the last two decades into the molecular basis of bacterial virulence\, using Staphylococcus aureus as a model\, wi th a major focus on the mechanisms underlying the transfer of different mo bile genetic elements involved in pathogenesis.\nProfessor Penadés work h as redefined the concept of mobility in bacterial genetics. He discovered the most powerful mode of phage transduction described to date: lateral tr ansduction. He demonstrated that via lateral transduction\, the mobility o f the bacterial chromosomes exceeds that of elements classically considere d to be mobile\, forcing a re-definition of what a mobile genetic element is. He has also discovered and characterised the mechanism of transfer of a widespread and clinically important family of mobile genetic elements\, the Phage-Inducible Chromosomal Islands. \n Prof. Penadés is Member of th e European Academy of Microbiology and an EMBO member\, as well as a Fello w of the Royal Society of Edinburgh.\n\nSpeakers:\nProf Jose Penades (Impe rial College\, London) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/42b4ad95-328f-4ab7-8097-f02302ad19a7/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Redefining mobility in bacterial genetics and its impact on infectious disease - Prof Jose Penades (Imperial College\, London) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Overriding MHC class I antigen presentation - Prof Louise Boyle (U niversity of Cambridge) DTSTART;VALUE=DATE-TIME:20221007T140000 DTEND;VALUE=DATE-TIME:20221007T150000 UID:https://talks.ox.ac.uk/talks/id/3373ac84-0d86-4d8b-b9bb-ef0c41e37636/ DESCRIPTION:Louise Boyle is Professor of Molecular Immunology and a Wellco me Trust Senior Research Fellow at the Department of Pathology\, Universit y of Cambridge. Her research focuses on molecular pathways controlling ant igen presentation to the immune system. Work in the Boyle lab focuses on a dvancing knowledge of peptide selection by Major Histocompatibility (MHC) molecules - vital research given the critical role that these molecules pl ay in infection control and the recognition of cancer. Louise made the ke y discovery that TAPBPR plays a role in the MHC I antigen processing and p resentation pathway and her laboratory was at the forefront of characteris ing the function of TAPBPR. The discoveries made through this research hav e provided novel insights into MHC biology and identified translational op portunities to increase the immunogenicity of cells which may pave the way for new therapeutics.\nSpeakers:\nProf Louise Boyle (University of Cambri dge) LOCATION:Medical Sciences Teaching Centre\, off South Parks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/3373ac84-0d86-4d8b-b9bb-ef0c41e37636/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Overriding MHC class I antigen presentation - Prof Louise Boyle (University of Cambridge) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:The ties that bond: Unmasking the biofilm potential of the gut sym biont Bacteroides thetaiotaomicron - Prof Jean-Marc Ghigo (Institut Pasteu r\, Paris) DTSTART;VALUE=DATE-TIME:20220610T140000 DTEND;VALUE=DATE-TIME:20220610T150000 UID:https://talks.ox.ac.uk/talks/id/66f394e4-a554-4459-8768-f44b82d1a36c/ DESCRIPTION:\nSpeakers:\nProf Jean-Marc Ghigo (Institut Pasteur\, Paris) LOCATION:Medical Sciences Teaching Centre\, off South Parks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/66f394e4-a554-4459-8768-f44b82d1a36c/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The ties that bond: Unmasking the biofilm potential of th e gut symbiont Bacteroides thetaiotaomicron - Prof Jean-Marc Ghigo (Instit ut Pasteur\, Paris) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:The evolutionary ecology of host defence and counter-defence - Pro f Edze Westra (University of Exeter) DTSTART;VALUE=DATE-TIME:20211008T140000 DTEND;VALUE=DATE-TIME:20211008T150000 UID:https://talks.ox.ac.uk/talks/id/0ac25164-3f3a-4332-bdb0-f4ec3db91492/ DESCRIPTION:Organisms can evolve different defences in response to pathoge n infection. My lab studies the interactions between bacteria and their vi ruses (bacteriophage\, phage) to understand how environmental variables dr ive the evolution of different defence strategies. The bacteria that we st udy\, Pseudomonas aeruginosa\, is an important opportunistic human pathoge n that a number of different defence strategies to protect itself against phage infection\, including an adaptive immune system (known as CRISPR-Cas ) and various innate defences (e.g. phage receptor mutation). I will discu ss how and why certain environmental variables tip the balance in the evol ution of these defences and their long-term evolutionary and coevolutionar y consequences. I will also discuss how being able to predict and manipula te the evolution of phage resistance can help to optimize the therapeutic application of phage. \n\nWestra performed his PhD at Wageningen Univers ity\, the Netherlands\, on the mechanism and regulation of CRISPR-Cas immu ne systems. Following his PhD (2013\, awarded with distinction) he obtaine d a Marie Curie Fellowship and a NERC Independent Research Fellowship to s tudy evolutionary aspects of CRISPR-phage interactions at the University o f Exeter\, where he was offered a chair in 2019. Westra received a number of prestigious awards for his work\, including the Heineken Young Scientis ts Award\, the Fleming Award and the Philip Leverhulme Prize\, and he was finalist for the Blavatnik Young Scientist Awards in 2020 and 2021. His re search group currently consists of 4 PhD students and 5 postdocs who study various aspects of the ecology and evolution of phage-bacteria interactio ns. His research is funded by NERC\, BBSRC\, Wellcome and Leverhulme Trust s and the ERC. Westra is Director of Research of Biosciences at the Penryn campus\, and leads the University of Exeter Microbiology Network\, the Mi crobes and Society Network\, and is the lead organizer of the biannual CRI SPR ecology and evolution conference\nSpeakers:\nProf Edze Westra (Univers ity of Exeter) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/0ac25164-3f3a-4332-bdb0-f4ec3db91492/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The evolutionary ecology of host defence and counter-defe nce - Prof Edze Westra (University of Exeter) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:How has Salmonella become so dangerous in Africa? - Prof Jay Hinto n (University of Liverpool) DTSTART;VALUE=DATE-TIME:20210604T140000 DTEND;VALUE=DATE-TIME:20210604T150000 UID:https://talks.ox.ac.uk/talks/id/46c5880b-5fa1-4df0-9a75-3ba2a9b6ab48/ DESCRIPTION:Jay Hinton is the Professor of Microbial Pathogenesis at the U niversity of Liverpool\, UK. He did his first degree in Microbiology\, whe n he was inspired to think genetically by Prof. George Salmond. After his PhD\, he moved to the University of Oxford to work on the regulation of v irulence gene expression in Salmonella\, and subsequently moved to Norwich \, UK\, as Head of Molecular Microbiology at the Institute of Food Researc h.\nHe has been fascinated by bacterial functional genomics for the past 2 0 years. In 2003\, he pioneered a transcriptomic approach that revealed a "snapshot" of Salmonella gene expression during the process of infection o f mammalian cells\, and co-discovered the H-NS-mediated mechanism of silen cing gene expression in bacteria in 2006.\nJay moved to Liverpool in 2012 to refocus his lab on the lethal epidemic of bloodstream infections caused by Salmonella in sub-Saharan Africa. His team is now using a combination of molecular microbiology\, genomics and functional transcriptomics to gen erate new insights. Recent discoveries include the determination of the ro le of a single noncoding nucleotide in the over-expression of a key virule nce factor in African Salmonella (Hammarlöf et al\, PNAS) and an understa nding of the step-wise evolution of African Salmonella (Pulford et al\, Na ture Microbiology).\nJay was elected to membership of the European Academy of Microbiology in 2018.\n\nSpeakers:\nProf Jay Hinton (University of Liv erpool) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/46c5880b-5fa1-4df0-9a75-3ba2a9b6ab48/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:How has Salmonella become so dangerous in Africa? - Prof Jay Hinton (University of Liverpool) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Deconstructing a T3SS effector network unravels the inherent robus tness and plasticity in pathogenesis and immunity - Prof Gad Frankel (Impe rial College\, London) DTSTART;VALUE=DATE-TIME:20210507T140000 DTEND;VALUE=DATE-TIME:20210507T150000 UID:https://talks.ox.ac.uk/talks/id/7c4173d3-7448-46bf-9236-9db3bd09b40c/ DESCRIPTION:\nSpeakers:\nProf Gad Frankel (Imperial College\, London) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/7c4173d3-7448-46bf-9236-9db3bd09b40c/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Deconstructing a T3SS effector network unravels the inher ent robustness and plasticity in pathogenesis and immunity - Prof Gad Fran kel (Imperial College\, London) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Informing shigellosis control and management in resource poor sett ings through pathogen genomics - Dr Kate Baker (University of Liverpool) DTSTART;VALUE=DATE-TIME:20210202T140000Z DTEND;VALUE=DATE-TIME:20210202T150000Z UID:https://talks.ox.ac.uk/talks/id/2cbcccab-9d99-4d19-b29f-f10a456f3f82/ DESCRIPTION:The Global Enteric Multicentre Study (GEMS) was a case-control study that identified Shigella as a leading causes of moderate-to-severe diarrhoea in children under the age of 5 years old in sub-Saharan Africa a nd Asia\, yet Shigella is increasingly resistant to antimicrobials\, and t here is no licensed vaccine. Here\, we performed large-scale analysis of a pproximately 1500 Shigella from GEMS to determine the genomic and genetic diversity among this relevant\, systematically obtained isolate collection to draw out implications for management of the disease with antimicrobial s as well as prevention through vaccination. We find differences among the diversity between Shigella species and collection sites\, including varia tion in the epitope region of protein antigen vaccine targets and serotype switching events that will affect glycoconjugate vaccination approaches. We also identify significant differences between species and site with reg ard to the development of antimicrobial resistance and\, finally\, in cond ucting a pathogen genome-wide-association-study\, we identify pathogen gen etic factors that contribute to the elaboration of shigellosis. Thus\, who le genome sequence analysis of this representative dataset has provided a new lens through which to view the diversity of these pathogens in those p opulations most vulnerable to severe disease and highlighted several signi ficant hurdles we may face in continued management of the disease through antimicrobials and in implementing future vaccination programs\nSpeakers:\ nDr Kate Baker (University of Liverpool) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/2cbcccab-9d99-4d19-b29f-f10a456f3f82/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Informing shigellosis control and management in resource poor settings through pathogen genomics - Dr Kate Baker (University of Li verpool) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Lung epithelia under attack: Infection\, Interferon\, Inflammation - Dr Andreas Wack (The Francis Crick Institute\, London) DTSTART;VALUE=DATE-TIME:20210319T140000Z DTEND;VALUE=DATE-TIME:20210319T150000Z UID:https://talks.ox.ac.uk/talks/id/633daec1-435d-4f7d-8ab4-e3b8d4477b29/ DESCRIPTION:\nSpeakers:\nDr Andreas Wack (The Francis Crick Institute\, Lo ndon) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/633daec1-435d-4f7d-8ab4-e3b8d4477b29/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Lung epithelia under attack: Infection\, Interferon\, Inf lammation - Dr Andreas Wack (The Francis Crick Institute\, London) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:E. coli persistence to ofloxacin - Prof Laurence Van Melderen (Uni versité Libre de Bruxelles\, Belgium) DTSTART;VALUE=DATE-TIME:20210305T140000Z DTEND;VALUE=DATE-TIME:20210305T150000Z UID:https://talks.ox.ac.uk/talks/id/df37300f-2855-4692-95f9-19c7931a2046/ DESCRIPTION:\nSpeakers:\nProf Laurence Van Melderen (Université Libre de Bruxelles\, Belgium) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/df37300f-2855-4692-95f9-19c7931a2046/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:E. coli persistence to ofloxacin - Prof Laurence Van Meld eren (Université Libre de Bruxelles\, Belgium) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Pathoecology and evolution of Vibrio cholerae - Prof Melanie Bloke sch (EPFL (Lausanne)\, Switzerland) DTSTART;VALUE=DATE-TIME:20210129T140000Z DTEND;VALUE=DATE-TIME:20210129T150000Z UID:https://talks.ox.ac.uk/talks/id/1c9be501-3553-42c8-8a78-204f553994b3/ DESCRIPTION:\nSpeakers:\nProf Melanie Blokesch (EPFL (Lausanne)\, Switzerl and) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/1c9be501-3553-42c8-8a78-204f553994b3/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Pathoecology and evolution of Vibrio cholerae - Prof Mela nie Blokesch (EPFL (Lausanne)\, Switzerland) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Single-cell physiology of bacterial pathogens in rodent and human host tissues - Prof Dirk Baumann (Biozentrum\, University of Basel\, Switz erland) DTSTART;VALUE=DATE-TIME:20201113T130000Z DTEND;VALUE=DATE-TIME:20201113T140000Z UID:https://talks.ox.ac.uk/talks/id/85c6bd5a-450e-4da2-a508-6658d5efda59/ DESCRIPTION:\nSpeakers:\nProf Dirk Baumann (Biozentrum\, University of Bas el\, Switzerland) LOCATION:Via Zoom TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/85c6bd5a-450e-4da2-a508-6658d5efda59/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Single-cell physiology of bacterial pathogens in rodent a nd human host tissues - Prof Dirk Baumann (Biozentrum\, University of Base l\, Switzerland) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Structural studies of microbial self-defence mechanisms - Dr Ditl ev Brodersen (Associate Professor\, Department of Molecular Biology and Ge netics\, Aarhus University\, Denmark) DTSTART;VALUE=DATE-TIME:20180607T100000 DTEND;VALUE=DATE-TIME:20180607T110000 UID:https://talks.ox.ac.uk/talks/id/6147fe0c-7371-48db-affa-b804875d1423/ DESCRIPTION:\nSpeakers:\nDr Ditlev Brodersen (Associate Professor\, Depart ment of Molecular Biology and Genetics\, Aarhus University\, Denmark) LOCATION:Sir William Dunn School of Pathology (EPA Seminar Room)\, South P arks Road OX1 3RE TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/6147fe0c-7371-48db-affa-b804875d1423/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Structural studies of microbial self-defence mechanisms - Dr Ditlev Brodersen (Associate Professor\, Department of Molecular Biolo gy and Genetics\, Aarhus University\, Denmark) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Global reprogramming of the Yersinia pseudotuberculosis transcript ional landscape in response to host signals - Professor Petra Dersch (Helm holtz Centre for Infection Research) DTSTART;VALUE=DATE-TIME:20171103T140000Z DTEND;VALUE=DATE-TIME:20171103T150000Z UID:https://talks.ox.ac.uk/talks/id/64b9c42c-74e7-4aac-8e0d-c908db757a1d/ DESCRIPTION:\nSpeakers:\nProfessor Petra Dersch (Helmholtz Centre for Infe ction Research) LOCATION:Medical Sciences Teaching Centre (Lecture Theatre)\, off South Pa rks Road OX1 3PL TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/64b9c42c-74e7-4aac-8e0d-c908db757a1d/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Global reprogramming of the Yersinia pseudotuberculosis t ranscriptional landscape in response to host signals - Professor Petra Der sch (Helmholtz Centre for Infection Research) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:The Penicillin case. The history of antibiosis before and after Lo rd Florey - Dr Giovanni Savignano (G. Moscati Hospital\, Avellino\, Italy) DTSTART;VALUE=DATE-TIME:20160503T110000 DTEND;VALUE=DATE-TIME:20160503T120000 UID:https://talks.ox.ac.uk/talks/id/1571e9e3-1d33-4f2a-82d3-a2ad50801284/ DESCRIPTION:\nSpeakers:\nDr Giovanni Savignano (G. Moscati Hospital\, Avel lino\, Italy) LOCATION:Sir William Dunn School of Pathology (EPA Seminar Room)\, South P arks Road OX1 3RE TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/1571e9e3-1d33-4f2a-82d3-a2ad50801284/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The Penicillin case. The history of antibiosis before and after Lord Florey - Dr Giovanni Savignano (G. Moscati Hospital\, Avellino \, Italy) TRIGGER:-PT1H END:VALARM END:VEVENT END:VCALENDAR