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SUMMARY:Mass Spectrometry-based Omics Technology in Life Science and Bioma
 rker Driven Transnational Medical Research - Professor Catherine CL Wong\,
  黄超兰 (Chinese Academy of Medical Sciences)
DTSTART;VALUE=DATE-TIME:20230713T140000
DTEND;VALUE=DATE-TIME:20230713T150000
UID:https://talks.ox.ac.uk/talks/id/0d0f5fdd-0224-4732-8bf3-d94a6b2c3ba0/
DESCRIPTION:The field of mass spectrometry has come a long way since its i
 nception in the late 1890s by particle physicists. Through continuous inno
 vation over the last century\, it has evolved into a unique technology. Af
 ter the two ionization technologies\, ESI and MALDI\, were awarded the Nob
 el Prize in 2002\, mass spectrometry moved beyond its traditional role in 
 physical chemistry to become a key technology in the biological sciences. 
 \n\nThe complexity of living organisms and the broad scope of modern biolo
 gy provide ample opportunities for technological innovation in the field o
 f mass spectrometry. Consequently\, mass spectrometry is playing an increa
 singly important role in the discovery of new biological findings\, diseas
 e biomarkers\, and mechanisms of complex diseases. \n\nOur research focuse
 s on developing cutting-edge high-throughput multi-omics technologies\, su
 ch as single-cell proteomics\, absolute quantitative proteomics\, glycomic
 s\, and more\, with the goal of addressing important fundamental biologica
 l questions and unmet clinical needs. \n\nBy exploring and revealing the u
 nknowns in biomedical and clinical research\, we aim to establish standard
 ized procedures for the development and validation of clinical biomarkers\
 , with the aim of contributing to human health.\n\nSpeakers:\nProfessor Ca
 therine CL Wong\, 黄超兰 (Chinese Academy of Medical Sciences)
LOCATION:NDM Building (NDMRB Building Basement Seminar Room)\, Headington 
 OX3 7FZ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/0d0f5fdd-0224-4732-8bf3-d94a6b2c3ba0/
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DESCRIPTION:Talk:Mass Spectrometry-based Omics Technology in Life Science 
 and Biomarker Driven Transnational Medical Research - Professor Catherine 
 CL Wong\, 黄超兰 (Chinese Academy of Medical Sciences)
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SUMMARY:Biological roles of hematopoietic niches in the origination and de
 velopment of leukemia - Professor Dengli Hong (Shanghai Jiao Tong Universi
 ty School of Medicine)
DTSTART;VALUE=DATE-TIME:20230803T120000
DTEND;VALUE=DATE-TIME:20230803T130000
UID:https://talks.ox.ac.uk/talks/id/cf365189-de83-48ef-9aff-c58d8c489702/
DESCRIPTION:My group studies biological roles of hematopoietic niches in t
 he origination and development of leukaemia\, making effort to address two
  issues of pathogenesis and therapeutics of the disease. First\, how devel
 opmental tissue microenvironments provide genome protection for hematopoie
 tic \n tem and progenitor cells (HSPCs) and how the native lack or patholo
 gical loss of protection results in NDA damage and genome instability in H
 SPCs when encountering endogenous\, e.g. metabolic\, or exogenous genotoxi
 c agents and leukaemia initiation. Second\, how leukaemic microenvironment
 s provide protective niches for leukaemic propagating cells in evading the
 rapy including chemotherapy and immunotherapy. The aims of these studies a
 re to identify and characterise the niche cells and molecules that are inv
 olved in leukaemia initiation and development and that can be targeted for
  disease prevention and future therapies. We have recently identified a le
 ukaemogenic niche in the foetal liver and several therapyinduced niches in
  the leukaemic bone marrow. In the seminar talk I will share these interes
 ting findings. \nSpeakers:\nProfessor Dengli Hong (Shanghai Jiao Tong Univ
 ersity School of Medicine)
LOCATION:MRC Weatherall Institute of Molecular Medicine (Seminar Room)\, H
 eadington OX3 9DS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/cf365189-de83-48ef-9aff-c58d8c489702/
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DESCRIPTION:Talk:Biological roles of hematopoietic niches in the originati
 on and development of leukemia - Professor Dengli Hong (Shanghai Jiao Tong
  University School of Medicine)
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SUMMARY:Characterising an unconventional integrin (CD61/CD103) on human ca
 ncer T cell immunity - Tao Dong (University of Oxford)
DTSTART;VALUE=DATE-TIME:20230616T091500
DTEND;VALUE=DATE-TIME:20230616T101500
UID:https://talks.ox.ac.uk/talks/id/4c717ee7-9a91-488a-968f-0d85fdd24e45/
DESCRIPTION:\nSpeakers:\nTao Dong (University of Oxford)
LOCATION:MRC Weatherall Institute of Molecular Medicine (Seminar Room)\, H
 eadington OX3 9DS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/4c717ee7-9a91-488a-968f-0d85fdd24e45/
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ACTION:display
DESCRIPTION:Talk:Characterising an unconventional integrin (CD61/CD103) on
  human cancer T cell immunity - Tao Dong (University of Oxford)
TRIGGER:-PT1H
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