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SUMMARY:Sub-second dopamine and serotonin signalling in human striatum dur
 ing perceptual decision-making - Dan Bang (University College London)
DTSTART;VALUE=DATE-TIME:20210209T130000Z
DTEND;VALUE=DATE-TIME:20210209T140000Z
UID:https://talks.ox.ac.uk/talks/id/f3284918-4532-4069-9fbd-5d23eea2aa54/
DESCRIPTION:Recent animal research indicates that dopamine and serotonin\,
  neuromodulators traditionally associated with appetitive and aversive pro
 cesses\, are also involved in sensory inference and decisions based on suc
 h inference. In this talk\, I will present a study in which we tested this
  hypothesis in the human brain. We used fast-scan cyclic voltammetry adapt
 ed for use during DBS surgery to monitor sub-second changes in striatal do
 pamine and serotonin while patients performed a visual perceptual decision
  task that separates sensory uncertainty from decision difficulty in a fac
 torial design. Caudate nucleus recordings (n=4) revealed multi-scale encod
 ing: in three patients\, serotonin tracked sensory uncertainty\, and\, in 
 one patient\, both dopamine and serotonin tracked deviations from expected
  trial transitions within our factorial design. Putamen recordings (n=1) s
 upported a cognition-action separation between caudate nucleus and putamen
  – a striatal sub-division unique to primates – with both dopamine and
  serotonin tracking decision times. I will argue that these first-of-their
 -kind observations in the human brain support a role for sub-second dopami
 ne and serotonin signalling in non-reward-based aspects of cognition and a
 ction.\nSpeakers:\nDan Bang (University College London)
LOCATION:Venue to be announced
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f3284918-4532-4069-9fbd-5d23eea2aa54/
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DESCRIPTION:Talk:Sub-second dopamine and serotonin signalling in human str
 iatum during perceptual decision-making - Dan Bang (University College Lon
 don)
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