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SUMMARY:Cortical and striatal circuit dynamics during natural and learned 
 actions - Andreas Klaus (Champalimaud\, Portugal)
DTSTART;VALUE=DATE-TIME:20201124T130000Z
DTEND;VALUE=DATE-TIME:20201124T140000Z
UID:https://talks.ox.ac.uk/talks/id/c47443f1-850e-488a-aed9-c39ea6bd3a17/
DESCRIPTION:The striatum is required for action selection and initiation\,
  and regulates behavior via the striatonigral (direct) and striatopallidal
  (indirect) pathways. Both pathways are driven by cortical inputs and incr
 ease their activity at movement onset during natural and learned behaviors
 . Some models of striatal function propose that the direct pathway promote
 s specific actions (i.e.\, action facilitation) whereas the indirect pathw
 ay simultaneously suppresses conflicting actions (i.e.\, action suppressio
 n). However\, we previously found that both striatal pathways are rather a
 ction-specific during natural behaviors. Here\, we show that this striatal
  organization is in fact inherited from the cortex. Furthermore\, to prope
 rly distinguish action facilitation from action suppression\, we developed
  a probabilistic three-alternative choice task and recorded direct- and in
 direct-pathway neurons of the dorsolateral striatum and their motor cortex
  inputs in freely moving mice using intracellular calcium imaging of large
  neuronal populations. We found that activity in the motor cortex increase
 s strongly before trial initiation and remains high until the choice was r
 eported. In contrast\, striatal activity in both pathways was highest when
  mice reported their choice. Thus\, choice information appeared first in t
 he cortex. Importantly\, striatal direct- and indirect-pathway ensembles a
 s well as motor cortex ensembles showed high specificity with regard to th
 e chosen action. This result is not consistent with models that propose an
  action-suppressing function for striatal indirect-pathway neurons. In thi
 s seminar\, I will discuss alternative models of cortico-striatal function
  that we are currently testing using optogenetic inhibition of the motor c
 ortex and the dorsolateral striatum during this task.\nSpeakers:\nAndreas 
 Klaus (Champalimaud\, Portugal)
LOCATION:Venue to be announced
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/c47443f1-850e-488a-aed9-c39ea6bd3a17/
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DESCRIPTION:Talk:Cortical and striatal circuit dynamics during natural and
  learned actions - Andreas Klaus (Champalimaud\, Portugal)
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