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SUMMARY:BEACON Seminar: Circuit-based strategies for long-lasting motor re
 covery following dopamine depletion  - Aryn Gittis (Carnegie Mellon)
DTSTART;VALUE=DATE-TIME:20211130T130000Z
DTEND;VALUE=DATE-TIME:20211130T140000Z
UID:https://talks.ox.ac.uk/talks/id/66f8f3eb-6f23-4692-9634-e8c38a0614a8/
DESCRIPTION:Seminars this term will be held remotely on Zoom. Links for jo
 ining will be sent out before each seminar. Please contact the host if you
  would like to set up a remote meeting with a speaker. If you have suggest
 ions for future speakers\, please contact Lauren (lauren.burgeno@dpag.ox.a
 c.uk)\, or Nima (nima.khalighinejad@psy.ox.ac.uk).\n\nABSTRACT:\nIdentific
 ation of distinct neuronal subpopulations has been essential for understan
 ding brain function\, but clinical applications struggle to access specifi
 c neurons in heterogeneously mingled populations. Recently\, optogenetic p
 rotocols targeting neuronal subpopulations in the external globus pallidus
  (GPe) were shown to provide long-lasting therapeutic effects in dopamine 
 depleted mice.\n\nHere\, we leverage underlying synaptic differences betwe
 en Parvalbumin (PV) and Lim homeobox 6 (Lhx6) subpopulations to drive popu
 lation-specific neuromodulation in the GPe\, using brief bursts of electri
 cal stimulation. We then apply these findings to strategically design a cl
 inically appropriate deep brain stimulation (DBS) protocol\, which we show
  induces long-lasting therapeutic effects that far exceed those of convent
 ional DBS\, extending for hours beyond stimulation. These results establis
 h the feasibility of transforming knowledge about circuit architecture int
 o quickly translatable therapeutic approaches.\n\nRecent Publication relat
 ed to this talk:  https://www.science.org/doi/10.1126/science.abi7852\nSpe
 akers:\nAryn Gittis (Carnegie Mellon)
LOCATION:Venue to be announced
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/66f8f3eb-6f23-4692-9634-e8c38a0614a8/
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DESCRIPTION:Talk:BEACON Seminar: Circuit-based strategies for long-lasting
  motor recovery following dopamine depletion  - Aryn Gittis (Carnegie Mell
 on)
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