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SUMMARY:Nuclear Actin and Links to Splicing and the Nucleolar Stress Respo
 nse - Dr Amanda Coutts (Nottingham Trent University)
DTSTART;VALUE=DATE-TIME:20251201T120000Z
DTEND;VALUE=DATE-TIME:20251201T130000Z
UID:https://talks.ox.ac.uk/talks/id/faf37a0d-a6ac-4b97-b2fc-d340d3f9666a/
DESCRIPTION:Dr Amanda Coutts - Senior Lecturer in Molecular Biosciences an
 d Group Leader: Cancer cell survival and stress response.\n\nAfter obtaini
 ng a PhD in Molecular Biology and Biochemistry (University of Manitoba)\, 
 Amanda undertook postdoctoral studies at the Beatson Institute for Cancer 
 Research\, University of Glasgow\, Dept of Biochemistry\, and the Universi
 ty of Oxford\, Dept of Oncology\, before joining Nottingham Trent Universi
 ty as a Senior Lecturer. At NTU she established her first independent rese
 arch group (John van Geest Cancer Research Centre (JvGCRC)\, SHiMR researc
 h Centre) where her research focuses on understanding how cancer cell surv
 ival pathways link to disease progression and how stress responses influen
 ce nuclear structure and function.\n\nMechanisms influencing cell survival
  such as apoptosis and autophagy are key determinants of cell fate during 
 stress. Importantly\, understanding how the cell integrates a variety of s
 ignals to affect a cellular outcome is clinically relevant and a poorly un
 derstood process. My work involving the p53 co-factor JMY has uncovered no
 vel links between cell motility and the DNA damage response as well as mec
 hanisms involved in autophagy and cell survival\, and particularly\, the r
 ole of actin in these processes. During this seminar I will discuss some r
 ecent research that has uncovered novel links with splicing regulators and
  nuclear actin. While evidence supports an important functional role of nu
 clear actin in processes fundamental to gene expression and cellular pheno
 type\, the molecular details and key players are underexplored. We have re
 cently identified nuclear filamentous (F)-actin formation in response to s
 pecific modulators of pre-mRNA splicing. Moreover\, this has uncovered lin
 ks with nuclear F-actin and the nucleolar stress response – thus suggest
 ing that under certain conditions the formation of nuclear F-actin trigger
 s a unique stress response that impacts cancer cell survival. We hope to b
 etter understand how stress responses impact nuclear structure and functio
 n\, how this influences cancer cell survival\, ultimately aiming to levera
 ge this to enable translational impacts.\nSpeakers:\nDr Amanda Coutts (Not
 tingham Trent University)
LOCATION:Old Road Campus Research Building (Room 71\, Ground Floor)\, Head
 ington OX3 7DQ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/faf37a0d-a6ac-4b97-b2fc-d340d3f9666a/
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DESCRIPTION:Talk:Nuclear Actin and Links to Splicing and the Nucleolar Str
 ess Response - Dr Amanda Coutts (Nottingham Trent University)
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SUMMARY:A frequent coding polymorphism in the hippo signalling pathway sca
 ffold RASSF1 restricts mechanotransduction to the nucleus and associates w
 ith anxiety disorders\, inflammation and cancer in humans. - Prof Eric O'N
 eill (Department of Oncology\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20250415T093000
DTEND;VALUE=DATE-TIME:20250415T103000
UID:https://talks.ox.ac.uk/talks/id/75b205df-c0bd-4253-8a6b-eb7a2f580d6c/
DESCRIPTION:\nSpeakers:\nProf Eric O'Neill (Department of Oncology\, Unive
 rsity of Oxford)
LOCATION:Wellcome Trust Centre for Human Genetics (Room A+B)\, Headington 
 OX3 7BN
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/75b205df-c0bd-4253-8a6b-eb7a2f580d6c/
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ACTION:display
DESCRIPTION:Talk:A frequent coding polymorphism in the hippo signalling pa
 thway scaffold RASSF1 restricts mechanotransduction to the nucleus and ass
 ociates with anxiety disorders\, inflammation and cancer in humans. - Prof
  Eric O'Neill (Department of Oncology\, University of Oxford)
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SUMMARY:Oxford Stem Cell Institute Annual Symposium 2024 - Professor Angel
 a Russell (Departments of Pharmacology and Chemistry\, University of Oxfor
 d)\, Prof Ahmed Ahmed (University of Oxford\, Weatherall Institute of Mole
 cular Medicine)\, Dr Francesco Boccellato (University of oxford)\, Associa
 te Professor Nicola Smart (DPAG\, University of Oxford)\, Dr Silvia Santos
  (The Francis Crick Institute \, London)\, Professor Igor Adameyko (Karoli
 nska Institute)\, Professor Riccardo Fodde (Erasmus Medical Centre)\, Prof
  Eric O'Neill (Department of Oncology\, University of Oxford)\, Ass Prof A
 ndras Lakatos (Cambridge Stem Cell Institute)\, Prof Luca Magnani (The Ins
 titute for Cancer Research\, London)\, Dr Maria Abad (Altos Labs\, Univers
 ity of Cambridge)\, Dr Anjali Kasumbe (Radcliffe Dpt of Medicine\, Univers
 ity of Oxford)\, Ass Prof Chris Toepfer (Radcliffe Dpt of Medicine\, Unive
 rsity of Oxford)\, Prof Craig MacClean (Dpt of Biology\, University of Oxf
 ord)\, Ass Prof Siim Pauklin (NDORMS\, University of Oxford)\, Prof Steve 
 Pollard (University of Edinburgh)\, Dr Katie Bentley (The Francis Crick In
 stitute\, London)\, Dr Mirjana Efremova (Queen Mary University of London)
DTSTART;VALUE=DATE-TIME:20241024T093000
DTEND;VALUE=DATE-TIME:20241025T183000
UID:https://talks.ox.ac.uk/talks/id/a9ad4f21-380f-4ee2-bf10-2837114e6dbf/
DESCRIPTION:OSCI Symposium is an international event\, unifying scientists
  and clinicians working in stem cells research in various fields of transl
 ational medicine. Event theme: "Stem Cells: From Mechanism to Therapy"\nSp
 eakers:\nProfessor Angela Russell (Departments of Pharmacology and Chemist
 ry\, University of Oxford)\, Prof Ahmed Ahmed (University of Oxford\, Weat
 herall Institute of Molecular Medicine)\, Dr Francesco Boccellato (Univers
 ity of oxford)\, Associate Professor Nicola Smart (DPAG\, University of Ox
 ford)\, Dr Silvia Santos (The Francis Crick Institute \, London)\, Profess
 or Igor Adameyko (Karolinska Institute)\, Professor Riccardo Fodde (Erasmu
 s Medical Centre)\, Prof Eric O'Neill (Department of Oncology\, University
  of Oxford)\, Ass Prof Andras Lakatos (Cambridge Stem Cell Institute)\, Pr
 of Luca Magnani (The Institute for Cancer Research\, London)\, Dr Maria Ab
 ad (Altos Labs\, University of Cambridge)\, Dr Anjali Kasumbe (Radcliffe D
 pt of Medicine\, University of Oxford)\, Ass Prof Chris Toepfer (Radcliffe
  Dpt of Medicine\, University of Oxford)\, Prof Craig MacClean (Dpt of Bio
 logy\, University of Oxford)\, Ass Prof Siim Pauklin (NDORMS\, University 
 of Oxford)\, Prof Steve Pollard (University of Edinburgh)\, Dr Katie Bentl
 ey (The Francis Crick Institute\, London)\, Dr Mirjana Efremova (Queen Mar
 y University of London)
LOCATION:Oxford Martin School (OMS Lecture Theatre\, 1st floor. There is l
 evel access via powered entrance doors\, and then "sesame lift" access up 
 to reception and the ground floor. There is step free and lift access to a
 ll areas apart from the third floor attic level.)\, 34 Broad Street OX1 3B
 D
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/a9ad4f21-380f-4ee2-bf10-2837114e6dbf/
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ACTION:display
DESCRIPTION:Talk:Oxford Stem Cell Institute Annual Symposium 2024 - Profes
 sor Angela Russell (Departments of Pharmacology and Chemistry\, University
  of Oxford)\, Prof Ahmed Ahmed (University of Oxford\, Weatherall Institut
 e of Molecular Medicine)\, Dr Francesco Boccellato (University of oxford)\
 , Associate Professor Nicola Smart (DPAG\, University of Oxford)\, Dr Silv
 ia Santos (The Francis Crick Institute \, London)\, Professor Igor Adameyk
 o (Karolinska Institute)\, Professor Riccardo Fodde (Erasmus Medical Centr
 e)\, Prof Eric O'Neill (Department of Oncology\, University of Oxford)\, A
 ss Prof Andras Lakatos (Cambridge Stem Cell Institute)\, Prof Luca Magnani
  (The Institute for Cancer Research\, London)\, Dr Maria Abad (Altos Labs\
 , University of Cambridge)\, Dr Anjali Kasumbe (Radcliffe Dpt of Medicine\
 , University of Oxford)\, Ass Prof Chris Toepfer (Radcliffe Dpt of Medicin
 e\, University of Oxford)\, Prof Craig MacClean (Dpt of Biology\, Universi
 ty of Oxford)\, Ass Prof Siim Pauklin (NDORMS\, University of Oxford)\, Pr
 of Steve Pollard (University of Edinburgh)\, Dr Katie Bentley (The Francis
  Crick Institute\, London)\, Dr Mirjana Efremova (Queen Mary University of
  London)
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SUMMARY:Oxford Stem Cell Institute Annual Symposium 2022. "Stem Cells: Fro
 m Mechanism to Therapy". - Professor Angela Russell (Departments of Pharma
 cology and Chemistry\, University of Oxford)\, Prof Colin Goding (Ludwig C
 ancer Research\, University of Oxford)\, Associate Professor Nicola Smart 
 (DPAG\, University of Oxford)\, Professor Noel Buckley (Professor of Neuro
 biology\, University of Oxford)\, Prof Ahmed Ahmed (Nuffield Department o
 f Women's & Reproductive Health\, University of Oxford)\, Dr Anjali Kusumb
 e (Radcliffe Department of Medicine\, University of Oxford)\, Prof Chris M
 arine (Centre for Cancer Biology\, Leuven\, Belgium)\, Associate Professor
  Chris Toepfer (Radcliffe Department of Medicine\, University of Oxford)\
 , Dr Francesco Boccellato (Ludwig Institute for Cancer Research\, Univers
 ity of Oxford)\, Dr Kim Jensen (Novo Nordisk Foundation Centre for Stem Ce
 ll Biology DanStem\, Copenhagen\, Denmark)\, Dr Maria Llorens-Martin (Cent
 re for Molecular Biology Severo Ochoa\, Madrid)\, Prof Pete Coffey (UCL)\,
  Dr Silvia Santos (The Francis Crick Institute \, London)\, Dr Srinjan Bas
 u (MRC Cambridge Stem Cell Institute\, University of Cambridge)\, Dr Rocio
  Sancho (King's College London)\, Dr Luana Soares (Department of Physiolog
 y\, Anatomy and Genetics\, University of Oxford)\, Prof Robin Franklin (Al
 tos Labs - Cambridge Institute of Science\, Cambridge)\, Prof Eric O'Neill
  (Department of Oncology\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20221115T093000Z
DTEND;VALUE=DATE-TIME:20221116T173000Z
UID:https://talks.ox.ac.uk/talks/id/0c2884c6-5bac-4f03-a76b-7fc0840a53e7/
DESCRIPTION:The Symposium will highlight areas of stem cell research with 
 trajectories towards treatments of diseases including metabolic disorders\
 , neurodegeneration\, musculoskeletal disease\, heart failure and cancer. 
 \nSpeakers:\nProfessor Angela Russell (Departments of Pharmacology and Che
 mistry\, University of Oxford)\, Prof Colin Goding (Ludwig Cancer Research
 \, University of Oxford)\, Associate Professor Nicola Smart (DPAG\, Univer
 sity of Oxford)\, Professor Noel Buckley (Professor of Neurobiology\, Univ
 ersity of Oxford)\, Prof Ahmed Ahmed (Nuffield Department of Women's & Re
 productive Health\, University of Oxford)\, Dr Anjali Kusumbe (Radcliffe D
 epartment of Medicine\, University of Oxford)\, Prof Chris Marine (Centre 
 for Cancer Biology\, Leuven\, Belgium)\, Associate Professor Chris Toepfe
 r (Radcliffe Department of Medicine\, University of Oxford)\, Dr Francesco
  Boccellato (Ludwig Institute for Cancer Research\, University of Oxford)
 \, Dr Kim Jensen (Novo Nordisk Foundation Centre for Stem Cell Biology Dan
 Stem\, Copenhagen\, Denmark)\, Dr Maria Llorens-Martin (Centre for Molecul
 ar Biology Severo Ochoa\, Madrid)\, Prof Pete Coffey (UCL)\, Dr Silvia San
 tos (The Francis Crick Institute \, London)\, Dr Srinjan Basu (MRC Cambrid
 ge Stem Cell Institute\, University of Cambridge)\, Dr Rocio Sancho (King'
 s College London)\, Dr Luana Soares (Department of Physiology\, Anatomy an
 d Genetics\, University of Oxford)\, Prof Robin Franklin (Altos Labs - Cam
 bridge Institute of Science\, Cambridge)\, Prof Eric O'Neill (Department o
 f Oncology\, University of Oxford)
LOCATION:Oxford Martin School (Numbers will be strictly limited to 100)\, 
 34 Broad Street OX1 3BD
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/0c2884c6-5bac-4f03-a76b-7fc0840a53e7/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Oxford Stem Cell Institute Annual Symposium 2022. "Stem C
 ells: From Mechanism to Therapy". - Professor Angela Russell (Departments 
 of Pharmacology and Chemistry\, University of Oxford)\, Prof Colin Goding 
 (Ludwig Cancer Research\, University of Oxford)\, Associate Professor Nico
 la Smart (DPAG\, University of Oxford)\, Professor Noel Buckley (Professor
  of Neurobiology\, University of Oxford)\, Prof Ahmed Ahmed (Nuffield Dep
 artment of Women's & Reproductive Health\, University of Oxford)\, Dr Anja
 li Kusumbe (Radcliffe Department of Medicine\, University of Oxford)\, Pro
 f Chris Marine (Centre for Cancer Biology\, Leuven\, Belgium)\, Associate 
 Professor Chris Toepfer (Radcliffe Department of Medicine\, University of
  Oxford)\, Dr Francesco Boccellato (Ludwig Institute for Cancer Research\
 , University of Oxford)\, Dr Kim Jensen (Novo Nordisk Foundation Centre fo
 r Stem Cell Biology DanStem\, Copenhagen\, Denmark)\, Dr Maria Llorens-Mar
 tin (Centre for Molecular Biology Severo Ochoa\, Madrid)\, Prof Pete Coffe
 y (UCL)\, Dr Silvia Santos (The Francis Crick Institute \, London)\, Dr Sr
 injan Basu (MRC Cambridge Stem Cell Institute\, University of Cambridge)\,
  Dr Rocio Sancho (King's College London)\, Dr Luana Soares (Department of 
 Physiology\, Anatomy and Genetics\, University of Oxford)\, Prof Robin Fra
 nklin (Altos Labs - Cambridge Institute of Science\, Cambridge)\, Prof Eri
 c O'Neill (Department of Oncology\, University of Oxford)
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