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SUMMARY:C1q in health and disease – roles outside the complement system 
  - Prof Marina Botto (Professor of Rheumatology\,  Imperial College\,  Lon
 don )
DTSTART;VALUE=DATE-TIME:20160712T120000
DTEND;VALUE=DATE-TIME:20160712T130000
UID:https://talks.ox.ac.uk/talks/id/81da18b5-6ec0-4d33-86e7-0e9d2d05a84a/
DESCRIPTION:Marina Botto FMedSci is the Director of the Centre for Complem
 ent and Inflammation Research (CCIR) and Professor of Rheumatology at the 
 Imperial College London. She is also a Consultant Rheumatologist at Imperi
 al Academic Health Science Centre\, Hammersmith Campus.\n\nThe focus of he
 r research programme is to understand how complement deficiency contribute
 s to the autoimmune disease\, systemic lupus erythematosus (SLE). Her labo
 ratory is particularly interested in understanding the consequences of inh
 erited complement deficiencies in humans and the role(s) that the compleme
 nt system plays in the clearance of dying cells as well as immune complexe
 s. Using in vivo models\, genetic and cellular approaches and experimental
  models of inflammation she has demonstrated that: i) inherited defects in
  the pathways for clearance of cellular debris and immune complexes predis
 pose to the development of SLE\; ii) there is a link between spontaneous a
 utoimmunity and abnormalities of the physiological clearance of apoptotic 
 cells in humans with complement deficiency\; iii) the complement system mo
 dulates the adaptive immune system\; iv) autoimmunity varies according to 
 the genetic background of the model used and identified lupus susceptibili
 ty loci. The laboratory currently aims to delineate the contribution of co
 mplement system in the induction and resolution of inflammation and to def
 ine the mechanisms by which the complement system regulates the tolerance 
 to self-antigens.\nSpeakers:\nProf Marina Botto (Professor of Rheumatology
 \,  Imperial College\,  London )
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre
 )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/81da18b5-6ec0-4d33-86e7-0e9d2d05a84a/
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DESCRIPTION:Talk:C1q in health and disease – roles outside the complemen
 t system  - Prof Marina Botto (Professor of Rheumatology\,  Imperial Colle
 ge\,  London )
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