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SUMMARY:Targeting the glutamate system to treat schizophrenia  - Dr Kather
 ine Beck (King's College London)
DTSTART;VALUE=DATE-TIME:20250603T093000
DTEND;VALUE=DATE-TIME:20250603T103000
UID:https://talks.ox.ac.uk/talks/id/1af8883c-b439-4e6d-85fa-49ff2aa864ec/
DESCRIPTION:Schizophrenia is a leading cause of global disability\, affect
 ing approximately 1% of the population. Multiple lines of evidence suggest
  that there are alterations in the glutamate system and the glutamate rece
 ptor\, N-methyl-D-aspartate (NMDA)\, in individuals with schizophrenia. Po
 st-mortem investigations reveal changes in NMDA receptors across different
  brain regions. More recently\, studies utilising Positron Emission Tomogr
 aphy (PET) imaging have identified lower NMDA receptor levels in the hippo
 campus relative to other brain regions in people with schizophrenia compar
 ed to healthy individuals. \nStudies using proton magnetic resonance spect
 roscopy (1H-MRS) have enabled the in vivo examination of glutamate and its
  metabolic\, glutamine. They have found region-specific alterations in peo
 ple with schizophrenia. This talk will explore the latest findings from th
 ese studies and the implications for drug development. This will include t
 he review of glycine type 1 transporter inhibitors and drugs targeting bra
 in glutamate such as riluzole as potential treatments for schizophrenia. \
 nThis talk will also critically review the success and setbacks in drug di
 scovery for these targets\, discussing the underlying reasons. \nAdditiona
 lly\, the potential utility of neuroimaging in guiding future drug develop
 ment in this area will be explored. \n\nThis seminar is hosted in person a
 t the Department of Psychiatry\, Seminar Room & online. To join online\, p
 lease use the Zoom details below:\nzoom.us/j/92620728590?pwd=s1JefrGff6bN0
 nZZcHSTBkCw8Z1RlT.1\nMeeting ID: 926 2072 8590\nPasscode: 196542\nSpeakers
 :\nDr Katherine Beck (King's College London)
LOCATION:Department of Psychiatry (Seminar Room)\, Headington OX3 7JX
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/1af8883c-b439-4e6d-85fa-49ff2aa864ec/
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DESCRIPTION:Talk:Targeting the glutamate system to treat schizophrenia  - 
 Dr Katherine Beck (King's College London)
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