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SUMMARY:Lost in Space: Linking Spatial Disorientation to Preclinical Alzhe
 imer’s Disease in Mice and Humans - Dr Tim Viney (Department of Pharmaco
 logy\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20250124T130000Z
DTEND;VALUE=DATE-TIME:20250124T140000Z
UID:https://talks.ox.ac.uk/talks/id/c571ef5a-239d-4a59-9bd5-3731fbc91b2d/
DESCRIPTION:We use a combination of egocentric (body-derived) and allocent
 ric (landmark-based) cues to navigate. This ability can become impaired du
 ring ageing\, leading to spatial disorientation\, which an early sign of d
 ementia. Which neural circuits are responsible for disorientation? The ant
 erodorsal nucleus of the thalamus (ADn) contains a high density of head di
 rection (HD) cells that act like a ‘neural compass’. Head direction si
 gnals from the ADn are sent to postsynaptic cortical areas such as the ret
 rosplenial cortex\, which are important for spatial orientation and naviga
 tion. The human ADn is highly susceptible to neurodegeneration in Alzheime
 r’s disease\, the most common form of dementia. We tested the hypothesis
  that very early pathological changes in the ADn give rise to spatial diso
 rientation. A major pathological hallmark of multiple neurodegenerative di
 seases\, including Alzheimer’s disease\, is the presence of amyloid fibr
 ils. Using light and electron microscopy\, we detected amyloid fibrils in 
 neuronal cell bodies\, dendritic appendages\, and axon terminals within po
 st-mortem human ADn\, identifying them as aggregates of pathological tau (
 ptau). We detected ptau in the ADn at all disease stages\, including in ca
 ses that lacked any known cognitive impairment\, cases with mild cognitive
  impairment\, and in Alzheimer’s disease cases. Calretinin-expressing ne
 urons preferentially accumulated ptau. We also localized ptau to large vGL
 UT2-expressing presynaptic terminals from the mammillary body but not to c
 orticothalamic terminals\, suggesting a prime site for the transsynaptic s
 pread of ptau. To test whether ptau affects HD signalling\, we virally exp
 ressed human tau in the ADn of adult mice (HD-ptau mice). Despite being ab
 le to learn spatial memory tasks\, HD-ptau mice exhibited looping behaviou
 r when searching for hidden goals in a Morris water maze and made a greate
 r number of head turns during memory recall\, suggesting they were disorie
 nted. By recording and labelling single HD cells in awake HD-ptau mice\, w
 e found that ADn cells exhibited reduced directionality and altered burst 
 firing patterns. In conclusion\, the unusually high vulnerability of this 
 subcortical head direction circuit to tau amyloid fibrils may contribute t
 o disorientation in preclinical Alzheimer’s disease. This information co
 uld be used to identify individuals most likely to develop memory impairme
 nts\, leading to earlier intervention strategies and targeted therapies.\n
 \nSPEAKER BIOGRAPHY\n\nDr Viney is a Career Development Fellow in the Depa
 rtment of Pharmacology\, University of Oxford\, and a Research Fellow at W
 olfson College\, Oxford. His research group investigates the link between 
 amyloid fibrils and spatial memory in both animal models and post-mortem h
 uman brain tissue.\n\nHe has a Master of Biology degree in Molecular & Cel
 lular Biology from the University of Bath\, UK\, and a PhD in Neuroscience
  from the Friedrich Miescher Institute in Basel\, Switzerland. His PhD res
 earch\, conducted in the group of Dr Botond Roska\, focused on defining di
 fferent types of ganglion cells and amacrine cells in the mammalian retina
 . He defined the presynaptic inputs to melanopsin-expressing ganglion cell
 s (Viney et al Curr Biol 2007) and demonstrated that ‘approach sensitive
 ’ ganglion cells receive glycinergic inhibition from AII amacrine cells.
 \n\nAfter his PhD\, Dr Viney joined the group of Professor Peter Somogyi a
 t the MRC Anatomical Neuropharmacology Unit in Oxford where he investigate
 d the spike timing of identified GABAergic neurons and pyramidal cells in 
 the hippocampus of freely moving rats. He discovered a marker for axo-axon
 ic cells and demonstrated that this cell type stops firing during high-fre
 quency ripple oscillations in sleeping rats (Viney et al Nat Neuro 2013). 
 This was followed by research defining GABAergic projection neurons of the
  mouse basal forebrain. He discovered and defined ‘orchid cells’\, whi
 ch provide theta-rhythmic inhibition to GABAergic interneurons in the pres
 ubiculum and entorhinal cortex (Viney et al eLife 2018)\, and along with h
 is first DPhil student\, defined GABAergic projection neurons with low-rhy
 thmic firing that innervated hippocampal CA3 (Salib et al J Neurosci 2019)
 .\n\nIn 2019\, Dr Viney applied for a competitive Career Development Fello
 wship in the Department of Pharmacology. He was awarded the fellowship\, w
 hich started in 2020. Dr Viney’s recent research has involved investigat
 ing how amyloid fibrils of tau spread in the human brain (Sarkany et al Ac
 ta Neuropathologica 2024) and in mouse models (Viney et al Cell Reports 20
 22). His group is currently investigating how dysfunction of thalamic head
  direction cells affects spatial orientation (Jiang and Hijazi et al BioRx
 iv 2024). As a Research Fellow at Wolfson College\, he runs the Mind\, Bra
 in & Behaviour Research Cluster. Recent funding sources include the Medica
 l Research Council and the Alzheimer’s Society.\nSpeakers:\nDr Tim Viney
  (Department of Pharmacology\, University of Oxford)
LOCATION:Sherrington Library (Sherrington Building)\, off Parks Road OX1 3
 PT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/c571ef5a-239d-4a59-9bd5-3731fbc91b2d/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Lost in Space: Linking Spatial Disorientation to Preclini
 cal Alzheimer’s Disease in Mice and Humans - Dr Tim Viney (Department of
  Pharmacology\, University of Oxford)
TRIGGER:-PT1H
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BEGIN:VEVENT
SUMMARY:Chemical tools to study molecular events at synapses - Associate P
 rofessor Frederic Menard (Department of Chemistry\, University of British 
 Columbia)
DTSTART;VALUE=DATE-TIME:20241015T120000
DTEND;VALUE=DATE-TIME:20241015T130000
UID:https://talks.ox.ac.uk/talks/id/688b7f02-a02c-4f49-b23b-16eddde16a87/
DESCRIPTION:Our lab develops chemical tools to study proteins dynamics in 
 living cells without genetic modifications—with a stong focus on neuron-
 glia interactions. In the brain\, synaptic connections are the foundation 
 of a healthy neuronal network. Uncontrolled loss of these connections can 
 lead to neurological diseases like Alzheimer and Parkinson. The phenotypes
  are well studied\, but the molecular processes that dictate whether a syn
 apse will get strengthened or destroyed are still not understood. Membrane
  proteins involved in cellular communication control the fate of a synapse
  and must be studied in living cells to gain meaningful insight. Chemical 
 approaches offer alternative solutions to current genetic methods.\n\nThis
  talk will highlight how small molecules can be modified to monitor\, tag\
 , or control proteins involved in critical neurobiological processes. They
  include membrane proteins such as: glutamate receptors\, voltage-gated ca
 lcium channels\, integrins\, and neurexin. We have created a number of mol
 ecular probes that can be used as functional reporters or as activity-trig
 gers of cellular activity. Together\, these small molecules help us gain u
 nprecedented insight in the function of native proteins in cells like neur
 ons.\nSpeakers:\nAssociate Professor Frederic Menard (Department of Chemis
 try\, University of British Columbia)
LOCATION:Pharmacology (David Smith Lecture Theatre)\, off Mansfield Road O
 X1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/688b7f02-a02c-4f49-b23b-16eddde16a87/
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ACTION:display
DESCRIPTION:Talk:Chemical tools to study molecular events at synapses - As
 sociate Professor Frederic Menard (Department of Chemistry\, University of
  British Columbia)
TRIGGER:-PT1H
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BEGIN:VEVENT
SUMMARY:Egocentric and allocentric representations in cortical structures 
 - Professor Michael Hasselmo (Center for Systems Neuroscience\, Boston Uni
 versity)
DTSTART;VALUE=DATE-TIME:20240501T160000
DTEND;VALUE=DATE-TIME:20240501T170000
UID:https://talks.ox.ac.uk/talks/id/03b290ad-7f7e-42dd-8832-1f560a4b7f47/
DESCRIPTION:\nSpeakers:\nProfessor Michael Hasselmo (Center for Systems Ne
 uroscience\, Boston University)
LOCATION:Pharmacology (David Smith Lecture Theatre)\, off Mansfield Road O
 X1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/03b290ad-7f7e-42dd-8832-1f560a4b7f47/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Egocentric and allocentric representations in cortical st
 ructures - Professor Michael Hasselmo (Center for Systems Neuroscience\, B
 oston University)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:The impact of microglia on neuronal function and brain plasticity 
 - Assistant Professor Sandra Siegert (Institute of Science and Technology 
 Austria (ISTA))
DTSTART;VALUE=DATE-TIME:20240305T120000Z
DTEND;VALUE=DATE-TIME:20240305T130000Z
UID:https://talks.ox.ac.uk/talks/id/1ae0e109-a66b-496a-aa5b-ea8bc9ed683e/
DESCRIPTION:\nSpeakers:\nAssistant Professor Sandra Siegert (Institute of 
 Science and Technology Austria (ISTA))
LOCATION:Pharmacology (David Smith Lecture Theatre)\, off Mansfield Road O
 X1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/1ae0e109-a66b-496a-aa5b-ea8bc9ed683e/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:The impact of microglia on neuronal function and brain pl
 asticity - Assistant Professor Sandra Siegert (Institute of Science and Te
 chnology Austria (ISTA))
TRIGGER:-PT1H
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END:VEVENT
BEGIN:VEVENT
SUMMARY:Cortex and beyond: an evolutionary perspective on visual circuits 
 for action - Assistant Professor Sarah Ruediger (Wellcome Trust CDA Fellow
 \, University College London)
DTSTART;VALUE=DATE-TIME:20231017T120000
DTEND;VALUE=DATE-TIME:20231017T130000
UID:https://talks.ox.ac.uk/talks/id/d6242191-4449-4e77-ba7a-92539efa402e/
DESCRIPTION:\nSpeakers:\nAssistant Professor Sarah Ruediger (Wellcome Trus
 t CDA Fellow\, University College London)
LOCATION:Pharmacology (David Smith Lecture Theatre)\, off Mansfield Road O
 X1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/d6242191-4449-4e77-ba7a-92539efa402e/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Cortex and beyond: an evolutionary perspective on visual 
 circuits for action - Assistant Professor Sarah Ruediger (Wellcome Trust C
 DA Fellow\, University College London)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Building a flexible sensory cortex: Function and dysfunction - Dr 
 Abhishek Banerjee (Newcastle University)
DTSTART;VALUE=DATE-TIME:20230307T120000Z
DTEND;VALUE=DATE-TIME:20230307T130000Z
UID:https://talks.ox.ac.uk/talks/id/9653c89c-1a97-4aaf-bcd0-ae540cfa29bc/
DESCRIPTION:Animals adapt their behaviour in response to variable changes 
 in reward reinforcement. The prefrontal areas of the mammalian neocortex\,
  especially the orbitofrontal cortex (OFC)\, play an important role in inv
 oking rule-based strategies to enable flexible learning. However\, the neu
 ral circuit mechanisms in OFC and its hierarchical interactions with senso
 ry areas underlying such processes remain elusive. In my talk\, using a ta
 ctile reversal-learning task in mice\, I will discuss cellular and circuit
  interactions between orbitofrontal and somatosensory cortices that guide 
 flexible tactile decision-making. I will also present data on how flexible
  behaviour and feedback regulation of sensory processing is disrupted in a
 nimal models of autism spectrum disorders. \nSpeakers:\nDr Abhishek Banerj
 ee (Newcastle University)
LOCATION:Pharmacology (David Smith Lecture Theatre)\, off Mansfield Road O
 X1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/9653c89c-1a97-4aaf-bcd0-ae540cfa29bc/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Building a flexible sensory cortex: Function and dysfunct
 ion - Dr Abhishek Banerjee (Newcastle University)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Effects of pathological Tau on hippocampal neuronal activity and s
 patial memory in ageing mice - Dr Tim Viney (Department of Pharmacology\, 
 University of Oxford)
DTSTART;VALUE=DATE-TIME:20220211T160000Z
DTEND;VALUE=DATE-TIME:20220211T170000Z
UID:https://talks.ox.ac.uk/talks/id/0323aa22-d226-42d0-97cf-77e613501b55/
DESCRIPTION:The gradual accumulation of hyperphosphorylated forms of the T
 au protein (pTau) in the human brain correlate with cognitive dysfunction 
 and neurodegeneration. I will present our recent findings on the consequen
 ces of human pTau aggregation in the hippocampal formation of a mouse tauo
 pathy model. We show that pTau preferentially accumulates in deep-layer py
 ramidal neurons\, leading to their neurodegeneration. In aged but not youn
 ger mice\, pTau spreads to oligodendrocytes. During ‘goal-directed’ na
 vigation\, we detect fewer high-firing pyramidal cells\, but coupling to n
 etwork oscillations is maintained in the remaining cells. The firing patte
 rns of individually recorded and labelled pyramidal and GABAergic neurons 
 are similar in transgenic and non-transgenic mice\, as are network oscilla
 tions\, suggesting intact neuronal coordination. This is consistent with a
  lack of pTau in subcortical brain areas that provide rhythmic input to th
 e cortex. Spatial memory tests reveal a reduction in short-term familiarit
 y of spatial cues but unimpaired spatial working and reference memory. The
 se results suggest that preserved subcortical network mechanisms compensat
 e for the widespread pTau aggregation in the hippocampal formation. I will
  also briefly discuss ideas on the subcortical origins of spatial memory a
 nd the concept of the cortex as a monitoring device.\nSpeakers:\nDr Tim Vi
 ney (Department of Pharmacology\, University of Oxford)
LOCATION:Sherrington Building (Blakemore Theater\; If you cannot enter She
 rrington Building\, please email antaramaj16@gmail.com and we will send so
 meone to open the front doors for you. )\, off Parks Road OX1 3PT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/0323aa22-d226-42d0-97cf-77e613501b55/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Effects of pathological Tau on hippocampal neuronal activ
 ity and spatial memory in ageing mice - Dr Tim Viney (Department of Pharma
 cology\, University of Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Microcircuit determinants of hippocampal oscillatory activity - Pr
 ofessor Liset M de la Prida (Instituto Cajal - CSIC)
DTSTART;VALUE=DATE-TIME:20220222T120000Z
DTEND;VALUE=DATE-TIME:20220222T130000Z
UID:https://talks.ox.ac.uk/talks/id/f74ab0a2-4a9e-4a7f-aa19-10abbe07dad7/
DESCRIPTION:\nSpeakers:\nProfessor Liset M de la Prida (Instituto Cajal - 
 CSIC)
LOCATION:Venue to be announced
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f74ab0a2-4a9e-4a7f-aa19-10abbe07dad7/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Microcircuit determinants of hippocampal oscillatory acti
 vity - Professor Liset M de la Prida (Instituto Cajal - CSIC)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Hypothalamic glutamatergic-vasopressin ascending projections invol
 ved in anxiety\, avoidance and motivated behaviours - Professor Limei Zhan
 g (Department of Physiology\, National Autonomous University of Mexico)
DTSTART;VALUE=DATE-TIME:20211012T120000
DTEND;VALUE=DATE-TIME:20211012T130000
UID:https://talks.ox.ac.uk/talks/id/4ddc121d-ea9f-4746-b8cd-89b96fb498d2/
DESCRIPTION:\nSpeakers:\nProfessor Limei Zhang (Department of Physiology\,
  National Autonomous University of Mexico)
LOCATION:Pharmacology (Online via Teams)\, off Mansfield Road OX1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/4ddc121d-ea9f-4746-b8cd-89b96fb498d2/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Hypothalamic glutamatergic-vasopressin ascending projecti
 ons involved in anxiety\, avoidance and motivated behaviours - Professor L
 imei Zhang (Department of Physiology\, National Autonomous University of M
 exico)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Career Progression - Tamar Farfel (aMoon)\, Dr Tim Viney (Departme
 nt of Pharmacology\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20200706T120000
DTEND;VALUE=DATE-TIME:20200706T130000
UID:https://talks.ox.ac.uk/talks/id/6b628fdc-03f1-4338-9ad0-dbf4e4219bc8/
DESCRIPTION:This seminar will be particularly suited for early career rese
 archers who are looking for advice on how to progress to the next stage in
  their career\, either within academia or in industry\, however the semina
 r is open to all who would like to attend.\n\nAccess the Teams seminar her
 e: https://teams.microsoft.com/l/meetup-join/19%3ameeting_YTU0ZTE5ZjAtODNl
 Yi00NTc2LTk0ODAtN2NjNGQ3ZGEzNTE0%40thread.v2/0?context=%7b%22Tid%22%3a%22c
 c95de1b-97f5-4f93-b4ba-fe68b852cf91%22%2c%22Oid%22%3a%22310a88c3-19fe-4178
 -8106-cea07748010c%22%7d\nSpeakers:\nTamar Farfel (aMoon)\, Dr Tim Viney (
 Department of Pharmacology\, University of Oxford)
LOCATION:Online via Teams
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/6b628fdc-03f1-4338-9ad0-dbf4e4219bc8/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Career Progression - Tamar Farfel (aMoon)\, Dr Tim Viney 
 (Department of Pharmacology\, University of Oxford)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Alzheimer's disease: the interaction between amyloid beta\, synaps
 es and microglia - Professor Frances Edwards (University College London (U
 CL))
DTSTART;VALUE=DATE-TIME:20200204T120000Z
DTEND;VALUE=DATE-TIME:20200204T130000Z
UID:https://talks.ox.ac.uk/talks/id/ee0d85d2-913b-4ee5-9fe0-d80191407e03/
DESCRIPTION:\nSpeakers:\nProfessor Frances Edwards (University College Lon
 don (UCL))
LOCATION:Pharmacology (Lecture Theatre)\, off Mansfield Road OX1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/ee0d85d2-913b-4ee5-9fe0-d80191407e03/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Alzheimer's disease: the interaction between amyloid beta
 \, synapses and microglia - Professor Frances Edwards (University College 
 London (UCL))
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Remembering the mammillary bodies: from relay to orchestrator - Pr
 ofessor Seralynne Vann (School of Psychology\, Cardiff University)
DTSTART;VALUE=DATE-TIME:20191126T120000Z
DTEND;VALUE=DATE-TIME:20191126T130000Z
UID:https://talks.ox.ac.uk/talks/id/10b45584-6a4a-4f6d-8e07-f82926bcdee3/
DESCRIPTION:\nStatus: This talk has been cancelled\n\nSpeakers:\nProfessor
  Seralynne Vann (School of Psychology\, Cardiff University)
LOCATION:Pharmacology (Lecture Theatre)\, off Mansfield Road OX1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/10b45584-6a4a-4f6d-8e07-f82926bcdee3/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Remembering the mammillary bodies: from relay to orchestr
 ator - Professor Seralynne Vann (School of Psychology\, Cardiff University
 )
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Septo-hippocampal circuitry beyond theta generation: how hippocamp
 al spatial code is tuned by septal activity - Dr Marian Tsanov (Wellcome T
 rust RCD Fellow\, Trinity College Dublin)
DTSTART;VALUE=DATE-TIME:20181127T120000Z
DTEND;VALUE=DATE-TIME:20181127T130000Z
UID:https://talks.ox.ac.uk/talks/id/edc29246-9e5d-47c4-a923-72360c4824d9/
DESCRIPTION:\nSpeakers:\nDr Marian Tsanov (Wellcome Trust RCD Fellow\, Tri
 nity College Dublin)
LOCATION:Pharmacology (Lecture Theatre)\, off Mansfield Road OX1 3QT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/edc29246-9e5d-47c4-a923-72360c4824d9/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Septo-hippocampal circuitry beyond theta generation: how 
 hippocampal spatial code is tuned by septal activity - Dr Marian Tsanov (W
 ellcome Trust RCD Fellow\, Trinity College Dublin)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR