BEGIN:VCALENDAR VERSION:2.0 PRODID:talks.ox.ac.uk BEGIN:VEVENT SUMMARY:Discovery of the telomere transfer biology and its link to the fir st HIV cure - Prof Alessio Lanna (UCL) DTSTART;VALUE=DATE-TIME:20251010T120000 DTEND;VALUE=DATE-TIME:20251010T130000 UID:https://talks.ox.ac.uk/talks/id/dd89d602-e8c5-494f-9590-1105e7183fcd/ DESCRIPTION:When T cells get younger\, the body remembers how to heal. At the onset of their lifespan\, CD4⁺ T cells unleash a regenerative code: telomere “Rivers” transferred from antigen-presenting cells spread you th across aged tissues and organisms. This transfer biology also dismantle s HIV latency — enabling the first functional cure. Medicating this proc ess revives terminally differentiated T cells\, restores telomeric length\ , and reprograms stem-like responses. Rather than terminal decline\, the e nd of a T cell marks renewal and reveals properties not previously existen t. Age\, once a boundary\, becomes reversible — through the flow of telo meres. Thus\, the immune system possesses self-healing properties that can be transplanted.\nSpeakers:\nProf Alessio Lanna (UCL) LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea dington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/dd89d602-e8c5-494f-9590-1105e7183fcd/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Discovery of the telomere transfer biology and its link t o the first HIV cure - Prof Alessio Lanna (UCL) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Seminar by Dr Shiladitya Sengupta "When nanoscience throws surpris ing insights into cancer biology" - Dr Shiladitya Sengupta (Harvard - MIT) DTSTART;VALUE=DATE-TIME:20221027T120000 DTEND;VALUE=DATE-TIME:20221027T130000 UID:https://talks.ox.ac.uk/talks/id/deccc465-58c6-41e6-ba20-797d29f37e51/ DESCRIPTION:Dr. Shiladitya Sengupta is an associate professor of medicine and HST at Harvard Medical School and leads the center for engineered ther apeutics at the Mass General-Brigham Hospital. His laboratory use tools fr om nanotechnology and bioengineering to explore biological phenomenon at d istinct scales\, and to design new therapeutics. For example\, he develope d the first layer-by-layer nanoparticle that allows targeting different co mponents of a tumor on a temporal scale (Nature). Recently\, his lab disco vered a new mechanism of tumor immune evasion\, where the cancer cells har vest immune cell mitochondria (Nature Nanotechnology). Many of his invent ions/research have led to start-ups (he cofounded Cerulean Pharma\, Vyome Therapeutics\, Farcast Biosciences\, Allysum Therapeutics\, which have rai sed over $300M in R&D funding)\, or been commercialized (Nimulid™\, CANS cript™\, MRT-technology in Anaboom™\, VT1953 in Phase 3 trials\, AT196 5 entering Phase 1 trials). Over 100 students and postdoctoral fellows hav e trained in his laboratory\, have won multiple awards and fellowships\, a nd have gone on to successful careers in academia and in the biotech indus try. He has received the TR35 Top 35 Global Innovators award from MIT Tech nology Review magazine\, the Era of Hope scholar award from US Department of Defense\, etc. He completed his undergraduate education at the All Indi a Institute of Medical Sciences\, New Delhi\, his PhD in Pharmacology as a Nehru and Chevening scholar from Trinity College\, Cambridge University\, and his fellowship in biological engineering at Massachusetts Institute o f Technology\, before joining Harvard as faculty.\nSpeakers:\nDr Shiladity a Sengupta (Harvard - MIT) LOCATION:Kennedy Institute of Rheumatology (This seminar will be held in t he Kennedy Institute Lecture Theatre is open to all Oxford University memb ers. There is also the option to join via Zoom https://medsci.zoom.us/meet ing/register/tJwtceCqrTMoE9DLlZ2QUx6Zi1Cuy5Wn7k0M)\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/deccc465-58c6-41e6-ba20-797d29f37e51/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Seminar by Dr Shiladitya Sengupta "When nanoscience throw s surprising insights into cancer biology" - Dr Shiladitya Sengupta (Harva rd - MIT) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Syndecan proteoglycans: gatekeepers of the cell adhesion phenotype - Professor John Couchman (Biotech Research & Innovation Centre (BRIC) Un iversity of Copenhagen) DTSTART;VALUE=DATE-TIME:20170719T160000 DTEND;VALUE=DATE-TIME:20170719T170000 UID:https://talks.ox.ac.uk/talks/id/9ad2cb73-018e-4f9b-866c-49a43dc27504/ DESCRIPTION:\nSpeakers:\nProfessor John Couchman (Biotech Research & Innov ation Centre (BRIC) University of Copenhagen) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/9ad2cb73-018e-4f9b-866c-49a43dc27504/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Syndecan proteoglycans: gatekeepers of the cell adhesion phenotype - Professor John Couchman (Biotech Research & Innovation Centre (BRIC) University of Copenhagen) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Cytosolic RNA sensing in T-dependent immunity - Prof Cecile King ( Associate Professor Department of Immunology Garvan Institute of Medical Research) DTSTART;VALUE=DATE-TIME:20170418T120000 DTEND;VALUE=DATE-TIME:20170418T130000 UID:https://talks.ox.ac.uk/talks/id/9e8d0231-af78-47dd-b20f-07801966f78a/ DESCRIPTION:Associate Professor Cecile King is an immunologist/cell biolog ist investigating the regulation of immune responses in health and disease . A broad objective of this work is to analyse pathways that can be modula ted to improve immunity in individuals during vaccination\, and limit immu ne responses that cause damage to both endogenous tissues and transplanted tissues in autoimmune diseases.\nA/Professor King received her PhD from t he Telethon Institute for Child Health\, University of Western Australia a nd completed her postdoctoral training at the Scripps Research Institute\, La Jolla\, USA. She joined the faculty of the Department of Immunology at the Garvan Institute of Medical Research\, Sydney\, Australia in 2005 and is an Associate Professor at the Department of Medicine\, University of N ew South Wales.\nDr King continues to be intrigued by how the immune syste m maintains tolerance to self. Her research is focused on how interactions between the environment and immune system influence chronic inflammation and autoimmune disease. Dr King has made important contributions to our un derstanding of how cytokines influence adaptive immune responses\, includi ng T follicular helper cell differentiation during the germinal center rea ction and the identification of IL-21 as a therapeutic target for autoimmu ne diabetes. Dr King’s interests include integrating the world of RNA se nsing and genes within type 1 IFN regulatory pathways with autoimmune dise ase and adaptive immune responses.\n\n\nSpeakers:\nProf Cecile King (Assoc iate Professor Department of Immunology Garvan Institute of Medical Resea rch) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/9e8d0231-af78-47dd-b20f-07801966f78a/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Cytosolic RNA sensing in T-dependent immunity - Prof Ceci le King (Associate Professor Department of Immunology Garvan Institute of Medical Research) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Molecular mechanisms of the TGFß signalling pathway in human stem cell fate choice\, tissue formation and disease - Dr Siim Pauklin (Univer sity of Cambridge) DTSTART;VALUE=DATE-TIME:20170320T120000Z DTEND;VALUE=DATE-TIME:20170320T130000Z UID:https://talks.ox.ac.uk/talks/id/a484668d-2543-40bf-a14a-77e4721fc716/ DESCRIPTION:My work as a postdoctoral research associate includes both sci entific research as well as mentoring and teaching. My scientific studies focus on transcriptional and epigenetic mechanisms that govern cell fate c hoice of human pluripotent stem cells and tissue formation via the TGFß/N odal-Smad2/3 signalling pathway. I provide research supervision to my youn ger colleagues and I am on the Editorial board of an international journal for stem cell research. My teaching responsibilities include presenting u niversity lectures to PhD students on stem cells\, tumorigenesis and cance r stem cells. \nSpeakers:\nDr Siim Pauklin (University of Cambridge) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/a484668d-2543-40bf-a14a-77e4721fc716/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Molecular mechanisms of the TGFß signalling pathway in h uman stem cell fate choice\, tissue formation and disease - Dr Siim Paukli n (University of Cambridge) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:T-B Crosstalk on the Germinal Centre Road to Memory - Prof Hai Qi (Professor\, School of Medicine\, Tsinghua University\, China) DTSTART;VALUE=DATE-TIME:20170306T103000Z DTEND;VALUE=DATE-TIME:20170306T113000Z UID:https://talks.ox.ac.uk/talks/id/e8073da3-66bd-480e-98eb-03ce83663948/ DESCRIPTION:Dr. Hai Qi received a Bachelor of Medicine from the Beijing Me dical University in 1996 and a Ph.D. in Pathology from the University of T exas Medical Branch at Galveston in 2003. After postdoctoral training at N IH with Dr. Ronald Germain\, in 2009 he joined the faculty of Tsinghua Uni versity\, where he is currently a Professor in Immunology. His group studi es follicular helper T (Tfh) cells and germinal center biology with a part icular emphasis on cell-cell interactions\, cell migration\, and functiona l specialization. In this talk\, Dr. Qi will present new findings on how t erritoriality and function of follicular helper T cells are regulated in t he germinal center niche and how T cells impinge on the development of mem ory B cells.\nSpeakers:\nProf Hai Qi (Professor\, School of Medicine\, Ts inghua University\, China) LOCATION:NDM Building (NDM lecture theatre)\, Headington OX3 7FZ TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/e8073da3-66bd-480e-98eb-03ce83663948/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:T-B Crosstalk on the Germinal Centre Road to Memory - Pro f Hai Qi (Professor\, School of Medicine\, Tsinghua University\, China) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Novel Kinases controlling T cell development\, trafficking and imm une responses - Dr Robert Köechl (The Francis Crick Institute) DTSTART;VALUE=DATE-TIME:20170130T120000Z DTEND;VALUE=DATE-TIME:20170130T130000Z UID:https://talks.ox.ac.uk/talks/id/32d427d8-f21b-416e-ba3b-5894999bee31/ DESCRIPTION:I grew up in Austria and studied Biology at the University of Innsbruck. For my diploma thesis\, I went to Berlin where I worked in Ralf Schülein’s group at the Research Institute of Molecular Pharmacology i nvestigating the intracellular transport of G-protein coupled receptors. A fter finishing my degree\, I moved to London to study for my PhD in Sharon Tooze’s lab at Cancer Research UK’s London Research Institute\, where I studied the fusion mechanisms of autophagosomes with early and late end osomes. Keeping in line with my interest in signaling and cell biology I t hen started as a postdoc in Victor Tybulewicz’s lab at the MRC National Institute for Medical Research - now the Francis Crick Institute - to work on the role of kinases in T cell biology.\nSpeakers:\nDr Robert Köechl ( The Francis Crick Institute) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/32d427d8-f21b-416e-ba3b-5894999bee31/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Novel Kinases controlling T cell development\, traffickin g and immune responses - Dr Robert Köechl (The Francis Crick Institute) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Innate lymphoid cells orchestrate organ homeostasis - Prof Andreas Diefenbach (Chair of Medical Microbiology Coordinator of the Research Cen tre of Immunology Johannes-Gutenberg-University of Mainz\, Germany) DTSTART;VALUE=DATE-TIME:20161128T120000Z DTEND;VALUE=DATE-TIME:20161128T130000Z UID:https://talks.ox.ac.uk/talks/id/859b4160-a846-4cfb-ac4a-253ea6b0ec66/ DESCRIPTION:\nSpeakers:\nProf Andreas Diefenbach (Chair of Medical Microbi ology Coordinator of the Research Centre of Immunology Johannes-Gutenberg- University of Mainz\, Germany) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/859b4160-a846-4cfb-ac4a-253ea6b0ec66/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Innate lymphoid cells orchestrate organ homeostasis - Pro f Andreas Diefenbach (Chair of Medical Microbiology Coordinator of the Res earch Centre of Immunology Johannes-Gutenberg-University of Mainz\, German y) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Novel mechanisms regulating B cell activation - Prof Bebhinn Trean or (University of Toronto) DTSTART;VALUE=DATE-TIME:20160923T120000 DTEND;VALUE=DATE-TIME:20160923T130000 UID:https://talks.ox.ac.uk/talks/id/5312d2db-d2a1-407f-abc1-812a6fcff635/ DESCRIPTION:Bebhinn is Assistant Professor at the university of Toronto\, Canada since 2011. Her current research investigates the potential for ext racellular regulatory mechanisms for receptor organization\, such as glyca n-based domains generated by the binding of galectins to cell surface glyc oproteins. The galectins are a family of lectins that can bind ?-galactosi de on cell surface glycoproteins to form an extracellular molecular lattic e. Her laboratory uses advanced optical microscopy techniques to explore h ow these cell-surface scaffolding proteins could modulate the interaction\ , function and turnover of immune cell glycoproteins.\nSpeakers:\nProf Beb hinn Treanor (University of Toronto) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/5312d2db-d2a1-407f-abc1-812a6fcff635/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Novel mechanisms regulating B cell activation - Prof Bebh inn Treanor (University of Toronto) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Probiotic and Prebiotic modulation of Brain Function - Dr Philip B urnet (ASSOCIATE PROFESSOR AND DIRECTOR OF GRADUATE STUDIES) DTSTART;VALUE=DATE-TIME:20160912T120000 DTEND;VALUE=DATE-TIME:20160912T130000 UID:https://talks.ox.ac.uk/talks/id/9388d7a2-757b-49ef-a501-4f0fb293b34c/ DESCRIPTION:Dr Burnet received a BSc (Hons) in Biochemistry in 1985 from H ull University\, an MSc in Neurochemistry from the Institute of Psychiatry \, London\, in 1986\, and a PhD from Imperial College\, London\, in 1989. From 1989-1992\, he was a post-doctoral Fogarty Visiting Fellow at the NIM H\, USA\, where he developed his interest in the neurobiology and treatmen t of psychiatric disorders. In 1992\, Dr Burnet received an MRC Training F ellowship at the University Department of Psychiatry\, Oxford\, to study t he neuropharmacology of antipsychotics drugs and the pathophysiology of sc hizophrenia. Dr Burnet is now an Associate Professor\, and is currently in vestigating how the augmentation of gut microbial growth with prebiotics i nfluences brain function. \n\n\n\nSpeakers:\nDr Philip Burnet (ASSOCIATE P ROFESSOR AND DIRECTOR OF GRADUATE STUDIES) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/9388d7a2-757b-49ef-a501-4f0fb293b34c/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Probiotic and Prebiotic modulation of Brain Function - Dr Philip Burnet (ASSOCIATE PROFESSOR AND DIRECTOR OF GRADUATE STUDIES) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Novel microscopy approaches for label-free sub-diffraction imaging - Dr Kseniya Korobchevskaya (Istituto Italiano di Tecnologia) DTSTART;VALUE=DATE-TIME:20160622T130000 DTEND;VALUE=DATE-TIME:20160622T140000 UID:https://talks.ox.ac.uk/talks/id/54f5d766-4d3f-4d96-8531-8f693bd01175/ DESCRIPTION:Dr. Kseniya Korobchevskaya has obtained her PhD in the ultrafa st spectroscopy laboratory at the Italian Institute of Technology (IIT). H er PhD work was focused on the design and assembly of pump-probe spectrosc opy setups with different configurations for mono-\, two- or multicolour m easurements. After graduation\, Kseniya continued her work as postdoctoral researcher at IIT in the Nanoscopy group where she worked on the developm ent of label-free near IR pump-probe nanoscope. Besides\, she was also clo sely involved in other projects related to nonlinear microscopy\, such as subtraction microscopy approach for second-harmonic generation imaging of collagen fibers or two-photon spectrofluorimetric characterization of new set of red-emitting proteins. Her main research interests lie in super-res olution microscopy\, nonlinear optics\, and ultrafast laser spectroscopy.\ nSpeakers:\nDr Kseniya Korobchevskaya (Istituto Italiano di Tecnologia) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/54f5d766-4d3f-4d96-8531-8f693bd01175/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Novel microscopy approaches for label-free sub-diffractio n imaging - Dr Kseniya Korobchevskaya (Istituto Italiano di Tecnologia) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Mitochondrial dysfunction and MAVS regulation in lupus: return of the LE cell - Ralph C. Budd\, M.D. (Professor of Medicine and Microbiology & Molecular Genetics) DTSTART;VALUE=DATE-TIME:20160620T120000 DTEND;VALUE=DATE-TIME:20160620T130000 UID:https://talks.ox.ac.uk/talks/id/fb383f6c-090d-4cc1-b7b9-4a0d4476dc41/ DESCRIPTION:Dr. Budd has directed the Immunobiology Program at UVM for the past 20 years\, and more recently the Vermont Center for Immunology and I nfectious Diseases (VCIID) for the past 9 years. He directed the Cell and Molecular Biology Graduate Program for three years\, and has been PI for a T32 Training Grant for Immunology and Infectious Diseases as well as for a P01 Program Project Grant. He is a former Pew scholar in the Biological Sciences\, a member of the Association of American Physicians\, and was a 2009 UVM University Scholar. He has served on numerous NIH study section s\, and chaired five of them. Dr. Budd has mentored 11 graduate students\ , 11 postdoctoral fellows\, and 11 junior faculty\, 5 of whom are now tenu red.\nSpeakers:\nRalph C. Budd\, M.D. (Professor of Medicine and Microbiol ogy & Molecular Genetics) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/fb383f6c-090d-4cc1-b7b9-4a0d4476dc41/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Mitochondrial dysfunction and MAVS regulation in lupus: r eturn of the LE cell - Ralph C. Budd\, M.D. (Professor of Medicine and Mic robiology & Molecular Genetics) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Specificity\, cross-talk and adaptation in Type I Interferon signa ling - Professor Anton Zilman (Department of Physics and Institute for Bio materials and Biomedical Engineering\, University of Toronto) DTSTART;VALUE=DATE-TIME:20160420T140000 DTEND;VALUE=DATE-TIME:20160420T150000 UID:https://talks.ox.ac.uk/talks/id/af789975-e4ef-498f-8de7-ac9720dfc359/ DESCRIPTION:Innate immune system is the first line of defense of higher or ganisms against pathogens. It coordinates the behavior of millions of cell s of multiple types\, achieved through numerous signaling molecules. This talk focuses on the signaling specificity of a major class of signaling mo lecules - Type I Interferons - which are also used therapeutically in the treatment of a number of diseases\, such as Hepatitis C\, multiple scleros is and some cancers. Puzzlingly\, different Interferons act through the sa me cell surface receptor but have different effects on the target cells. T hey also exhibit a strange pattern of temporal cross-talk resulting in a s erious clinical problem - loss of response to Interferon therapy. We combi ned mathematical modeling with quantitative experiments to develop a quant itative model of specificity and adaptation in the Interferon signaling pa thway. The model resolves several experimental puzzles and directly affect s the clinical use of Type I Interferons in treatment of viral hepatitis a nd other diseases.\n\nSpeakers:\nProfessor Anton Zilman (Department of Phy sics and Institute for Biomaterials and Biomedical Engineering\, Universit y of Toronto) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/af789975-e4ef-498f-8de7-ac9720dfc359/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Specificity\, cross-talk and adaptation in Type I Interfe ron signaling - Professor Anton Zilman (Department of Physics and Institut e for Biomaterials and Biomedical Engineering\, University of Toronto) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Dissecting GlcNAc-1-Phosphotransferase Function - the key to under standing lysosomal enzyme trafficking - Stuart Kornfeld (Professor of Medi cine\, Washington University in St Louis ) DTSTART;VALUE=DATE-TIME:20160509T160000 DTEND;VALUE=DATE-TIME:20160509T170000 UID:https://talks.ox.ac.uk/talks/id/4c29c3af-8368-4cba-8457-d173fe4ffd79/ DESCRIPTION:Stuart Kornfeld received his M.D. degree in 1962 from Washing ton University in St. Louis. Following clinical training in Internal Medic ine\, he spent 2 years at the NIH before returning to Washington Universit y where he began his studies in the field of glycobiology. His early work dealt with the structure and biosynthesis of Asn-linked oligosaccharides i n mammalian systems. Most recently his lab has focused on the mannose 6-ph osphate recognition system which mediates the trafficking of newly synthes ized acid hydrolases to lysosomes.\nSpeakers:\nStuart Kornfeld (Professor of Medicine\, Washington University in St Louis ) LOCATION:Richard Doll Building (Lecture Theatre)\, Old Road Campus OX3 7LF TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/4c29c3af-8368-4cba-8457-d173fe4ffd79/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Dissecting GlcNAc-1-Phosphotransferase Function - the key to understanding lysosomal enzyme trafficking - Stuart Kornfeld (Professo r of Medicine\, Washington University in St Louis ) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Immune Reconstitution Inflammatory Syndrome in HIV: from bedside t o bench - Irini Sereti (Chief HIV Pathogenesis Section\, Laboratory of Imm unoregulation\, NIAID/NIH) DTSTART;VALUE=DATE-TIME:20160121T150000Z DTEND;VALUE=DATE-TIME:20160121T160000Z UID:https://talks.ox.ac.uk/talks/id/1d7397f5-1025-4927-a2a2-ec26dede2bd3/ DESCRIPTION:My group studies IRIS\, an aberrant inflammatory response upon initiation of antiretroviral therapy in severely immunosuppressed patient s with HIV\,both in clinic and lab\, trying to identify ways to effectivel y prevent it and treat it.\n\nSpeakers:\nIrini Sereti (Chief HIV Pathogene sis Section\, Laboratory of Immunoregulation\, NIAID/NIH) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/1d7397f5-1025-4927-a2a2-ec26dede2bd3/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Immune Reconstitution Inflammatory Syndrome in HIV: from bedside to bench - Irini Sereti (Chief HIV Pathogenesis Section\, Laborato ry of Immunoregulation\, NIAID/NIH) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:The Regulation of Intestinal Immune Homeostasis in Mice and Men - Dr Arthur Mortha (Postdoctoral Fellow\, Center for Science and Medicine at the Mount Sinai Medical Center ) DTSTART;VALUE=DATE-TIME:20160204T130000Z DTEND;VALUE=DATE-TIME:20160204T140000Z UID:https://talks.ox.ac.uk/talks/id/df8a161b-6678-4fa2-bdc2-3e95415a52e4/ DESCRIPTION:\nSpeakers:\nDr Arthur Mortha (Postdoctoral Fellow\, Center fo r Science and Medicine at the Mount Sinai Medical Center ) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/df8a161b-6678-4fa2-bdc2-3e95415a52e4/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:The Regulation of Intestinal Immune Homeostasis in Mice a nd Men - Dr Arthur Mortha (Postdoctoral Fellow\, Center for Science and Me dicine at the Mount Sinai Medical Center ) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Interferons: Tug of war between host and pathogen - Charlotte Oden dall (Harvard Medical School) DTSTART;VALUE=DATE-TIME:20160119T130000Z DTEND;VALUE=DATE-TIME:20160119T140000Z UID:https://talks.ox.ac.uk/talks/id/c99c8662-39d1-4df3-9574-4cd396e4e7a6/ DESCRIPTION:\nSpeakers:\nCharlotte Odendall (Harvard Medical School) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/c99c8662-39d1-4df3-9574-4cd396e4e7a6/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Interferons: Tug of war between host and pathogen - Charl otte Odendall (Harvard Medical School) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Mechanisms of tumor evasion from NK cell surveillance and potentia l clinical applications - Michele Ardolino (Raulet Laboratory\, University of California\, Berkley) DTSTART;VALUE=DATE-TIME:20160112T120000Z DTEND;VALUE=DATE-TIME:20160112T130000Z UID:https://talks.ox.ac.uk/talks/id/69c16b38-536f-45dc-89b8-96f60de0a8c0/ DESCRIPTION:Natural Killer (NK) cells are a subset of innate lymphocytes t hat play a major role in the immune response against tumors. During my pos t-doctoral training\, I discovered two mechanisms employed by tumor cells to evade NK cell-mediated immune surveillance. \nInitially\, we found that NK cells infiltrating tumors with low expression of MHC class I molecules became functionally anergic. NK cell anergy was associated with impaired signaling downstream of activating receptors and was reverted by treatment with pro-inflammatory cytokines. Notably\, in tumors with anergic NK cell s\, cytokine treatment had an impressive therapeutic effect resulting in i ncreased mouse survival (Ardolino et al.\, JCI\, 2014).\nIn a second study \, we discovered that NK cells in several mouse tumor models expressed the checkpoint inhibitory receptor PD-1. PD-1 inhibited the NK cell response to tumor cells expressing the PD-1 ligand PD-L1. Importantly\, mice treate d with a PD-1 blocking antibody responded dramatically to the treatment\, with the response completely depending on the NK cells (Ardolino et al.\, manuscript in preparation). As PD-1 is a major target of cancer immunother apy\, this discovery is of the outmost importance and provides new insight on the successful outcome of checkpoint blockade.\nDuring the seminar\, I will present key data concerning these two studies. In addition\, I will briefly overview my plan as an independent investigator\, presenting some preliminary data supporting the proposal.\n\nSpeakers:\nMichele Ardolino ( Raulet Laboratory\, University of California\, Berkley) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/69c16b38-536f-45dc-89b8-96f60de0a8c0/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Mechanisms of tumor evasion from NK cell surveillance and potential clinical applications - Michele Ardolino (Raulet Laboratory\, U niversity of California\, Berkley) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Functional plasticity of CD4+ T cells is driven by an asymmetric i nheritance of mitochondria - Prof Stephen Cobbold (University of Oxford) DTSTART;VALUE=DATE-TIME:20160118T120000Z DTEND;VALUE=DATE-TIME:20160118T130000Z UID:https://talks.ox.ac.uk/talks/id/f62623fe-86d8-47ce-ad61-b2c7ed8aeae6/ DESCRIPTION:Steve Cobbold is Professor of Cellular Immunology at the Sir W illiam Dunn School of Pathology\, University of Oxford\, where he continue s to investigate how monoclonal antibodies can be used to therapeutically manipulate the immune system. He studied Biochemistry in Oxford\, followe d by a Ph.D. in Cambridge\, which led to the first demonstrations of toler ance induction to proteins and then organ grafts using CD4 monoclonal anti bodies in adult rodents. As part of the Waldmann group\, he was also activ ely involved in the development of CAMPATH monoclonal antibodies\, which a re now used for the treatment of certain leukemias and for multiple sclero sis. He also developed statistical methods for the analysis of antibody cl usters as used in the 3rd Human CD Antigen Workshop (1987) and in 1993 he organized the first Canine Leukocyte Antigen Workshop (CLAW). He was a sc ientific co-founder of TolerRx Inc.\, and together with Geoff Hale and Pep py Rebello\, he co-founded BioAnaLab Ltd.\, a company that performs contra ct research and diagnostic testing for the biopharmaceutical industry\, wh ich was successfully sold to Merck/Millipore in 2009. He has published mor e than 250 articles and patents on the therapeutic applications of monoclo nal antibodies and the mechanisms of transplantation tolerance. He recentl y suffered end stage renal failure and received a reciprocal paired donati on kidney transplant with CAMPATH induction – perhaps the ultimate in cl inical translation of his work?\nSpeakers:\nProf Stephen Cobbold (Universi ty of Oxford) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/f62623fe-86d8-47ce-ad61-b2c7ed8aeae6/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Functional plasticity of CD4+ T cells is driven by an asy mmetric inheritance of mitochondria - Prof Stephen Cobbold (University of Oxford) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Actin cytoskeletal dynamics underpinning T-cell activation - Dr Ma rco Fritzsche (Group leader at MRC Human Immunology Unit\, Weatherall Ins titute of Molecular Medicine) DTSTART;VALUE=DATE-TIME:20151120T130000Z DTEND;VALUE=DATE-TIME:20151120T140000Z UID:https://talks.ox.ac.uk/talks/id/8aafdacc-7990-4242-8164-3db7beb0c5e4/ DESCRIPTION:\nSpeakers:\nDr Marco Fritzsche (Group leader at MRC Human Imm unology Unit\, Weatherall Institute of Molecular Medicine) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/8aafdacc-7990-4242-8164-3db7beb0c5e4/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Actin cytoskeletal dynamics underpinning T-cell activatio n - Dr Marco Fritzsche (Group leader at MRC Human Immunology Unit\, Weath erall Institute of Molecular Medicine) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Actin cytoskeletal dynamics underpinning T-cell activation - Dr Ma rco Fritzsche (MRC Human Immunology Unit\, Weatherall Institute of Molecul ar Medicine) DTSTART;VALUE=DATE-TIME:20151120T130000Z DTEND;VALUE=DATE-TIME:20151120T140000Z UID:https://talks.ox.ac.uk/talks/id/e7ef3c9b-c717-4e23-a4d7-ef5372cc3e6c/ DESCRIPTION:\nSpeakers:\nDr Marco Fritzsche (MRC Human Immunology Unit\, W eatherall Institute of Molecular Medicine) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/e7ef3c9b-c717-4e23-a4d7-ef5372cc3e6c/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Actin cytoskeletal dynamics underpinning T-cell activatio n - Dr Marco Fritzsche (MRC Human Immunology Unit\, Weatherall Institute o f Molecular Medicine) TRIGGER:-PT1H END:VALARM END:VEVENT BEGIN:VEVENT SUMMARY:Survival of the simplest: how G protein-coupled receptors evolved - Dr James Felce (University of Oxford) DTSTART;VALUE=DATE-TIME:20151203T093000Z DTEND;VALUE=DATE-TIME:20151203T103000Z UID:https://talks.ox.ac.uk/talks/id/f2958851-c37a-4008-b0b2-cb560a467a69/ DESCRIPTION:Dr James Felce did his DPhil with Simon Davis at the WIMM look ing at GPCR behaviour and evolution using biophysical and imaging approach es\, and has stayed with Simon as a post-doc for the last year and a half investigating the structure of the T cell receptor complex.\nSpeakers:\nDr James Felce (University of Oxford) LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Lecture Theatre )\, Headington OX3 7FY TZID:Europe/London URL:https://talks.ox.ac.uk/talks/id/f2958851-c37a-4008-b0b2-cb560a467a69/ BEGIN:VALARM ACTION:display DESCRIPTION:Talk:Survival of the simplest: how G protein-coupled receptors evolved - Dr James Felce (University of Oxford) TRIGGER:-PT1H END:VALARM END:VEVENT END:VCALENDAR