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SUMMARY:Genomic Insights into Herpesviral evolution and pathogenesis - Pro
 fessor Judith Breuer (University College London)
DTSTART;VALUE=DATE-TIME:20190529T120000
DTEND;VALUE=DATE-TIME:20190529T130000
UID:https://talks.ox.ac.uk/talks/id/e311f432-e955-428e-a5b2-421ec4fa79de/
DESCRIPTION:Herpesvirus are ancient pathogens that have co-evolved with th
 eir cognate hosts.  The use of pioneering enrichment methods to sequence h
 erpesvirus genomes directly from clinical material has revealed unexpected
  insights into the evolution and pathogenesis of these DNA viruses .  We f
 ind that recombination is a dominant driver of herpesvirus evolution\, wit
 h herpes simplex and cytomegalovirus recombining freely\, other than in ke
 y hotspots.  In contrast varicella zoster virus and Epstein Barr virus rec
 ombination is constrained leading to evidence of population structure.  Wh
 ile the forces shaping the VZV and EBV population structure are unknown th
 e data suggest possible hypotheses that will be explored. Mathematical mod
 elling of sequence data recovered from clinical samples also provides insi
 ght into the natural history of these human-restricted viruses in their na
 tural host\, leading to new findings and testable hypotheses about pathoge
 nesis and virulence. \nSpeakers:\nProfessor Judith Breuer (University Coll
 ege London)
LOCATION:Medawar Building (Level 30 Seminar room)\, off South Parks Road O
 X1 3SY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/e311f432-e955-428e-a5b2-421ec4fa79de/
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DESCRIPTION:Talk:Genomic Insights into Herpesviral evolution and pathogene
 sis - Professor Judith Breuer (University College London)
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SUMMARY:Whole genome sequencing from clinical material provides insights i
 nto pathogen evolution and disease - Professor Judith Breuer (University C
 ollege London)
DTSTART;VALUE=DATE-TIME:20160210T160000Z
DTEND;VALUE=DATE-TIME:20160210T170000Z
UID:https://talks.ox.ac.uk/talks/id/1d480891-7185-459a-bc35-cfcecbb7c883/
DESCRIPTION:\nStatus: This talk is in preparation - details may change\n\n
 Speakers:\nProfessor Judith Breuer (University College London)
LOCATION:Tinbergen Building (Department of Zoology\, South Parks Road\, Ox
 ford OX1 3PS\, Lecture Theatre B)\, South Parks Road OX1 3PS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/1d480891-7185-459a-bc35-cfcecbb7c883/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Whole genome sequencing from clinical material provides i
 nsights into pathogen evolution and disease - Professor Judith Breuer (Uni
 versity College London)
TRIGGER:-PT1H
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