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SUMMARY:Quantitative Approaches Towards Understanding Multicellular Organi
 sation and Communication - Dr Heba Sailem (University of Oxford)
DTSTART;VALUE=DATE-TIME:20201007T100000
DTEND;VALUE=DATE-TIME:20201007T110000
UID:https://talks.ox.ac.uk/talks/id/f43bb9ec-5221-4475-941b-59745540f754/
DESCRIPTION:Multicellular organisation requires the coordination of multip
 le signalling pathways that regulate cell shape as well as cell-cell and c
 ell-microenvironment interactions. Such coordination is often lost in canc
 er resulting in changes in tissue architecture\, uncontrolled growth\, and
  metastasis.  Imaging technologies provide a powerful approach to simultan
 eously study the signalling and organisational state of cells. I will disc
 uss the development of machine learning and computer vision methodologies 
 for automated identification of genetic programmes underlying tissue organ
 isation. Importantly\, these studies reveal that cell context and shape ca
 n modulate cell signalling even in isogenic cell cultures. Using orthogona
 l datasets and integrative approaches\, we validate the clinical relevance
  of cell shape and context in patient prognosis.\nSpeakers:\nDr Heba Saile
 m (University of Oxford)
LOCATION:Kennedy Institute of Rheumatology (This seminar will be held usin
 g Zoom. Please register here: https://zoom.us/meeting/register/tJUvc-6hrT8
 oGNUvBHRYE_dYudaz8bR0Fa7l )\, Headington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/f43bb9ec-5221-4475-941b-59745540f754/
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DESCRIPTION:Talk:Quantitative Approaches Towards Understanding Multicellul
 ar Organisation and Communication - Dr Heba Sailem (University of Oxford)
TRIGGER:-PT1H
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