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SUMMARY:Mechanobiology of cell migration: mathematical modelling and micro
 fluidics-based experiments go hand-in-hand - Dr Jose Manuel Garcia Aznar (
 University of Zaragoza)
DTSTART;VALUE=DATE-TIME:20190607T140000
DTEND;VALUE=DATE-TIME:20190607T150000
UID:https://talks.ox.ac.uk/talks/id/4ac11a94-a442-4449-9234-b16587084558/
DESCRIPTION:Mechanobiology is a field of science that aims to understand h
 ow mechanics regulate biology. It focuses on how mechanical forces and alt
 erations in mechanical properties of cell or tissues regulate biological p
 rocesses in development\, physiology and disease. In fact\, all these proc
 esses occur in our body\, which presents a clear structural and hierarchic
 al organization that goes from the organism to the cellular level. To adva
 nce in the understanding of all these processes at different scales requir
 es the use of simplified representations of our body\, which is normally k
 nown as modelling or equivalently the creation of a model. Different types
  of models can be found in the literature: in-vitro\, in-vivo and in-silic
 o models. \n\nHere\, I will present our modelling strategy in which we int
 egrate different mathematical models and experiments in order to tackle re
 levant mechanical-based mechanisms in wound healing and cancer metastasis 
 progression [1\,2]. In fact\, we have focused our research on individual [
 3] and collective cell migration [4]\, because it is a crucial event in al
 l these mechanisms. Therefore\, unravelling the intrinsic mechanisms that 
 cells use to define their migration is an essential element for advancing 
 the development of new technologies in regenerative medicine and cancer.\n
 \nDue to the complexity of all these mechanisms\, mathematical modelling i
 s a relevant tool for providing deeper insight and quantitative prediction
 s of the mechanical interplay between cells and extracellular matrix durin
 g cell migration. To assess the predictive capacity of these models\, we w
 ill compare our numerical results with microfluidic-based experiments [2]\
 , which provide experimental information to test and refine the main assum
 ptions of our models. \n\nActually\, we design and fabricate multi-channel
  3D microfluidics cell culture chips\, which allow recreating the physiolo
 gy and disease of one organ or any biological process with a precise contr
 ol of the micro environmental factors [5]. Therefore\, this kind of organ-
 on-a-chip experiments constitutes a novel modelling strategy of in vitro m
 ulticellular human systems that in combination with mathematical simulatio
 ns provide a relevant tool for research in mechanobiology.\n\nReferences\n
 \n1.	Escribano J\, Chen M\, Moeendarbary E\, Cao X\, Shenoy V\, Garcia-Azn
 ar JM\, Kamm RD\, Spill F.  Balance of Mechanical Forces Drives Endothelia
 l Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation. P
 LOS Computational Biology\, in press.\n2.	Merino-Casallo\, F.\, Gomez-Beni
 to\, M. J.\, Juste-Lanas\, Y.\, Martinez-Cantin\, R.\, & Garcia-Aznar\, J.
  M. (2018). Integration of in vitro and in silico models using Bayesian op
 timization with an application to stochastic modeling of mesenchymal 3D ce
 ll migration. Frontiers in physiology\, 9.\n3.	Ribeiro\, F. O.\, Gómez-Be
 nito\, M. J.\, Folgado\, J.\, Fernandes\, P. R.\, & García-Aznar\, J. M. 
 (2017). Computational model of mesenchymal migration in 3D under chemotaxi
 s. Computer methods in Biomechanics and Biomedical engineering\, 20(1)\, 5
 9-74.\n4.	Sunyer\, R.\, Conte\, V.\, Escribano\, J.\, Elosegui-Artola\, A.
 \, Labernadie\, A.\, Valon\, L.\, ... & Trepat\, X. (2016). Collective cel
 l durotaxis emerges from long-range intercellular force transmission. Scie
 nce\, 353(6304)\, 1157-1161.\n5.	Plou\, J.\, Juste-Lanas\, Y.\, Olivares\,
  V.\, Del Amo\, C.\, Borau\, C.\, & García-Aznar\, J. M. (2018). From ind
 ividual to collective 3D cancer dissemination: roles of collagen concentra
 tion and TGF-β. Scientific reports\, 8(1)\, 12723.\n\nSpeakers:\nDr Jose 
 Manuel Garcia Aznar (University of Zaragoza)
LOCATION:Mathematical Institute (L3)\, Woodstock Road OX2 6GG
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/4ac11a94-a442-4449-9234-b16587084558/
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DESCRIPTION:Talk:Mechanobiology of cell migration: mathematical modelling 
 and microfluidics-based experiments go hand-in-hand - Dr Jose Manuel Garci
 a Aznar (University of Zaragoza)
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