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VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:From Single Cells and Columns to Cortical Networks: Coincidence De
 tection and Synaptic Transmission - Professor Bert Sakmann (Max Planck Ins
 titute of Neurobiology)
DTSTART;VALUE=DATE-TIME:20161117T120000Z
DTEND;VALUE=DATE-TIME:20161117T130000Z
UID:https://talks.ox.ac.uk/talks/id/408ba36f-8776-4a56-8ea1-7090addaada7/
DESCRIPTION:While patch pipettes were initially designed to record element
 ary current events\, the whole-cell and cell-attached recording configurat
 ions proved useful tools also for examining signaling within and between n
 eurons. I will first summarize work on electrical signaling within single 
 neurons\, describing communication between their dendritic compartments\, 
 soma\, and nerve terminals via forward and backward propagating action pot
 entials. Dendritic excitability endows neurons with a capacity for coincid
 ence detection of spatially separated subthreshold inputs\, which is broad
 cast to other cells by the initiation of action potential bursts (AP burst
 s). AP bursts can trigger target cell-specific release mechanisms at diffe
 rent terminals of the same neuron and result in the induction of synaptic 
 plasticity if pre- and postsynaptic AP bursts coincide. But what are the r
 oles of active dendritic excitability in behaving animals? To answer this 
 question\, I will highlight the functional architecture of an averaged cor
 tical column in the vibrissal (whisker) field of somatosensory cortex (vS1
 ) and compare synaptic and unit responses of major cortical output neurons
  in layer 5 with responses of afferent neurons in primary somatosensory th
 alamus and one efferent target. The occurrence of AP bursts suggests that 
 coincidence detection mechanisms operate in vivo\; three-dimensional recon
 structions indicate that combinations of thalamocortical and intra-columna
 r inputs could activate dendritic coincidence detection mechanisms. Record
 ings from efferent targets reveal the importance of AP bursts for signal t
 ransfer to these cells. vS1 cortex thus appears to transform the afferent 
 sensory code\, at least partially\, from a rate to an interval (burst) cod
 e.\n\nBert Sakmann shared the 1991 Nobel Prize in Physiology or Medicine "
 for discoveries concerning the function of single ion channels in cells."\
 nSpeakers:\nProfessor Bert Sakmann (Max Planck Institute of Neurobiology)
LOCATION:The Oxford Martin School
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/408ba36f-8776-4a56-8ea1-7090addaada7/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:From Single Cells and Columns to Cortical Networks: Coinc
 idence Detection and Synaptic Transmission - Professor Bert Sakmann (Max P
 lanck Institute of Neurobiology)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:From Single Cells and Columns to Cortical Networks: Coincidence De
 tection and Synaptic Transmission  - Professor Bert Sakmann (Max Planck In
 stitute of Neurobiology)
DTSTART;VALUE=DATE-TIME:20161117T120000Z
DTEND;VALUE=DATE-TIME:20161117T130000Z
UID:https://talks.ox.ac.uk/talks/id/ef2e4ada-3690-4dc3-916d-1fab72da189a/
DESCRIPTION:While patch pipettes were initially designed to record element
 ary current events\, the whole-cell and cell-attached recording configurat
 ions proved useful tools also for examining signaling within and between n
 eurons. I will first summarize work on electrical signaling within single 
 neurons\, describing communication between their dendritic compartments\, 
 soma\, and nerve terminals via forward and backward propagating action pot
 entials. Dendritic excitability endows neurons with a capacity for coincid
 ence detection of spatially separated subthreshold inputs\, which is broad
 cast to other cells by the initiation of action potential bursts (AP burst
 s). AP bursts can trigger target cell-specific release mechanisms at diffe
 rent terminals of the same neuron and result in the induction of synaptic 
 plasticity if pre- and postsynaptic AP bursts coincide. But what are the r
 oles of active dendritic excitability in behaving animals? To answer this 
 question\, I will highlight the functional architecture of an averaged cor
 tical column in the vibrissal (whisker) field of somatosensory cortex (vS1
 ) and compare synaptic and unit responses of major cortical output neurons
  in layer 5 with responses of afferent neurons in primary somatosensory th
 alamus and one efferent target. The occurrence of AP bursts suggests that 
 coincidence detection mechanisms operate in vivo\; three-dimensional recon
 structions indicate that combinations of thalamocortical and intra-columna
 r inputs could activate dendritic coincidence detection mechanisms. Record
 ings from efferent targets reveal the importance of AP bursts for signal t
 ransfer to these cells. vS1 cortex thus appears to transform the afferent 
 sensory code\, at least partially\, from a rate to an interval (burst) cod
 e.\nSpeakers:\nProfessor Bert Sakmann (Max Planck Institute of Neurobiolog
 y)
LOCATION:Oxford Martin School\, 34 Broad Street
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/ef2e4ada-3690-4dc3-916d-1fab72da189a/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:From Single Cells and Columns to Cortical Networks: Coinc
 idence Detection and Synaptic Transmission  - Professor Bert Sakmann (Max 
 Planck Institute of Neurobiology)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR