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SUMMARY:"Systems analysis of inflammation"   AND   "Oxford - Berlin Partne
 rship: joined forces for excellent research in and beyond rheumatology" - 
 Prof Eicke Latz (German Rheumatology Research Center (DRFZ))\, Ms Uta Biel
 feldt (German Rheumatology Research Center (DRFZ))
DTSTART;VALUE=DATE-TIME:20240605T120000
DTEND;VALUE=DATE-TIME:20240605T133000
UID:https://talks.ox.ac.uk/talks/id/61efc507-a152-4fa9-aa00-4e93407f8fd2/
DESCRIPTION:Chronic low-grade inflammation\, also called metaflammation\, 
 is associated with prevalent non-communicable diseases. Anti-inflammatory 
 therapy provides a clinical benefit in patients\, but the triggers that in
 cite metaflammation remain largely unknown. To uncover non-genetic inflamm
 atory factors influencing Western-diet mediated inflammation and pathology
 \, we performed an unbiased in vivo screen measuring thousands of host- an
 d microbe-derived molecules in a mouse model of atherosclerosis. Machine l
 earning-supported analyses identified\, next to known pro- and anti-athero
 genic factors\, the medium fatty acid-chain sphingomyelin d18:1/14:0 (S14)
  as highly positively associated with atherogenesis. S14 activated macroph
 age innate immune signalling\, immune-metabolic reprogramming and pro-infl
 ammatory gene transcription. The inflammatory activity of S14 was TLR4- an
 d MD-2-dependent\, consistent with biochemical and molecular dynamics simu
 lation analyses showing that S14 promoted the formation of active TLR4/MD-
 2 dimers. Human interventional and observational trials demonstrated that 
 dietary changes altered concentrations of S14 and that increased circulati
 ng S14 was associated with carotid plaque development in obese individuals
 . Collectively\, these findings identify an inducible endogenous ligand fo
 r TLR4 that drives metaflammation\, providing the rationale for preventati
 ve approaches and pharmacological interventions that may curb detrimental 
 inflammation secondary to Western-type lifestyle habits. \n\n\nAND\n\nThe 
 Oxford-Berlin Partnership is an academic partnership between the Universit
 y of Oxford and the Berlin University Alliance. KIR and DRFZ are embedded 
 in this unique setting supporting a variety of possible academic activitie
 s in both Oxford & Berlin\, including seed-funding\, mobility calls and sy
 mposia. The possibility of submitting joint applications to third-party fu
 nders (e.g. Horizon Europe)could promote the rheumatological research at b
 oth locations.\nSpeakers:\nProf Eicke Latz (German Rheumatology Research C
 enter (DRFZ))\, Ms Uta Bielfeldt (German Rheumatology Research Center (DRF
 Z))
LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea
 dington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/61efc507-a152-4fa9-aa00-4e93407f8fd2/
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DESCRIPTION:Talk:"Systems analysis of inflammation"   AND   "Oxford - Berl
 in Partnership: joined forces for excellent research in and beyond rheumat
 ology" - Prof Eicke Latz (German Rheumatology Research Center (DRFZ))\, Ms
  Uta Bielfeldt (German Rheumatology Research Center (DRFZ))
TRIGGER:-PT1H
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