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SUMMARY:The Hippo pathway in cell growth\, organ size\, and Tumorigenesis 
  - Professor Kun-Liang Guan (UCSD)
DTSTART;VALUE=DATE-TIME:20180620T110000
DTEND;VALUE=DATE-TIME:20180620T120000
UID:https://talks.ox.ac.uk/talks/id/06a1944d-dbf9-4c01-9bb4-480b0d68d390/
DESCRIPTION:The Hippo pathway is crucial in organ size control and its dys
 regulation contributes to tumorigenesis.  Core components of the Hippo pat
 hway include the protein kinases of MST1/2\, MAP4Ks\, LATS1/2\, the transc
 ription co-activators YAP/TAZ and their DNA binding partners TEADs. LATS p
 hosphorylates YAP/TAZ to promote cytoplasmic localization and degradation\
 , thereby inhibiting YAP/TAZ and cell growth. The Hippo pathway is regulat
 ed by a wide range of signals\, including cell density\, GPCR\, cellular e
 nergy levels\, and mechanical cues. We recently discovered that TEAD shutt
 les to cytoplasm in a Hippo independent manner. Moreover\, the Hippo pathw
 ay also plays a critical role in suppressing cancer immunity. The emerging
  role of the Hippo pathway in tumorigenesis suggests potential therapeutic
  value of targeting this pathway for cancer treatment.\nSpeakers:\nProfess
 or Kun-Liang Guan (UCSD)
LOCATION:NDM Building (Basement seminar room\, TDI)\, Headington OX3 7FZ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/06a1944d-dbf9-4c01-9bb4-480b0d68d390/
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DESCRIPTION:Talk:The Hippo pathway in cell growth\, organ size\, and Tumor
 igenesis  - Professor Kun-Liang Guan (UCSD)
TRIGGER:-PT1H
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