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SUMMARY:Hallucinating mice\, neural circuits and immunity – towards mech
 anistic treatments for psychosis - Dr Katharina Schmack (Francis Crick Ins
 titute and University College London)
DTSTART;VALUE=DATE-TIME:20260128T150000Z
DTEND;VALUE=DATE-TIME:20260128T160000Z
UID:https://talks.ox.ac.uk/talks/id/0495302f-bf7b-4d89-91c8-0800aad839c7/
DESCRIPTION:Psychosis is a core feature of severe mental illness\, yet its
  biological basis remains poorly understood. This talk presents a cross-sp
 ecies research programme combining behavioural paradigms\, computational m
 odelling\, circuit neuroscience and immunology to identify mechanistic tre
 atment targets. We developed a paradigm to measure hallucination-like perc
 eption in both humans and mice\, revealing key roles for dopamine and acet
 ylcholine. We also established a novel mouse model of autoimmune psychosis
 \, showing how brain-reactive antibodies can disrupt circuits and behaviou
 r and how antipsychotic drugs modulate autoimmune processes. Ongoing work 
 in humans and mice investigates how neural and immune mechanisms interact 
 to drive psychosis and shape perception.\nSpeakers:\nDr Katharina Schmack 
 (Francis Crick Institute and University College London)
LOCATION:BNDU Mansfield Road\, Pharmacology Lecture Theatre
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/0495302f-bf7b-4d89-91c8-0800aad839c7/
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DESCRIPTION:Talk:Hallucinating mice\, neural circuits and immunity – tow
 ards mechanistic treatments for psychosis - Dr Katharina Schmack (Francis 
 Crick Institute and University College London)
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