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SUMMARY:"Optimizing the efficacy of metal-based MRI probes at high magneti
 c fields" - Professor Mauro Botta (Università del Piemonte Orientale)
DTSTART;VALUE=DATE-TIME:20171024T140000
DTEND;VALUE=DATE-TIME:20171024T150000
UID:https://talks.ox.ac.uk/talks/id/09741a9b-d85a-4f4c-880b-44dca6bf28d9/
DESCRIPTION:Optimizing the efficacy of Gd-based MRI probes at high magneti
 c fields \n\n\nGdIII complexes are in current clinical use as MRI contrast
  agents. Their ability to enhance the MR image is termed relaxivity and it
  depends upon many molecular factors\, including speciation\, protein bind
 ing affinity\, chemical structure\, and dynamic processes\, such as water 
 exchange kinetics and rotational tumbling rates. A significant portion of 
 research in the field of contrast agent development is devoted to controll
 ing the relaxivity (efficiency) of GdIII complexes. The structure of the c
 helate determines the interaction between the ion and the surrounding wate
 r molecules\, and consequently the relaxivity of the complex. However\, cl
 inically used Gd-based contrast agents are low molecular weight\, rapidly 
 tumbling complexes with limited efficacy (relaxivity\, r1) that decreases 
 with the magnetic field strength. The enhancement of the efficiency of the
  probe is based on the structural modification of the clinical complexes\,
  guided by a detailed understanding of the relationship between the relaxa
 tion parameters and the chemical structure. \nMoreover\, MRI is increasing
 ly moving to higher fields as the majority of the scanners used in clinics
  operate at 1.5 - 3 T. Therefore\, it is important to develop new T1 agent
 s characterized by enhanced relaxivity over a broad range of imaging field
  strengths for use with current scanners. Multimeric GdIII agents with int
 ermediate molecular weight (~2-6 kDa) have been proposed as a possible sol
 ution. The purpose of this seminar is to discuss recent results in the sea
 rch for relaxivity enhancement at magnetic field strengths ≥ 1.5 T.\n\nS
 peakers:\nProfessor Mauro Botta (Università del Piemonte Orientale)
LOCATION:Inorganic Chemistry Laboratory (Lecture Theatre of the Inorganic 
 Chemistry Laboratory)\, South Parks Road OX1 3QR
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/09741a9b-d85a-4f4c-880b-44dca6bf28d9/
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DESCRIPTION:Talk:"Optimizing the efficacy of metal-based MRI probes at hig
 h magnetic fields" - Professor Mauro Botta (Università del Piemonte Orien
 tale)
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