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SUMMARY:Engineering human stem cells for muscle disease modelling and ther
 apy development - Prof. Francesco Saverio Tedesco (University College Lond
 on)
DTSTART;VALUE=DATE-TIME:20211013T140000
DTEND;VALUE=DATE-TIME:20211013T150000
UID:https://talks.ox.ac.uk/talks/id/12775dcf-493b-45ca-9e56-789579cfd902/
DESCRIPTION:Skeletal muscle is the most abundant human tissue. It has a co
 mplex structure and some regenerative capacity\, supported by a pool of mu
 scle stem cells. Numerous\, severe genetic diseases impair skeletal muscle
  function and regenerative capacity\, with the vast majority of them still
  remaining incurable. Our laboratory (www.tedescolab.org) studies skeletal
  muscle regeneration\, focusing on the development of novel therapies for 
 incurable neuromuscular disorders of childhood. Our work pioneered the use
  of human artificial chromosomes and induced pluripotent stem (iPS) cells 
 for gene and cell therapies of muscular dystrophies. Recently\, we develop
 ed the first 3D artificial skeletal muscle entirely derived from patient-s
 pecific induced pluripotent stem (iPS) cells\, and we showed that it can m
 odel severe forms of muscular dystrophy with high fidelity and resolution.
  Current projects focus on generating advanced human in vitro models of ne
 uromuscular diseases for therapy development\, as well as on using small m
 olecules to improve human muscle stem cell delivery to target tissues. Dur
 ing my talk I will recap and review significant achievements of our previo
 us work\, and present new unpublished results on advanced human neuromuscu
 lar disease modelling and stem cell engineering for muscle gene and cell t
 herapy.\nSpeakers:\nProf. Francesco Saverio Tedesco (University College Lo
 ndon)
LOCATION:Online Zoom seminar
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/12775dcf-493b-45ca-9e56-789579cfd902/
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DESCRIPTION:Talk:Engineering human stem cells for muscle disease modelling
  and therapy development - Prof. Francesco Saverio Tedesco (University Col
 lege London)
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