BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:The Role of TL1A/DR3 in Intestinal Inflammation  - Dr Fabio Comine
 lli (Professor\, Departments of Medicine and Pathology\, Director of the C
 WRU/UH Digestive Health Centre\, USA)
DTSTART;VALUE=DATE-TIME:20160120T133000Z
DTEND;VALUE=DATE-TIME:20160120T143000Z
UID:https://talks.ox.ac.uk/talks/id/15812356-63b9-4f27-878b-dc506908790a/
DESCRIPTION:Biography \nFabio Cominelli\, MD\, PhD\, is Professor of Medic
 ine and Pathology\, Chief of the Division of Gastroenterology and Liver Di
 sease\, and Director of the Digestive Health Research Institute at Case We
 stern Reserve University (CWRU) and University Hospitals of Cleveland.  He
  is also the inaugural awardee of the Hermann Menges Jr Chair in Internal 
 Medicine and Associate Dean for Program Development.  Dr. Cominelli is the
  Principal Investigator (PI) and Director of a National Institutes of Heal
 th (NIH) Program Project Grant\, studying the role of innate immunity in e
 xperimental Crohn’s disease\, and two R01 grants focused on the role of 
 cytokines and commensal flora in the pathogenesis of intestinal inflammati
 on.  He is also the PI of a T32 Training grant in Digestive Disease Scienc
 es at CWRU\, as well as the PI and Director of the Cleveland NIH Digestive
  Diseases Research Core Center. \nHis research interest in the area of exp
 erimental inflammatory bowel disease and intestinal cytokines dates back 2
 8 years to his fellowship in Gastroenterology research under Dr. Robert Zi
 pser at Harbor UCLA Medical Center.  These two general areas of research h
 ave remained the focus of his investigation ever since.  In recognition of
  his research accomplishments\, Dr. Cominelli was the recipient of the 200
 2 Outstanding Investigator Award from the American Federation for Medical 
 Research for his studies establishing that targeted neutralization of a sp
 ecific cytokine was effective for the treatment of experimental IBD.  Dr. 
 Cominelli has over 25 years of experience and continuous NIH funding in cy
 tokine biology and many seminal discoveries in this field of investigation
 .  His group was the first to report that specific blockade of a single pr
 o-inflammatory cytokine\, i.e. interleukin-1 (IL-1)\, was effective in red
 ucing disease severity in an animal model of experimentally-induced coliti
 s and that an imbalance between intestinal pro- and anti-inflammatory cyto
 kines represents a pathogenic mechanism of auto-inflammatory diseases\, in
 cluding IBD. This concept has now gained considerable attention through re
 ports of severe inflammatory disease in infants with homozygous germ-line 
 mutations in the IL-1 gene family.  These and other studies have formed th
 e foundation for clinical trials using anti-cytokine therapy (e.g. anti-TN
 Fα therapy) as well as administration of anti-inflammatory cytokines\, (e
 .g. IL-1 receptor antagonist) in patients with auto-inflammatory diseases.
  Dr. Cominelli has published more than 150 articles and has extensive expe
 rience as a journal reviewer.  He has been an Associate Editor and an Edit
 orial Board Member for several Journals including the Journal of Immunolog
 y\, Gastroenterology\, Digestive and Liver Disease\, The American Journal 
 of Physiology and others.  He is currently an Academic Editor for PLoS One
  and Associate Editor for Translational Research.  Dr. Cominelli has been 
 also an outstanding mentor and has trained more than 120 individuals many 
 of them being independent investigators or academic leaders in Gastroenter
 ology. \n \nDr. Cominelli is also a highly respected clinician with strong
  expertise in clinical program development for the diagnosis and treatment
  of patients with digestive diseases.  He has been named “American Top D
 octor” in Gastroenterology by Castle Connonly Medical Ltd (2001-2016)\, 
 “Best Doctor” in Gastroenterology\, by the Cleveland Magazine (2009-20
 16)\, “Best Doctor in Gastroenterology (top 1%)”\, by US News & World 
 Report (2012-2016) and “Super Doctor in Gastroenterology” by Key Profe
 ssional Media (2012-2016).\n\n\nSpeakers:\nDr Fabio Cominelli (Professor\,
  Departments of Medicine and Pathology\, Director of the CWRU/UH Digestive
  Health Centre\, USA)
LOCATION:Lecture Theatre 1\, Academic Corridor\, Level 3\, John Radcliffe 
 Hospital
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/15812356-63b9-4f27-878b-dc506908790a/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:The Role of TL1A/DR3 in Intestinal Inflammation  - Dr Fab
 io Cominelli (Professor\, Departments of Medicine and Pathology\, Director
  of the CWRU/UH Digestive Health Centre\, USA)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR