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SUMMARY:Breaking the Silence: How Transcriptional Surveillance by HUSH Gua
 rds the Genome from Reverse Genetic Flow - Professor Paul Lehner (Cambridg
 e Institute of Therapeutic Immunology and Infectious Disease\, University 
 of Cambridge)
DTSTART;VALUE=DATE-TIME:20260129T120000Z
DTEND;VALUE=DATE-TIME:20260129T130000Z
UID:https://talks.ox.ac.uk/talks/id/1ae6fb04-7ca3-47c7-a3ec-30fdeb7f4d19/
DESCRIPTION:Retrotransposition — the reverse flow of genetic information
  from RNA to DNA is the major route by which new genetic material enters o
 ur genome\, with retroelements comprising over 40% of human DNA. This proc
 ess drives innovation but threatens genome integrity\, demanding precise r
 egulation. Our discovery of the Human Silencing Hub (HUSH) revealed a geno
 me-wide transcriptional immunosurveillance system that detects and epigene
 tically silences invading DNA. How HUSH distinguishes self from invading D
 NA was unclear. We found that HUSH discriminates ‘self’ from ‘non-se
 lf’ based on introns: The majority of cellular genes are intron-containi
 ng\, while RNA-derived retroelements are intronless\, marking their cDNA a
 s foreign. This intron-based recognition mechanism uncovers an unexpected 
 innate immune surveillance system that protects the genome from the revers
 e flow of genetic information.\nSpeakers:\nProfessor Paul Lehner (Cambridg
 e Institute of Therapeutic Immunology and Infectious Disease\, University 
 of Cambridge)
LOCATION:MRC Weatherall Institute of Molecular Medicine (se)\, Headington 
 OX3 9DS
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/1ae6fb04-7ca3-47c7-a3ec-30fdeb7f4d19/
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DESCRIPTION:Talk:Breaking the Silence: How Transcriptional Surveillance by
  HUSH Guards the Genome from Reverse Genetic Flow - Professor Paul Lehner 
 (Cambridge Institute of Therapeutic Immunology and Infectious Disease\, Un
 iversity of Cambridge)
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