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PRODID:talks.ox.ac.uk
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SUMMARY:The role of the cardiac lymphatics in heart repair and regeneratio
 n - Prof Paul Riley (Institute of Developmental and Regenerative Medicine\
 , University of Oxford)
DTSTART;VALUE=DATE-TIME:20250721T120000
DTEND;VALUE=DATE-TIME:20250721T130000
UID:https://talks.ox.ac.uk/talks/id/201fb5aa-80a1-4dfe-a1bf-035168649b6e/
DESCRIPTION:Heart attack or myocardial infarction (MI) triggers an immune 
 response\, whereby phagocytic cells remove dead tissue and assist with sub
 sequent repair. High load and persistence of immune cells\, however\, cont
 ributes to further fibrosis\, pathological remodelling and ultimately prog
 ression to heart failure. \nWe have shown that the adult cardiac lymphatic
 s traffic macrophages to draining mediastinal lymph nodes post-MI\, to eff
 ect optimal repair and improve function. We are currently investigating wh
 ich subsets of cleared macrophages correlate with improved outcome.  We ha
 ve further investigated their role across the regenerative window in neona
 tal mice (post-natal days 1-7\; P1-P7).  Normal lymphatic growth and sprou
 ting is evident in intact neonatal hearts until P16\, which coincides with
  a transition in lymphatic endothelial cell junctions from “zipper” (i
 mpermeable) to “button”-type (permeable) junctions. Moreover\, the res
 ponse to injury is significantly altered\, with decreased lymphangiogenesi
 s and minimal clearance of macrophages in P1 compared to P7 mice\, 7-days 
 post-MI\, consistent with the need to maintain a pro-regenerative populati
 on of macrophages in the P1 injured heart.  To gain molecular insight into
  potentially altered lymphatic endothelium-macrophage interactions across 
 this period\, we have generated unbiased scRNA-Seq datasets from P1 versus
  P7 infarcted hearts and observe significant differences in cellular cross
 -talk.  Finally\, in mice lacking lymphatic endothelial receptor-1 (Lyve1)
 \, that exhibit impaired macrophage trafficking\, we surprisingly observed
  impaired functional outcome in P1 mice 28-days post-MI. This suggests a d
 istinct role for Lyve-1 in tissue resident macrophages during neonatal hea
 rt regeneration. \nFurther mechanistic studies may provide therapeutic ins
 ights into immunomodulation of the adult infarcted heart.\nSpeakers:\nProf
  Paul Riley (Institute of Developmental and Regenerative Medicine\, Univer
 sity of Oxford)
LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea
 dington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/201fb5aa-80a1-4dfe-a1bf-035168649b6e/
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DESCRIPTION:Talk:The role of the cardiac lymphatics in heart repair and re
 generation - Prof Paul Riley (Institute of Developmental and Regenerative 
 Medicine\, University of Oxford)
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