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SUMMARY:Self-generated chemotaxis of heterogeneous cell populations - Dr M
 ehmet Can Uçar (University of Sheffield)
DTSTART;VALUE=DATE-TIME:20251114T110000Z
DTEND;VALUE=DATE-TIME:20251114T120000Z
UID:https://talks.ox.ac.uk/talks/id/20b98782-d24f-4d04-ba68-7e56ae8b255a/
DESCRIPTION:Cell and tissue movement during development\, immune response\
 , and cancer invasion depends on chemical or mechanical guidance cues. In 
 many systems\, this guidance arises not from long-range\, pre-patterned cu
 es but from self-generated gradients locally shaped by cells. However\, ho
 w heterogeneous cell mixtures coordinate their migration by self-generated
  gradients remains largely unexplored. In this talk\, I will first summari
 ze our recent discovery that immune cells steer their long-range migration
  using self-generated chemotactic cues (Alanko et al.\, 2023). I will then
  introduce a multi-component Keller-Segel model that describes migration a
 nd patterning strategies of heterogeneous cell populations (Ucar et al.\, 
 2025). Our model predicts that the relative chemotactic sensitivities of d
 ifferent cell populations determine the shape and speed of traveling densi
 ty waves\, while boundary conditions such as external cell and attractant 
 reservoirs substantially influence the migration dynamics. We quantitative
 ly corroborate these predictions with in vitro experiments on co-migrating
  immune cell mixtures. Interestingly\, immune cell co-migration occurs nea
 r the optimal parameter regime predicted by theory for coupled and colocal
 ized migration. Finally\, I will discuss the role of mechanical interactio
 ns\, revealing a non-trivial interplay between chemotactic and mechanical 
 non-reciprocity in driving collective migration.\n\nSpeakers:\nDr Mehmet C
 an Uçar (University of Sheffield)
LOCATION:Mathematical Institute (L4)\, Woodstock Road OX2 6GG
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/20b98782-d24f-4d04-ba68-7e56ae8b255a/
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DESCRIPTION:Talk:Self-generated chemotaxis of heterogeneous cell populatio
 ns - Dr Mehmet Can Uçar (University of Sheffield)
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