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SUMMARY:Sugars & Proteins - Prof Ben Davis (Rosalind Franklin Institute)
DTSTART;VALUE=DATE-TIME:20240529T130000
DTEND;VALUE=DATE-TIME:20240529T140000
UID:https://talks.ox.ac.uk/talks/id/24c00ab7-4910-427e-89f4-09ce606bc4db/
DESCRIPTION:Our work studies the interplay of biomolecules – proteins\, 
 sugars\, lipids and their modifications.\nSynthetic Biology’s developmen
 t at the start of this century may be compared with Synthetic\nOrganic Che
 mistry’s expansion at the start of the last\; after decades of isolation
 \, identification\,\nanalysis and functional confirmation\, the future log
 ical and free-ranging redesign of biomacromolecules\noffers tantalizing op
 portunities to dissect mechanism and control function in physiology\nand b
 iology.\nThis lecture will cover past and emerging areas in our group in t
 he manipulation of biomolecules\nwith an emphasis on new bond-forming and 
 bond-breaking processes compatible with biology\nand using those to unders
 tand molecular mechanisms.\n:\n(i) New methods: the development of precise
  methods that may be applied to biology at a posttranslational\nlevel\, ge
 nerating minimal ‘scars’ or ‘traces’ (ideally ‘trace’-less)\, 
 could allow broad\ncontrol of function. This will allow applications beyon
 d simple ‘labeling biology’ or retrieval biology’.\nThe development 
 of chemo- and regio-selective methods with potential to posttranslationall
 y\n‘edit’ biology in this way\, applied under benign conditions to red
 esign and reprogramme\nthe structure and function of biomolecules\, will b
 e presented.\n(ii) ‘Synthetic Biologics’ and their applications: biomi
 micry\; functional recapitulation\; effector\n[drug/agrochemical/gene/radi
 o-dose] delivery\; selective protein degradation\; inhibitors of pathogen\
 ninteractions\; non-invasive presymptopmatic disease diagnosis\; probes an
 d modulators of in\nvitro and in vivo function illustrate possible resulti
 ng technologies.\nSpeakers:\nProf Ben Davis (Rosalind Franklin Institute)
LOCATION:NDM Building (Basement Seminar Room)\, Headington OX3 7FZ
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/24c00ab7-4910-427e-89f4-09ce606bc4db/
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DESCRIPTION:Talk:Sugars & Proteins - Prof Ben Davis (Rosalind Franklin Ins
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