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SUMMARY:On the network influence of single interneurons from development i
 nto adulthood - Dr Rosa Cossart\, INMED\, INSERM (Aix-Marseille University
 )
DTSTART;VALUE=DATE-TIME:20221125T130000Z
DTEND;VALUE=DATE-TIME:20221125T140000Z
UID:https://talks.ox.ac.uk/talks/id/29daf4ce-c71f-452b-ab7f-829fb32ad91e/
DESCRIPTION:GABAergic interneurons shape the spatial and functional organi
 zation of cortical networks. While many studies have elucidated the physio
 logy and connectivity of single interneurons\, the spatiotemporal relation
 ship of the activity of groups of interneurons and its relation to populat
 ion dynamics remain unclear. In order to untangle how  interneurons intera
 ct with each other and probe their influence on the spatio-temporal organi
 zation of cortical dynamics\, we have used an all-optical approach combini
 ng two-photon calcium imaging with computer-generated holographic light st
 imulation of soma-targeted opsins in awake mice during development and int
 o adulthood. Similar experiments have so far focused on probing the impact
  of functionally tuned glutamatergic neurons  of the visual cortex (Chetti
 h 2019). In this talk\, I will present data indicating that they single-ha
 ndedly exert a significant modulation on the activity of their functional 
 partners\, both in the adult and developing cortex. \n\nSPEAKER BIOGRAPHY\
 n\nRosa Cossart is the Director of the Institute of Mediterranean Neurobio
 logy (INMED)\, affiliated to INSERM and Aix-Marseille University\, a pione
 ering Institute in the field of Systems Developmental Neuroscience.  After
  graduating in Mathematics and Physics from the Ecole Centrale Paris\, she
  studied the functional rewiring of GABAergic circuits in epilepsy during 
 her PhD with Drs. Bernard and Ben-Ari. As a postdoctoral fellow with Pr. Y
 uste at Columbia University\, she pioneered the use of calcium imaging to 
 study cortical circuit function. Her lab made seminal contributions to the
  understanding of how development scaffolds hippocampal circuits.  They di
 scovered “hub cells” and more recently “assemblies” forming the fu
 nctional building blocks of hippocampal function. \nSpeakers:\nDr Rosa Cos
 sart\, INMED\, INSERM (Aix-Marseille University)
LOCATION:Sherrington Building (Blakemore Lecture Theatre)\, off Parks Road
  OX1 3PT
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/29daf4ce-c71f-452b-ab7f-829fb32ad91e/
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DESCRIPTION:Talk:On the network influence of single interneurons from deve
 lopment into adulthood - Dr Rosa Cossart\, INMED\, INSERM (Aix-Marseille U
 niversity)
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