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SUMMARY:MAIT cells in host-microbiota interactions - Dr Francois Legoux (I
 nstitut Curie)
DTSTART;VALUE=DATE-TIME:20260130T120000Z
DTEND;VALUE=DATE-TIME:20260130T130000Z
UID:https://talks.ox.ac.uk/talks/id/2b14d276-8a80-4ee0-b5ee-b75195e35e79/
DESCRIPTION:The emergence of the MHC I-like gene MR1 in the ancestor of ma
 mmals enabled T cells to see new ligands: small metabolites derived either
  from bile acids or from the microbial riboflavin pathway. MR1 remained hi
 ghly conserved and monomorphic during evolution\, and MR1-restricted T cel
 ls (MAIT cells) retained an innate-like program shared across species\, in
 dicating non-redundant functions linked to this antigenic specificity. Our
  lab investigates how MAIT ligands\, which are constantly produced by the 
 microbiota\, shape MAIT cell development and function.\nSpeakers:\nDr Fran
 cois Legoux (Institut Curie)
LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea
 dington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/2b14d276-8a80-4ee0-b5ee-b75195e35e79/
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DESCRIPTION:Talk:MAIT cells in host-microbiota interactions - Dr Francois 
 Legoux (Institut Curie)
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