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SUMMARY:Informing shigellosis control and management in resource poor sett
 ings through pathogen genomics  - Dr Kate Baker (University of Liverpool)
DTSTART;VALUE=DATE-TIME:20210202T140000Z
DTEND;VALUE=DATE-TIME:20210202T150000Z
UID:https://talks.ox.ac.uk/talks/id/2cbcccab-9d99-4d19-b29f-f10a456f3f82/
DESCRIPTION:The Global Enteric Multicentre Study (GEMS) was a case-control
  study that identified Shigella as a leading causes of moderate-to-severe 
 diarrhoea in children under the age of 5 years old in sub-Saharan Africa a
 nd Asia\, yet Shigella is increasingly resistant to antimicrobials\, and t
 here is no licensed vaccine. Here\, we performed large-scale analysis of a
 pproximately 1500 Shigella from GEMS to determine the genomic and genetic 
 diversity among this relevant\, systematically obtained isolate collection
  to draw out implications for management of the disease with antimicrobial
 s as well as prevention through vaccination. We find differences among the
  diversity between Shigella species and collection sites\, including varia
 tion in the epitope region of protein antigen vaccine targets and serotype
  switching events that will affect glycoconjugate vaccination approaches. 
 We also identify significant differences between species and site with reg
 ard to the development of antimicrobial resistance and\, finally\, in cond
 ucting a pathogen genome-wide-association-study\, we identify pathogen gen
 etic factors that contribute to the elaboration of shigellosis. Thus\, who
 le genome sequence analysis of this representative dataset has provided a 
 new lens through which to view the diversity of these pathogens in those p
 opulations most vulnerable to severe disease and highlighted several signi
 ficant hurdles we may face in continued management of the disease through 
 antimicrobials and in implementing future vaccination programs\nSpeakers:\
 nDr Kate Baker (University of Liverpool)
LOCATION:Via Zoom
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/2cbcccab-9d99-4d19-b29f-f10a456f3f82/
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DESCRIPTION:Talk:Informing shigellosis control and management in resource 
 poor settings through pathogen genomics  - Dr Kate Baker (University of Li
 verpool)
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