BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:'Epigenetics meets mathematics: The fusion of experiment and theor
 y brings insights beyond intuition' - Professor Leonie Ringrose (IRI for L
 ifesciences\, Humboldt University\, Berlin)
DTSTART;VALUE=DATE-TIME:20191205T103000Z
DTEND;VALUE=DATE-TIME:20191205T113000Z
UID:https://talks.ox.ac.uk/talks/id/3f5eff2c-0e72-4fd1-a639-6350d37845e7/
DESCRIPTION:Epigenetic gene regulation is highly stable: epigenetic memory
  of gene expression states can persist over many cell generations and pote
 ntially for longer. However\, epigenetic regulation is also flexible: gene
 s that are subject to epigenetic regulation can respond dynamically to env
 ironmental and developmental signals. How can epigenetic regulation be bot
 h stable and flexible? I propose that the key lies in the highly dynamic n
 ature of epigenetic systems. Over the last two decades it has become clear
  that the nucleus is an extraordinarily busy and noisy place: many protein
 s\, including epigenetic regulators\, are in constant motion\, exchanging 
 rapidly between chromatin bound and free states. Quantitative aspects of t
 his motion are highly regulated. I propose that that to fully understand t
 his regulation\, epigenetics needs mathematics. We need ‘‘moving model
 s’’ built of mathematical descriptions\, which we can feed with measur
 ed values of quantities and mobilities of the components. A good model mak
 es testable predictions that tell us whether our hypothesis makes sense. I
 f it does not\, we change the model. There has never been a better time to
  combine theoretical approaches with quantitative experiments. On the theo
 retical side\, the last decade has seen a quiet revolution in the applicat
 ion of models built by physicists to the deep questions of epigenetics. On
  the experimental side\, the advent of technologies that allow real time a
 nalysis at the single cell and single molecule level\, together with those
  that enable targeted genome editing\, allow precise perturbation and quan
 titative measurements at an unprecedented level. It is time for epigenetic
 s to meet mathematics. I will give examples from work in the field and in 
 my own lab\, of how the fusion of experiment and theory has brought fresh 
 insights into epigenetic regulation that go beyond intuition. \nSpeakers:\
 nProfessor Leonie Ringrose (IRI for Lifesciences\, Humboldt University\, B
 erlin)
LOCATION:Dorothy Crowfoot Hodgkin Building (Main Seminar Room)\, off South
  Parks Road OX1 3QU
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/3f5eff2c-0e72-4fd1-a639-6350d37845e7/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:'Epigenetics meets mathematics: The fusion of experiment 
 and theory brings insights beyond intuition' - Professor Leonie Ringrose (
 IRI for Lifesciences\, Humboldt University\, Berlin)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR