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SUMMARY:Investigating the impact of genetic variation on the hypothalamic
 –pituitary–gonadal axis - Hannah (Currant)
DTSTART;VALUE=DATE-TIME:20251125T093000Z
DTEND;VALUE=DATE-TIME:20251125T103000Z
UID:https://talks.ox.ac.uk/talks/id/45dc80d0-2794-48d6-94eb-ea1e08c9d637/
DESCRIPTION:For our next talk\, in the BDI/CHG (gen)omics Seminar series\,
  we will be hearing from Hannah Currant\, Wellcome Early Career Fellow\, N
 DWRH\, Big Data Institute. We’re delighted to host Hannah in what promis
 es to be a great talk!\n\nDate: Tuesday 25 November\nTime: 9:30 – 10:30\
 nLocation: BDI/OxPop seminar room 0\n\nTalk title: Investigating the impac
 t of genetic variation on the hypothalamic–pituitary–gonadal axis\n\nA
 bstract: The hypothalamic-pituitary-gonadal (HPG) axis refers to the syste
 m of interaction and coordination between the hypothalamus\, pituitary and
  gonadal glands that are involved in the development and regulation of the
  reproductive system. The axis is involved in temporal variation in reprod
 uctive hormones across reproductive ageing\, and in females\, cyclical var
 iation with the menstrual cycle. Disruptions to the HPG axis can lead to r
 eproductive pathologies including infertility. This talk will cover severa
 l projects that all look to investigate the impact of genetic variation on
  the function of the HPG axis. We conducted a genome-wide association stud
 y of the morphology of the hypothalamus and pituitary gland using MRI-deri
 ved quantitative phenotypes in the UK Biobank. We are investigating the ge
 netics underlying Idiopathic Hypogonadotropic Hypogonadism\, which causes 
 infertility\, in an international cohort meta-analysis. And looking to the
  future we are investigating the variation in ovarian gene expression acro
 ss reproductive ageing. \n\nBiography: Hannah obtained a BSc in Molecular 
 Biology from the University of St Andrews before completing her PhD at the
  University of Cambridge. There she undertook her research at the EMBL Eur
 opean Bioinformatics Institute (EMBL-EBI)\, focusing on the genetics of re
 tinal morphology using image-derived phenotypes. She then received a Marie
  Skłodowska-Curie Actions Postdoctoral Fellowship to work at the Universi
 ty of Copenhagen on the genetics underlying morphology of neuroendocrine r
 egions using MRI-derived phenotypes before moving to the Nuffield Departme
 nt of Population Health at the University of Oxford. Hannah is now establi
 shing her independent research group at the Nuffield Department of Women
 ’s and Reproductive Health as a Wellcome Early Career Fellow. \n——
 ————————————————————————
 ——————————————\nAll members of the University 
 are welcome to join\, please let reception at BDI know you’re here for t
 he seminar and sign-in. We hope you can join us!\n\nWe also now have a mai
 ling list –\nTo be added\, ping genomics_bdi_whg-subscribe@maillist.ox.a
 c.uk (with any message)\, you should get a bounce-back with three options 
 to confirm your subscription. Follow any of those options\, and with a bit
  of luck you should be signed up!\n\nAs a reminder\, the (gen)omics semina
 r series runs every other Tuesday morning and is intended to increase inte
 raction between individuals working in genomics across Oxford. We encourag
 e in-person attendance where possible. There is time for discussion over\,
  tea\, coffee and pastries after the talks.\n\nHybrid Option:\nPlease note
  that these meetings are closed meetings and only open to members of the U
 niversity of Oxford to encourage sharing of new and unpublished data. Plea
 se respect our speakers and do not share the link with anyone outside of t
 he university.\n\nJoin the meeting now \nMeeting ID: 344 622 735 143 7 \nP
 asscode: vJ7i9cf3 \n——————————————————
 —————————————————\nIf you wish to know m
 ore or receive information related to trainings and events at BDI\, please
  subscribe by emailing bdi-announce-subscribe@maillist.ox.ac.uk. You’ll 
 then receive an email from SYMPA and once you reply you’ll be on the lis
 t!\n\n\nSpeakers:\nHannah (Currant)
LOCATION:Big Data Institute (Seminar room 0 )\, Old Road Campus OX3 7LF
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/45dc80d0-2794-48d6-94eb-ea1e08c9d637/
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DESCRIPTION:Talk:Investigating the impact of genetic variation on the hyp
 othalamic–pituitary–gonadal axis - Hannah (Currant)
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