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SUMMARY:Circadian clock regulation of mucosal immunity - Professor David R
 ay (University of Oxford)
DTSTART;VALUE=DATE-TIME:20190121T120000Z
DTEND;VALUE=DATE-TIME:20190121T130000Z
UID:https://talks.ox.ac.uk/talks/id/465a7b79-d56c-4f36-9995-45c73993fd39/
DESCRIPTION:Recent studies reveal that airway epithelial cells are critica
 l pulmonary circadian pacemaker cells\, mediating rhythmic inflammatory re
 sponses. Using mouse models we now identify the rhythmic circadian repress
 or REV-ERB as essential to the mechanism coupling the pulmonary clock t
 o innate immunity.  Dual mutation of REV-ERBα and its paralog REV-ERBβ i
 n bronchial epithelia further augmented inflammatory responses and chemoki
 ne activation\, but also initiated a basal inflammatory state\, revealing 
 a critical homeostatic role for REV-ERB proteins in the suppression of the
  endogenous pro-inflammatory mechanism in un-challenged cells. Thus\, dyna
 mic changes in stability of REV-ERB protein couple the core clock to in
 nate immunity. \n----\nDavid trained in general internal medicine and endo
 crinology in the UK\, and California.  He developed a research interest in
  nuclear receptor function in inflammation\, which was supported by MRC\, 
 and GSK fellowships.  He then identified the importance of the circadian c
 lock machinery in regulating innate immunity\, using lung\, joint and gut 
 models\, and is extending these studies to human cohorts.  He recently mov
 ed to Oxford\, with Wellcome and MRC support\, to work on circadian contro
 l of inflammation in the lung\, and the re-wiring of circadian metabolism 
 by chronic inflammatory processes.\nSpeakers:\nProfessor David Ray (Univer
 sity of Oxford)
LOCATION:Kennedy Institute of Rheumatology (Bernard Sunley Theatre)\, Head
 ington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/465a7b79-d56c-4f36-9995-45c73993fd39/
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DESCRIPTION:Talk:Circadian clock regulation of mucosal immunity - Professo
 r David Ray (University of Oxford)
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