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SUMMARY:Critical roles for ion and water flux in T cell migration and acti
 vation - Prof Victor Tybulewicz (The Francis Crick Institute\, London)
DTSTART;VALUE=DATE-TIME:20251117T120000Z
DTEND;VALUE=DATE-TIME:20251117T130000Z
UID:https://talks.ox.ac.uk/talks/id/573849b4-9117-46bb-99c6-1940f3cdc69d/
DESCRIPTION:We have identified that WNK1 kinase is required for both T cel
 l activation and migration. In kidney epithelial cells\, in response to hy
 perosmolarity\, WNK1 phosphorylates and activates the OXSR1 and STK39 kina
 ses. These phosphorylate the SLC12A-family of ion transporters\, resulting
  in influx of Na+\, K+ and Cl- ions\, and subsequent water entry by osmosi
 s.\n\nUnexpectedly\, we show that TCR stimulation in CD4+ T cells leads to
  WNK1 activation and subsequent WNK1 signalling results in water influx th
 rough Aquaporin 3 (AQP3). This water influx is required for early TCR sign
 alling in and for entry into cell cycle. \n\nFurthermore\, we show that CC
 R7 chemokine receptor signalling leads to activation of WNK1 at the leadin
 g edge of migrating CD4+ T cells\, resulting in ion influx and consequent 
 water entry by osmosis through AQP3. This water entry swells the membrane 
 at the leading edge\, generating space into which actin filaments can poly
 merize\, thereby facilitating forward movement of the cell. Thus\, WNK1-re
 gulated ion and water influx play critical roles in T cell activation and 
 migration. This requirement may extend to many other immune and non-immune
  cell types. \nSpeakers:\nProf Victor Tybulewicz (The Francis Crick Instit
 ute\, London)
LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea
 dington OX3 7FY
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/573849b4-9117-46bb-99c6-1940f3cdc69d/
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DESCRIPTION:Talk:Critical roles for ion and water flux in T cell migration
  and activation - Prof Victor Tybulewicz (The Francis Crick Institute\, Lo
 ndon)
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