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SUMMARY:Modulating polyamines and polyamine transport in Parkinson’s dis
 ease  - Professor Peter Vangheluwe (KU Leuven\, Belgium)
DTSTART;VALUE=DATE-TIME:20251028T120000Z
DTEND;VALUE=DATE-TIME:20251028T130000Z
UID:https://talks.ox.ac.uk/talks/id/5858edd1-e9ac-4f1a-a0cb-37e4eacbf103/
DESCRIPTION:Parkinson’s disease is one of the most frequent neurodegener
 ative diseases. While the root cause and molecular mechanisms underlying P
 arkinson’s disease remain incompletely understood\, lysosomes are critic
 ally disturbed\, which contributes to the accumulation of misfolded protei
 ns and defective mitochondria. Our lab is specialized in the study of endo
 -/lysosomal polyamine transporters\, such as ATP13A2\, which has been gene
 tically linked with Parkinson’s disease (PARK9 locus). Our research reve
 aled that ATP13A2 transports polyamines out of the lysosome\, contributing
  to lysosomal and mitochondrial health. The M.J. Fox Foundation has priori
 tized ATP13A2 as a new target for Parkinson’s disease\, and our molecula
 r insights into the regulation of ATP13A2 have offered new therapeutic str
 ategies\, which we actively pursue. Our work in the Aligning Science Acros
 s Parkinson’s program demonstrated that a disturbed polyamine homeostasi
 s affects Parkinson’s disease symptoms and that polyamines modulate Park
 inson’s disease pathways. Using preclinical mouse models we evaluate the
  potential of polyamine modulation strategies to rescue the consequences o
 f ATP13A2 deficiency\, and are assembling a patient cohort with ATP13A2 ca
 rriers. Finally\, we study the interconnections between ATP13A2 and closel
 y related polyamine transporters ATP13A3 and ATP13A4\, which remain virtua
 lly unexplored but are emerging as new drug targets. \n\nSpeakers:\nProfes
 sor Peter Vangheluwe (KU Leuven\, Belgium)
LOCATION:Dorothy Hodgkin (This seminar will be held in the Dorothy Crowfoo
 t Hodgkin Building\, Ground Floor Seminar Room (20-138).  Email: opdc.adm
 inistrator@dpag.ox.ac.uk for more details.)
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/5858edd1-e9ac-4f1a-a0cb-37e4eacbf103/
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DESCRIPTION:Talk:Modulating polyamines and polyamine transport in Parkinso
 n’s disease  - Professor Peter Vangheluwe (KU Leuven\, Belgium)
TRIGGER:-PT1H
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