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SUMMARY:Biophysics Seminar 4 TT7 - Professor Eleanor Stride (Institute of 
 Biomedical Engineering\, University of Oxford)\, Peter-Rory Hall (Universi
 ty of Oxford)
DTSTART;VALUE=DATE-TIME:20240607T100000
DTEND;VALUE=DATE-TIME:20240607T110000
UID:https://talks.ox.ac.uk/talks/id/5e21bdea-982f-4555-8b6a-60503cf0e08e/
DESCRIPTION:Talk 1: Engineering Bubbles\nProf Eleanor Stride\, Dept of Eng
 ineering & NDORMS (Oxford)\n\nDespite extraordinary advances in the develo
 pment of new drugs and biotechnology\, the rates of mortality due to cance
 r and cardiovascular disease continue to rise. In many cases the problem l
 ies not with the drugs but rather the difficulty in successfully deliverin
 g them to the target site. The goal of the research being carried out in t
 he Biomaterials and Bioengineering group is to develop new methods for del
 ivering drugs that overcome these barriers. In particular physical stimuli
  such as ultrasound and magnetic fields are being used to localise the rel
 ease and improve the distribution of drugs within tissue using micro and n
 anoscopic bubbles as delivery vehicles. This talk will present the new tec
 hniques that have been developed used to fabricate and characterise these 
 bubbles\; and how they are being translated into the clinic.\n\nTalk 2: Cr
 yoEM Structures and Implications for Gating of TASK K2P K+ Channels\nPeter
 -Rory Hall\, Tucker Group\, Biophysics & Kavli Institute for Nanoscience D
 iscovery (Oxford)\n\nTASK-1 and TASK-3 are pH-sensitive Two-Pore Domain (K
 2P/KCNK) K+ channels. Mutations in the channels are associated with neurod
 evelopmental channelopathies and hypertensive disorders and are targets fo
 r the treatment of disorders including sleep apnea\, pain\, and atrial fib
 rillation. The structural basis for gating in TASK-3 channels and the mech
 anism by which TASK channels sense pH to regulate gating are not fully cle
 ar. To understand this\, we have resolved a range of TASK cryo-EM structur
 es for both TASK-1 and TASK-3\, as well as for common disease-causing vari
 ants. Combined with functional studies\, these structures not only demonst
 rate the mechanism of gating but also provide important insights into the 
 structural changes that occur within the pH-sensing mechanism during chann
 el inhibition.\nSpeakers:\nProfessor Eleanor Stride (Institute of Biomedic
 al Engineering\, University of Oxford)\, Peter-Rory Hall (University of Ox
 ford)
LOCATION:Dorothy Crowfoot Hodgkin Building (DCHB Seminar Room 20-138)\, of
 f South Parks Road OX1 3QU
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/5e21bdea-982f-4555-8b6a-60503cf0e08e/
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DESCRIPTION:Talk:Biophysics Seminar 4 TT7 - Professor Eleanor Stride (Inst
 itute of Biomedical Engineering\, University of Oxford)\, Peter-Rory Hall 
 (University of Oxford)
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