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SUMMARY:Deciphering SP8 regulative network for cortical development - Ugo 
 Borello (University of Lyon)
DTSTART;VALUE=DATE-TIME:20180316T160000Z
DTEND;VALUE=DATE-TIME:20180316T170000Z
UID:https://talks.ox.ac.uk/talks/id/70486aee-98f4-4afd-a72e-6dd7282cfb2f/
DESCRIPTION:The transcriptional network regulating forebrain development r
 emains relatively unknown. Molecules secreted by the different forebrain s
 ignaling centers establish the expression gradients of specific transcript
 ional factors\, which are necessary for the patterning and differentiation
  of the distinct structural and functional domains of the cerebral cortex.
  \nTo get new insights into the transcriptional regulation of forebrain de
 velopment we focused on the role of SP8\, a zinc finger transcription fact
 or involved in early patterning and arealization of the cortex. \nGenome w
 ide analysis of the SP8 binding sites and genetic manipulation of SP8 expr
 ession in the developing pallium allowed us to identify for the first time
  SP8 direct target genes\, and to determine a novel role for SP8 as a key 
 transcriptional regulator of the first wave of cortical neurons differenti
 ation.\n\nSpeakers:\nUgo Borello (University of Lyon)
LOCATION:Le Gros Clark Building (Large Lecture Theatre)\, off South Parks 
 Road OX1 3QX
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/70486aee-98f4-4afd-a72e-6dd7282cfb2f/
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DESCRIPTION:Talk:Deciphering SP8 regulative network for cortical developme
 nt - Ugo Borello (University of Lyon)
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