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SUMMARY:Emergent spatial patterning in engineered bacteria - Dr Neil Dalch
 au (Microsoft Research Cambridge)
DTSTART;VALUE=DATE-TIME:20191115T140000Z
DTEND;VALUE=DATE-TIME:20191115T150000Z
UID:https://talks.ox.ac.uk/talks/id/71f49466-277f-429a-9725-9119dbcb396c/
DESCRIPTION:The spatial coordination of cellular differentiation enables f
 unctional organogenesis. How coordination results in specific patterns of 
 differentiation in a robust manner is a fundamental question for all devel
 opmental systems in biology. Theoreticians such as Turing and Wolpert have
  proposed the importance of specific mechanisms that enable certain types 
 of patterns to emerge\, but these mechanisms are often difficult to identi
 fy in natural systems. Therefore\, we have started using synthetic biology
  to ask whether specific mechanisms of pattern formation can be engineered
  into a simple cellular background. In this talk\, I will show several exa
 mples of emergent spatial patterning that results from the insertion of sy
 nthetic signalling pathways and transcriptional logic into E. coli. In all
  cases\, we use computational modelling to initially design circuits with 
 a desired outcome\, and improve the selection of biological components (DN
 A sub-sequences) that achieve this outcome according to a quantifiable mea
 sure. In the specific case of Turing patterns\, we have yet to produce a f
 unctional system in vivo\, but I will describe new analytical tools that a
 re helping to guide the design of synthetic circuits that can produce a Tu
 ring instability.\nSpeakers:\nDr Neil Dalchau (Microsoft Research Cambridg
 e)
LOCATION:Mathematical Institute (L3)\, Woodstock Road OX2 6GG
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/71f49466-277f-429a-9725-9119dbcb396c/
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DESCRIPTION:Talk:Emergent spatial patterning in engineered bacteria - Dr N
 eil Dalchau (Microsoft Research Cambridge)
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