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SUMMARY:Excitation-inhibition balance in psychosis - what does it really m
 ean\, and can we really measure it?  - Dr Rick Adams (University College L
 ondon)
DTSTART;VALUE=DATE-TIME:20260303T093000Z
DTEND;VALUE=DATE-TIME:20260303T103000Z
UID:https://talks.ox.ac.uk/talks/id/7644e3d3-545b-4bea-b80b-6418f28641e0/
DESCRIPTION:Over recent decades\, the theory that there is an imbalance be
 tween excitation and inhibition in cortical circuits in people with psycho
 sis has become increasingly popular. The exact nature of this imbalance is
  still unclear\, however. One issue is that it is conceptually ill-defined
 . Another reason is that it is hard to measure in vivo. We have found\, us
 ing rodent recordings of simultaneous LFP and cell spiking data\, that mos
 t 'traditional' measures of E/I imbalance (e.g.m\, gamma power\, 1/f power
  spectrum slope\, etc) are not reliable. WE have sued computational modell
 ing of Me/EEG and (fMRI) data to show that there is hypo function of excit
 atory neurone in both established schizophrenia and in the prodromal perio
 d (NAPLS2 dataset)\, although this pathology may not be present in all sub
 groups of psychosis (analysing 'biotypes' from the BSNIP consortium datase
 t). Symptoms such as hallucinations\, however\, seem to relate to disinhib
 ition (the opposite effect). I discuss why this might be\, and what this m
 ight mean for treatments. \n\nThis seminar is hosted in person\, to join o
 nline\, please use the Zoom details below: \n\nhttps://zoom.us/j/933118124
 05?pwd=9kbjSbEcO2fa7n7gFLZVqrChvr467B.1\n\nMeeting ID: 933 1181 2405\nPass
 code: 169396\nSpeakers:\nDr Rick Adams (University College London)
LOCATION:Seminar Room 
TZID:Europe/London
URL:https://talks.ox.ac.uk/talks/id/7644e3d3-545b-4bea-b80b-6418f28641e0/
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DESCRIPTION:Talk:Excitation-inhibition balance in psychosis - what does it
  really mean\, and can we really measure it?  - Dr Rick Adams (University 
 College London)
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